OBSERVATIONS ON PRAZIQUANTEL CONCENTRATIONS DURING EXPERIMENTAL AND CLINICAL USE IN MARINE AQUARIA

摘要

Praziquantel baths are a routine part of marine fish quarantine; however, data to support doses, dosing intervals, or stability of the drug in marine systems are lacking. Over the past 2 yr, New England Aquarium has conducted several modest experiments to assess praziquantel potency, stability, limit of detection, and concentrations during clinical use. In addition, the effects of ozone and activated carbon on praziquantel concentrations were investigated. Results suggest that the residence of time of praziquantel in marine systems is very variable, from less than 24 hr in some systems, to over a week in other systems, even during active attempts to remove it faster.