A simple urinary test: the key to solving the ongoing debate about the indications of aspirin in cardiovascular prevention?

摘要

The role of aspirin in primary prevention has been questioned without taking into account the interindividual variability in the response to oral antiplatelet drugs. AIMS: To assess the factors associated with "aspirin resistance". METHODS: N= 140 with moderate-high CV risk, distributed in two groups: 77.85% (treated group) and 22.15% (aspirin-naive group). Urinary levels of HdhTxB2. RESULTS: In the aspirin-naive group, 38.7% had low 11dhtbx2 levels. In the aspirin-treated group, only 58.3% of patients reached the anti-aggregant target. Higher values of weight, BMI and waist circumference were associated with aspirin resistance. CONCLUSIONS: 1. More than a third of aspirin-naive patients could have a "constitutive platelet antiaggregation". 2. Weight, BMI and waist circumference are related to "aspirin resistance".