他汀类药物对经皮冠状动脉介入治疗患者术后短期肾功能及炎性指标的影响

摘要

Objective To study the effect of four kinds of statins on short-term renal function and inflammation in patients after percutaneous coronary intervention(PCI).Methods One hundred patients after PCI were selected as research subjects.Patients were randomly divided into experimental group 1,experimental group 2,experimental group 3, experimental group 4,each group had 25 cases.The subjects of experimental group 1 were treated with pravastatin treat-ment,the subjects of experimental group 2 treated with lovastatin treatment,the experimental group 3 treated with simv-astatin,the experimental group 4 treated with atorvastatin.The renal function and inflammation were compared among 4 groups.Results After treatment,the indicators of the experimental group 4 were better than the other three groups, there was statistically significant difference(P<0.05).The four experimental groups were no obvious differences in the inflammatory parameters(sICAM-1,hs-CRP,CRP and Fg)(P>0.05).After treatment,the renal function of patients who received atorvastatin were better than other experimental groups.Conclusion The effect of atorvastatin on renal function and other indexes is positive after PCI.%目的 研究四类他汀类药物对经皮冠状动脉介入治疗(PCI)患者术后短期肾功能及炎性指标的影响.方法 选取接受PCI治疗的100例患者作为研究对象.按照随机数字表法分为试验组1,试验组2,试验组3,试验组4,每组各25例.试验组1:患者接受普伐他汀治疗.试验组2:患者接受洛伐他汀治疗.试验组3:患者接受辛伐他汀治疗.试验组4:患者接受阿托伐他汀治疗,对比各组药物对治疗后的肾功能及炎性指标的影响.结果 用药后,试验组4的血总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇都要优于其他三组,差异均有统计学意义(均P<0.05).四个试验组可溶性细胞黏附因子-1(sICAM-1)以及超敏C反应蛋白、C反应蛋白等各项炎性指标研究发现,差异无统计学意义(P>0.05).对比四个试验组治疗之后尿液肾功能指标发现,试验组4接受阿托伐他汀治疗的患者总体情况好于其他试验组.结论 在PCI术后,阿托伐他汀对患者术后的肾功能等指标的影响具有积极作用.