Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases

摘要

Raman spectroscopy is an optical diagnostic technique applied in this study to characterize breast tissue by biochemical signature spectra. In cross-validated results, Raman spectroscopy identifies invasive breast carcinoma with 75 - 97% agreement with histopathology opinion. Axillary lymph nodes from patients with breast carcinoma were mapped with confocal Raman spectroscopy and col our-weighted principal component analysis (PCA) images were used to identify local biochemical features and correlate these with parallel section slides analysed with routine histology.