首页> 外文会议>Frontiers in Biomedical Devices Conference; 20070607-08; Irvine,CA(US) >A MICRO/MINI CHANNEL BASED CONCENTRATOR OF E. COLI IN WATER FLOW
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A MICRO/MINI CHANNEL BASED CONCENTRATOR OF E. COLI IN WATER FLOW

机译:基于微/最小通道的大肠杆菌在水流中的浓缩

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摘要

The objective of this research is to design and optimize a mini/micro-channel based concentrator of E. coli and integrate it with an acoustic wave biosensor. A computational research has been carried out using the state of the art computational software. CFD-ACE with water as bacteria bearing fluid. E. coli bacteria have been modeled as random discrete particles tracked by solving the Lagrangian equations. The design challenges are to achieve high particle to water ratio, high enough Reynolds number to avoid bacteria swimming, and various particle boundary conditions. The optimized design has achieved concentration of about an order of magnitude higher than the inlet concentration at a flow velocity much higher than the bacteria swimming speed under various particle-boundary interactions. Bypass channels have been used to separate concentrated water-particle mixture and to put this mixture directly onto the biosensor's bacteria detecting surface for safe and precise installation of the biosensor in the tluidic chip.
机译:这项研究的目的是设计和优化基于微型/微通道的大肠杆菌浓缩器,并将其与声波生物传感器集成。已经使用最新的计算软件进行了计算研究。 CFD-ACE以水作为细菌的积液。大肠杆菌已被建模为通过求解拉格朗日方程式跟踪的随机离散颗粒。设计上的挑战是要实现高的颗粒水比,足够高的雷诺数以避免细菌游动以及各种颗粒边界条件。优化的设计在各种颗粒边界相互作用下,以比细菌游动速度高得多的流速,实现了比入口浓度高约一个数量级的浓度。旁路通道已用于分离浓缩的水颗粒混合物,并将该混合物直接放置在生物传感器的细菌检测表面上,以将生物传感器安全准确地安装在流体芯片中。

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