一种简便的预期最大Lod Score值的推算方法

摘要

提出一种较为简单的单基因遗传病家系预期最大Lod Score的推算方法 。其原理 类似于单倍型分析。可以帮助研究者在正式genotyping之前，对家系的信息含量作一评估。 与Linkage Program Version 5.2中的SLINK相比虽然不够全面,但是有比较简单快捷的优点 。%A simple method is introduced to evaluate the Expected Maximum Lod S core of a certain monogenic pedigree. It can help researchers to calculate the Infor mativemess of a pedigree before genotyping. Comparing with the standard method S LINK in Linkage pregram version 5.2. It is not so comprehesive， but it is simpl er and easier to manipulate.