儿童支原体肺炎血清总补体活性(CH50)和补体C3变化的临床意义

摘要

Objective :To explore the serum concentration changes of total complement activity(CH50) and C3 in children with mycoplasmal pneumonia (MP). Methods: Liposome immunoassay was used to determine the serum concentration of CH50 C4and C3 in 62 children with bronchopneumonia, together with determination of anti-MP-IgM (serum) by the SERODIA-MYCOⅡ passive agglutination assay in ali patients. The total 62 children were divided into mycoplasma pneumoniae pneumonia ( MPP;n = 30) and non- mycoplasma pneumoniae pneumonia (NMPP) group( n =32) based on the results of anti-MP-IgM. Results: In MPP group, the serum concentration of CH50 and C3 ( 11.63 - 8.01,1.04 ± 0.18 ) was significantly lower than that of the NMPP group( 18.23 ± 8.49, 1.30±0.35 ), which was different in statistics( P ＜0.05 ), and yet, no difference was found between the two groups concerning serum complement C4 (0.31 ± 0. 13 vs. 0. 32 ± 0. 07; P ＞ 0. 05 ). Conclusion: The results of serum CH50 and C3 determination is valuable in clinc to the diagnosis and treatment of children with mycoplasmal pneumonia.%目的:探讨儿童支原体肺炎血清总补体活性(CH50)和补体C3变化.方法:采用脂质体免疫法测定62例支气管肺炎患儿血清CH50、C3和C4浓度;同时采用SERODIA-MYCOⅡ明胶颗粒法测定所有患儿血清抗MP-IgM,根据抗MP-IgM结果分为肺炎支原体肺炎组(30例)和非肺炎支原体肺炎组(32例).结果:MPP组血清CH50、补体C3(11.63±8.01、1.04±0.18)均明显低于非MPP组(18.23±8.49、1.30±0.35),两组差异有统计学意义(P< 0.05);MPP组血清补体C4(0.31±0.13)与非MPP组(0.32±0.07)比较,两组差异无统计学意义(P＞0.05).结论:测定血清CH50、C3对儿童支原体肺炎诊断和治疗有一定的临床意义.