Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) Improves Spectral Quality while Retaining Quantitation Accuracy in Isobaric Tag-based Quantitative Proteomic Studies

摘要

More product ions are recorded for improved spectral interpretation using EThcD. XCorr values are significantly increased. Sequence coverage with preservation and localization of labile PTM sites is improved.