Moderate Intensity Exercise Eliminates the Inflammation Marker in the Liver of High-Fat-Diet-Induced Obese Mice

摘要

The obese metabolic complication has already occurred nowadays. The purpose of the study was to investigate the effect of moderate intensity exercise on inflammation marker in the liver of high fat-diet-induced-obese mice. The 4 weeks male C57BL/6 mice were randomly dispersed to three groups: normal diet control (NC; n=10), high-fat diet control (HC; n=10), a high fat diet with moderate intensity exercise (HME; n=10) groups. The high fat diet was given 60% calories from fat whereas normal diet was given 18% calories from fat. The moderate intensity exercise group (HME) was set at 10m/min in the first 2 weeks, 12m/min in 3-5 weeks and 14m/min in 6-16 weeks. The inflammation markers were checked by quantitative Real Time PCR. The body and liver weight was significantly increased in the high fat diet group. The moderate intensity exercise significantly reduced the gene expression of TNFα, and IL-1β the pro inflammatory cytokine IL-10 was significantly decreased in the high fat diet group but not with moderate intensity exercise. In conclusion, moderate intensity exercise has a positive effect on the liver of high-fat-diet-induced obese by reducing inflammation gene expressions. However, there was no effect of moderate intensity exercise on TLR4 and Ih-10.