Autophagy Inhibition Promotes HDACI-induced Apoptosis in MCF-7 Breast Cancer Cells

摘要

Histone deacetylases (HDACs) are considered to be a class of the most promising targets for anticancer agents. Histone deacetylase inhibitors (HDACIs) promote histone acetylation and subsequent chromatin relaxation and uncoiling, which can facilitate transcription of many cancer-related genes. In our preliminary study, a series of cyclic tetrapeptides were designed and synthesized based on the structures of the natural products Trichostatin A (TSA) and chlamydocin. Among these compounds, compound 2 (Cyclo(-L-Asu(NHOH)-L-A3mc6c-L-Phe-D-Pro-), C-2) showed the greatest potential anticancer activity.