Population proteome investigation of Pseudomonas aeruginosa clinical isolates collected from cystic fibrosis patient airways

摘要

Heritable changes within the infecting bacterial population can be revealed through population proteome analyses from cultured cells. Population proteome analysis indicates that lung region-specific evolution results in population diversity within patient lungs. Results revealed increased expression of virulence factors in regions that suffered increased damage. Whole genome sequencing confirmed this heritable change and revealed mutations in a negative regulator (ExsD) of type III secretion.