PATHOGENESIS OF DIC: A ROCKY ROAD

摘要

Dissemination intravascular coagulation (DIC) was first described in human medicine in a lecture by W.H. Seegers to the Cincinnati Academy of Medicine on April 18, 1950. DIC is also been referred to as consumptive coagulopathy, defibrination syndrome,or diffused intravascular clotting. Disseminated intravascular coagulation (DIC) is a disorder characterized by massive systemic intravascular activation of coagulation, leading to widespread deposition of fibrin in the circulation which can compromisethe blood supply to various organs, thus contributing to multiple organ failure. At the same time, the consumption of platelets and coagulation proteins resulting from the ongoing coagulation may induce severe bleeding. However, DIC is not a disease itself but is always secondary to an underlying disorder. In fact, a variety of clinical conditions may cause systemic activation of coagulation. Table 1 lists the diseases most frequently associated with DIC in dogs and cats. Bacterial infections, in particular septicemia, are the most common clinical conditions associated with DIC.