Multiscale Design of a Laser Actuated Micro Bubble Array Acoustic-Fluidic Microdevice for Bioanalytical and Drug Delivery Applications

摘要

Next generation fluidic micro-nano devices will require precise control of force fields within a device and their interaction with a biological sample Current force field designs use mechanical structures such as cantilevers, optical fields (e.g. laser tweezers), or electrokinetic fields (e.g. dielectrophoretic devices). All of them suffer from design complexity, small forces, long actuation times, and others. We propose a novel opto acoustic device for fast generation of 3D spatially distributed large force fields within the micro/nano fluidic device. The basic concept is to dynamically produce a field of oscillating micro/nano bubbles which will generate desired 3D pressure and/or flow fields within the device. This concept can be used for bioanalytical applications in vitro exploration of novel drug formulations, novel drug delivery modalities, e.g. to cells and tissues, and for micro/nano surgical applications, Wang et, al. showed experimentally that a micro bubble induced by laser pulse can generate a net streaming flow (Wang, 2004). Their results provide a basic understanding how the blood clot could be broken, emulsified and removed. It is obvious that the bubble formation, growth and collapse are the keys to understand the bubble dynamics and its interaction with the medium, such as blood clot, biological cells, or bio device.