Ursodeoxycholic Acid (Ursodiol) Significantly Alters the Gut Microbiota and Bile Acid Metabolome in Conventional Mice

摘要

Ursodeoxycholic acid (ursodiol) is a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases. Ursodiol has a multitude of beneficial therapeutic effects and can modulate bile acid pools. Bile acids can alter the gut microbiota community structure through various mechanisms. In turn, the gut microbial community can modulate bile acid pools, thus highlighting the interconnectedness of the gut microbiota-bile acid-host axis. Despite these interactions, it remains unclear if and how exogenously administered ursodiol shapes the indigenous gut microbial community structure and intestinal bile acid metabolome. This study aimed to provide a comprehensive analysis of how ursodiol alters the intestinal ecosystemin conventional mice.