6-萘氧甲基-1,3二氧戊环并4,5-g 喹啉-7-甲酸衍生物的合成

摘要

A novel synthesis of naphthalene-containing quinolines,namely,2-(naphthoxymeth-yl)quinoline-3-carboxylic acids has been achieved in one-pot procedure in good yields through Williamson ether synthesis reaction of ethyl 6-(chloromethyl)-[1,3]dioxolo[4,5-g ]quinoline-7-carboxylate with 1-and 2-naphthols followed by ethyl ester hydrolysis reaction.The new syn-thesized compounds would be good candidates for the development of compounds for use in me-dicinal chemistry.%介绍了通过6-氯甲基-[1,3]二氧戊环并[4,5-g ]喹啉-7-甲酸乙酯与1-和2-萘酚的 Williamson 醚合成反应及其随后的酯水解反应,“一锅法”高收率的合成了结构新颖的含有萘环结构的喹啉化合物,即2-(萘氧甲基)喹啉-3-羧酸。这种新合成的化合物可以为开发有用的药物活性先导化合物提供很好的底物。