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EFFECT OF HYDROCOLLOIDS ON LOWERING BLOOD GLUCOSE

机译:水胶体对降低血糖的影响

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There is growing interest in lowering the post-prandial blood glucose response (PPG) to carbohydrate-rich meals, to help reduce risks of chronic cardiometabolic diseases. Starch digestibility is mainly determined by the intrinsic starch characteristics such as amylose/amylopectin ratio and the botanical source. Processing factors such as cooking, baking and cooling also determine the glycaemic effects. Much effort has been dedicated to transforming rapidly digestible starch (RDS) into slowly digestible starch (SDS) by changing the properties of the starch, but this is complicated by the simultaneous formation of resistant starch (RS), which in large amounts can lead to gastrointestinal complaints. Hydrocolloids contain colloid particles, either digestible such as starch or indigestible such as gums (viscous/gelling fibres), dispersed in water. SDS content can be increased by adding hydrocolloids which are viscous (such as guar gum) or gel-forming (alginates, pectins) under gastrointestinal conditions, and these can lower PPG. Both the viscosifying and gelling potential of these hydrocolloids are related to their concentration and intrinsic properties e.g., the hydrodynamic properties, molecular weight, and solubility. In addition, the hydrodynamic properties of the gums depend on the solvent nature and environment i.e. food matrix and composition of gastrointestinal fluid and mechanical forces exerted by the body. Lastly, in vitro methods are an inexpensive tool to evaluate the properties of hydrocolloids under gastrointestinal conditions, to screen and prioritize hydrocolloid-containing materials for clinical testing of their PPG-lowering efficacy, and clarify their mechanism of action, which can be used to further optimise effects.
机译:对富含碳水化合物的膳食进行降低粉碎后血糖反应(PPG),越来越感兴趣,以帮助降低慢性心肌截障症的风险。淀粉消化率主要由诸如直链淀粉/淀粉素比和植物源的固有淀粉特性确定。烹饪,烘焙和冷却等处理因素也决定了血糖作用。通过改变淀粉的性质,努力将快速消化的淀粉(RDS)转化为缓慢消化的淀粉(SDS),但通过同时形成抗性淀粉(RS),这在大量可能导致的情况下复杂胃肠投诉。水致胶体含有胶体颗粒,可消化,例如淀粉或难以消化的颗粒(粘性/胶凝纤维),分散在水中。通过在胃肠环境下添加粘性(例如瓜尔胶)或凝胶形成(藻酸盐,果胶)的水胶体可以增加SDS含量,并且这些可以降低PPG。这些水胶体的粘度和胶凝潜力均与其浓度和内在性质有关,例如,流体动力学性质,分子量和溶解度。此外,牙龈的流体动力学性质取决于溶剂性质和环境,即食物基质和胃肠流体的组成和由身体施加的机械力。最后,体外方法是一种廉价的工具,用于评估胃肠环境下水胶体的性质,以筛选和优先考虑含氢胶体的材料,以临床测试它们的PPG降低功效,并阐明它们的作用机制,可用于进一步优化效果。

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