Development of the IRIS toxicological review of inorganic arsenic

摘要

The U.S. Environmental Protection Agency (U.S. EPA) Integrated Risk Information System (IRIS) Program is developing a state-of-the-science Toxicological Review of Inorganic Arsenic (iAs). The approaches to assess the hazard and dose-response of iAs, and the associated uncertainty, are based on evolving practices in the IRIS Program and are guided by National Research Council (NRC) recommendations. The review is incorporating several new elements, including comprehensive problem formulation and planning involving stakeholders,and explicit quantitative consideration of sensitive sub- population risks and risk modifiers. The review will also integrate thorough analyses of adverse outcome pathways and networks to inform causal determinations and dose-response model choices, categorical and Bayesian regression meta-analyses of studies to examine dose-response, and Bayesian analyses of uncertainties.