Designed Artificial Skins Prepared from Modified Microbial Cellulose Dressings for Wound Healing

摘要

Novel designed artificial skins prepared from modified microbial cellulose dressings for wound healing could be established. Microbial cellulose (MC) synthesized in abundance by Acetobacter xylinum showed potential as novel wound healing systems. The modification of microbial cellulose (MC) could be carried out by dipping in alginate solution. The high mechanical strength and remarkable physical properties would be obtained. This study attempts to focus on developments and applications of microbial cellulose (MC) in the emerging field of novel wound dressings and skin substitutes. It considers the properties of the synthesized material as well as progress in the commercialization of MC for wound care products. Efficient and inexpensive fermentation techniques, not presently available, will be necessary to produce large quantities of the polymer. In this study, all wound dressings having various CaCl2/alginate complex layers shows an increase of water uptake with increasing time. Comparing with wound dressing containing various CaCl2/alginate complex layers, initial water uptake reached 230% and 150% after six hours for 0.05M CaCl_(2(aq.))/alginate complex and 0.2M CaCl_(2(aq.))/alginate complex, respectively. After 300 hrs, water uptakes of wound dressing having mixed CaCl_(2(aq.))/alginate complex were observed in the values of 475% and 300% for 0.05M CaCl_(2(aq.))/alginate complex and 0.2M CaCl_(2(aq.))/alginate complex, respectively. New wound healing systems of MC with CaCl_(2(aq.))/alginate complex could be designed as a good choice for wound care management.