Using MicroRNA-122 Mimics or MicroRNA-451 Inhibitors to Prevent the Osteoarthritis Process

摘要

Rat articular chondrocytes produce endogenous miR-122. MiR-122 exhibits a marked ability to prevent the IL-1β dependent increase in pro-inflammatory and catabolic molecules. MiR-451 exacerbates the inflammatory response in the presence of IL-1β in this model. These microRNA may modulate the uncontrolled inflammatory response present in OA by treatment with miR-122 mimic, or miR-451 inhibitor in osteoarthritic knees.