Ethanol Mangosteen Rind Extract (Garcinia x-mangostana L.) Activity on Wistar White Male Rats Ureum Creatinine Levels

摘要

Objectives: Kidney is organ that plays an important role in maintaining the homeostasis of the body. Kidney damage can be caused by several things, such as hypovolemia, sepsis, acute glomerulonephritis, rhabdomyolysis and drugs (gentamicin and NSAIDs). Consumption of drugs like gentamicin can cause damage and decreased kidney function through the formation of free radicals. Mangosteen rind could be expected to provide nefroprotector based antioxidant effect. These research was to determine the activity and effective doses of mangosteen rind (Garcinia x-mangostana L.) ethanol extract on gentamicin induced male rat creatinine and Blood Urea Nitrogen (BUN) level. Rats were divided into 5 groups. Group I as normal control (Aquadest po), the second group of negative control (Gentamicin 60 mg/kgBW ip), group III, IV, and V (extract of mangosteen rind dose of 50 mg/kgBW; 100 mg/kgBW; and 200 mg/kgBW orally for 7 days). After dossage administered, followed by induction of gentamicin for 7 days. According to ANOVA with 95% level of confidence, the results showed that mangosteen rind ethanol extract gives a significant differences, which Dose II and Dose III can reduce creatinine levels, as well as protects from necrosis with average levels of creatinine 1,086 mg/dl and 1,158 mg/dl. However, mangosteen rind (Garcinia x-mangostana L.) ethanol extract had no activity on BUN levels.