MALDI-TOFMS of synthetic polymers as advanced high-throughput screening tool in combinatorial polymer chemistry

摘要

Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometry (MALDI-TOFMS) is one of the most important MS techniques currently used for polymer analysis. It is known to be a very useful tool for the characterization of synthetic polymers in terms of absolute molecular weights, molecular weight distributions and endgroup analysis.The most difficult part in MALDI analysis is the sample preparation, which is crucial for the success of the MALDI experiment.