pH-degradable Polymer MRI Contrast Agent and Hydrogel Nanoparticle as Trackable Delivery System

摘要

Medical imaging methods including positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and optical imaging usually involve a contrast agent chelating a metal atom or ion. PET and SPECT agents include radioisotopes such as ~(111) In and Ga, MRI agents often bear Mn~(2+) and Gd~(3+) , and optical agents use lanthanides e.g. Eu, which luminesce. These chelators are generally macrocyclic; those most commonly used include 1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and diethylene triamine pentaacetic acid (DTPA).