肝癌干细胞与肝癌的研究进展

摘要

肿瘤起源于干细胞的假说已在人类许多实体瘤中得到证实,近来亦发现肝癌中存在肝癌干细胞.肿瘤干细胞被认为是肿瘤产生的根源,对肿瘤的发生、发展、转移、复发及耐药具有关键作用.因此,如何分离鉴定肝癌干细胞对于改善预防方法、促进早期检测以及研发新的治疗方法都是一个非常紧迫的课题.本文就肝癌干细胞的来源、表面标志、分选方法、应用前景及存在的问题作一综述.%The hypothesis that tumors come from stem cells has been validated in many solid tumors, including hepatocellular carcinoma. Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, development, metastasis, recurrence and resistance of drugs. Therefore, isolation and identification of liver cancer stem cells (LCSCs) are imperative for improving prevention approaches, enhancing early detection and extending the limited treatment options. This review focused on the source, surface markers, isolation and application of LCSCs and the problems that might arise.