Determination of Low Concentration of Oxymorphone and 6(beta)-hydroxyoxymorphonein Human Plasma by LC-MS/MS

机译：通过LC-MS / MS测定低浓度的氧解氧基酮和6（β-羟基氧毒氧中的人血浆

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

A sensitive LC-MS/MS method has been developed and validated for the measurement of oxymorphone and 6beta-hydroxyoxymorphone in human plasma over the range of 10 - 3000 pg/mL. The assay was successfully applied to support a bioequivalence study. The incurred sample reproducibility assessment showed that 100percent and 98.7percent of the samples evaluated met the pre-specified acceptance criteria for oxymorphone and 6beta-hydroxyoxymorphone, respectively.

机译：已经开发并验证了敏感的LC-MS / MS方法，用于测量人血浆中的氧解酮和6β-羟基氧基酮，在10-3000pg / ml的范围内。成功应用测定以支持生物等效性研究。所产生的样品可重复性评估表明，样品的100％和98.7分别评估了甲状腺白酮和6β-羟基氧基酮的预先指定的验收标准。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2009年||共1页
会议地点
作者
Hongkun Liang; Crystal Nguyen; Hongzhuan Chen; Mojdeh Vahid; Kristen Singleton; Jared Callan; Yongdong Zhu; Yuan-Shek Chen; Kumar Ramu;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K(2)EDTA plasma [J] . Soni Krunal, Bhatt Chandrakant, Singh Kanchan, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2017,第2期

机译：用于定量测定2-吡啶乙酸的LC-MS / MS测定，使用低体积人K（2）EDTA等离子体的β-吡啶乙酸的定量测定，主要代谢物和孕级替代品。
2. A Simple and Sensitive LC-MS/MS Method for the Simultaneous Determination of Cyclophosphamide and Dexorubicin Concentrations in Human Plasma [J] . He Wenxuan, Martin Jennifer H., Shaw Paul N., Current pharmaceutical analysis. . 2018,第1期

机译：一种简单敏感的LC-MS / MS / MS方法，用于同时测定人血浆中环磷酰胺和甲霉素浓度
3. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma [J] . Ding Xiao, Chen Yuan, Sahasranaman Srikumar, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2016,第12期

机译：支持的液体萃取LC-MS / MS方法测定人血浆中小分子Checkpoint激酶1抑制剂GDC-0425的浓度
4. Determination of Low Concentration of Oxymorphone and 6(beta)-hydroxyoxymorphonein Human Plasma by LC-MS/MS [C] . Hongkun Liang, Crystal Nguyen, Hongzhuan Chen, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：通过LC-MS / MS测定低浓度的氧解氧基酮和6（β-羟基氧毒氧中的人血浆
5. Determination of the Levels and Concentrations of the Most Used Autism Spectrum Disorder Medications (Olanzapine, Risperidone and Quetiapine) in Autistic Patient’s Plasma by Using Lc/Ms/Ms [D] . Fraih, Dana Fayez. 2020

机译：通过使用LC / MS / MS测定自闭症患者血浆中最常用的自闭症谱系药物（Olanzapine，Risperidone和Quetiapine）的水平和浓度
6. Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency [O] . Jakub Krijt, Jana Kopecká, Aleš Hnízda, -1

机译：LC-MS / MS测定人血浆中胱硫醚β-合酶活性：可用于诊断CBS缺乏症
7. Validation of an LC-MS/MS Method for the Determination of Propofol, Midazolam, and Carbamazepine in Rat Plasma: Application to Monitor Their Concentrations Following Co-administration [O] . El Hamd Mohamed Abo, Wada Mitsuhiro, Ikeda Rie, 2015

机译：验证LC-ms / ms法测定大鼠血浆中丙泊酚，咪达唑仑和卡马西平的含量：应用于共同给药后监测其浓度

Determination of Low Concentration of Oxymorphone and 6(beta)-hydroxyoxymorphonein Human Plasma by LC-MS/MS

摘要

著录项

相似文献

相关主题

期刊订阅