Process intensification in biomanufacturing driven by advances in single use technologies

摘要

1. Process intensification can be implemented in most processes but should be evaluated already during development 2. In USP the highest efficiency gain by improving the seed/inoculation train and a step elimination strategy 3. Process intensification in DSP allows more options (resins, membranes, procedures, etc.) 4. The biggest benefit in DSP by combining operations (precipitation, mixed mode resins, SPIFF and chromatography) 5. Disposables have a huge impact on intensification by eliminating labor and preparation time 6. Continuous processing is easiest established in the USP but new DSP approaches support end to end continuous processes 7. Personalized medicine can significantly benefit from integrated intensified processes based on disposable elements.