MEDICAL, SURGICAL RADIATION ONCOLOGY: PRACTICAL APPROACH TO DIAGNOSIS AND MANAGEMENT OF HISTIOCYTIC SARCOMAS IN DOGS CATS

摘要

Histiocytic proliferative disorders in dogs are a spectrum of disease from reactive to neoplastic.1'2 They can be difficult to differentiate from granulomatous, reactive inflammatory, or lymphoproliferative disorders.3Cutaneous Histiocytoma: -single lesion, young dog (< 3 years), regress,-epidermal Langerhans cells: CD la, CD1 lc, E-cadherin, MHC class II Cutaneous Histiocytosis: -single or multiple lesions wax & wane, limited to skin and subcutis-interstitial dendritic cells: CD la, CD1 lc, MHC class II, Thy-1, CD4 (E-cadherin negative) Systemic Histiocytosis: -skin lesions +/- mucous membrane, lymph node and organ involvement (spleen, liver, lung), 3-9 years old-BMD, golden retrievers, Irish wolfhound-interstitial dendritic cells: CD la, CD1 lc, MHC class II, Thy-1, CD4 Histiocytic Sarcoma: -local or systemic lesions-variable cell origin: dendritic cells CD1, CD1 lc, CD 18, MHC II (E-cadherin negative), hemophagocytic HS histiocytes express CD1 Id instead of CD1 lc.