PTEN and Tumor

摘要

PTEN was the firstly found cancer suppressor gene with dual-specificity phosphatase (DPS) activities. The gene bas connection with the sporadic tumors and hereditary diseases characterized by tumor-like growth in humans. PTEN can specifically dephosphorylate the phosphatidyIinositol-3, 4, 5-triphosphoric acid [PIP3], and antagonize PI3K-AKT signaling pathway to be at work, and hence regulates the growth, multiplication, migration and apoptosis of cells. PTEN mutations are mainly reflected in genie mutation and heterozygous losses, which is involved in the occurrance, development and prognosis of multiple tumors.