IL6 -174G>C and TNFA -308G>A polymorphisms in Bulgarian patients with COPD and Bronchial asthma.

摘要

COPD and Bronchial asthma are multifactorial chronic lung diseases driven by abnormal inflammatory reactions. Therefore, inflammatory mediators are considered of distinct importance in pathogenesis of these conditions. In the current case-control studies we investigated promoter polymorphisms in the genes of interleukin 6 (IL6 -174G>C) and tumor necrosis factor alpha (TNFA -308G>A), known to affect the transcriptional levels of the encoded cytokines. We genotyped 164 patients with COPD, 47 with Bronchial asthma and 174 control individuals using PCR-RFLP-based methods.