Tauroursodeoxycholic acid antagonizes taurolithocholic acid-induced cholestasis via a cooperative protein kinase C- and protein kinase A-dependent signalling pathway in the perfused rat liver

摘要

Ursodeoxycholic acid (UDCA) has been known for two decades for its anticholestatic effect both, in models of experimental cholestasis1 and human cholestatic liver disease2'3. The exact molecular mechanisms of its anticholestatic action, however, are only partly unravelled4.