Receptor-interacting protein(RIP)kinases are a group of threonine/serine protein kinases with a relatively conserved kinase domain but distinct non-kinase regions.A number of different domain structures,such as death and caspase activation and recruitment domain(CARD)domains,were found in different RIP family members,and these domains should be keys in determining the specific function of each RIP kinase.It is known that RIP kinases participate in different biological processes,including those in innate immunity,but their downstream substrates are largely unknown.This review will give an overview of the structures and functions of RIP family members,and an update of recent progress in RIP kinase research.
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机译:Structure Determination and Mechanistic Insights of: I.Cyanobacteriochrome NpR6012g4 Light Sensor Protein in Phototaxis II.Retinal Degeneration 3 (RD3) Protein in Vision III.Ryanodine Receptor 2 (RyR2) Regulation by Calmodulin (CaM) in Cardiac Function =结构测定和机理洞悉:I.趋光性中的蓝细菌色素NpR6012g4光敏蛋白 II.视觉作用中的视网膜退化蛋白3 III.心脏功能中的钙调蛋白调控兰诺定受体2