NIDDM

摘要： Objective: The association between type 2 diabetes mellitus and certain endocrine disorders has the paucity of information and limited data in the province of Meisan (southern of Iraq). Hence, in the present study, an attempt was made to investigate the levels of plasma HbA1c, serum insulin resistance and levels of serum sex hormones in men and women of control and type 2 diabetic patients. Also, the present study aimed to explored the correlation coefficient (r) between insulin resistance and level of HbA1c, FSH, LH, Tt, progesterone and estradiol in men and women patients with NIDDM. Methods: One hundred Iraqi volunteers with abdominal obesity were selected in the present study. Fifty diabetic patients with NIDDM (26 men, and 24 women) aged between (37) and (65) years and 50 healthy individuals (25 men, and 25 women) aged between (36) and (65) years considered as control group. Complete medical history was taken from each subject and complete clinical examinations were performed for all volunteers. Then, the two groups were matched for their fasting blood sugar, BMI, insulin hormone;c-peptide, HbA1c, sex hormones and insulin resistance parameters (HOMA2-IR, HOMA%B and HOMA%S) were calculated using HOMA2 calculator software. Results: We found that insulin resistance demonstrated negative correlations (p 0.05) with levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, progesterone and estradiol. While, there was a positive and significant correlation (p 0.01) with value of HbA1c in men and women NIDDM patients. Conclusion: We conclude that an increase in the level of insulin resistance is associated with increased level of blood HbA1c and decreased in level of serum sex hormones (FSH, LH, Tt, E2 and progesterone) in men and women of diabetic group. These behaviors might suggest that insulin resistance can be used as a potential biomarker for predicting dysfunction of sex hygiene in NIDDM patients in addition to glycemic control.

摘要： Ⅱ型糖尿病（NIDDM）简要分析来看是种多基因遗传异质性代谢紊乱型疾病，其病因以及发病机制在目前的研究情况下仍存在疑惑。本文从DAG/PKC信号通路方面阐述近年来NIDDM分子调控机理研究进展，这将为研发有效的降糖药物提供技术借鉴。

摘要： 正糖尿病(diabetes mellitus)是由于胰岛素绝对或相对不足引起的以高血糖和多并发症并存为特征的内分泌代谢性常见病、多发病,可分为胰岛素依赖性糖尿病(insulin dependent diabetes,IDDM,又称Ⅰ型糖尿病)及非胰岛素依赖型糖尿病(non-insulin dependent diabetes,NIDDM,又称2型糖尿病),是一种严重危害人体健康的常见慢性终身疾病。随着社会的发展,人口老龄化的趋势,糖尿病已

摘要： Introduction: Lipid and thyroid function abnormalities are common in IDDM and NIDDM. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to patient with diabetes. Aims: To study on lipid profile and thyroid function in IDDM and NIDDM and the effect of glycemic control on it. Patients and Methods: This was a retrospective study carried out in the Dept. of Endocrinology, BIRDEM, Dhaka, Bangladesh during the period of January, 2012 to May, 2012. In this study, population consisted of 120 subjects (Age between 40 - 72 years;and Sex matched) divided into two groups: patient with diabetes 60 subjects (male-30, female-30) and patient without diabetes 60 subjects (male-30, female-30). Plasma glucose, HbA1c and serum lipids were measured by enzymatic method. Thyroid hormones were measured by a Chemiluminescent Micro particle Immunoassay (CMIA).Results: The statistical significance was evaluated by Student’s t-test, Correlation-Coefficient test. All Values are given as mean ± SD. The level of serum TSH in patient with diabetes (3.43 ± 2.71) was significantly (p 0.05) increased compared to patient without diabetes subjects (1.98 ± 1.72). TSH levels were positively correlated with fasting plasma glucose (r = 0.240, p 0.05), serum cholesterol (r = 0.290, p 0.020) and triglyceride concentration (r = 0.246, p 0.05). On the other hand, free T4 levels were inversely correlated with postprandial blood glucose (r =-0.256, p 0.046). Conclusions: It may be concluded that the lipid and thyroid function abnormalities with others socio-demographic and biophysical risk factors were more common in patient with diabetes cases rather than patient without diabetes cases. Therefore, further prospective studies with larger number of patients are required to strengthen the observations of the present study.

摘要： 目的 研究盐酸罗格列酮治疗NIDDM中的增效作用.方法 75例NIDDM患者中在原治疗基础上加服盐酸罗格列酮(文迪雅)2～8mg/d,共12周观察血糖、血脂LDL、HDL各项指标的变化,并将各项指标进行比较.结果 治疗12周后,空腹和餐后2h血糖及糖化血红蛋白均明显降低,三酰甘油明显降低;胆固醇、高密度腊蛋白升高.结论 罗格列酮在降低血糖的同时能改善血脂代谢,对NIDDM及其并发症有良好的防治功能.

摘要： 临床实践证明，对有胰岛素抵抗的NIDDM患者，用胰岛素控制血糖只有暂时和表面现象，并不能纠正机体的代谢紊乱，相反可能会因长期胰岛素积蓄导致代谢紊乱。因此，认为长期外源性胰岛素积蓄所带来的一系列代谢紊乱在糖尿病性视网膜病变中可能起着一定作用。目前，有关NIDDM患者使用胰岛素控制血糖对糖尿病性视网膜病变的影响报道较少，尚需临床进一步探索。

摘要： 目的:探讨三消丹胶囊对非胰岛素依赖型糖尿病(NIDDM)的治疗效果.方法:76例按WHO诊断标准诊断为NIDDM的患者,口服三消丹胶囊,5粒/次、3次/d,4周为1疗程,连续观察3个疗程,检测治疗前后的空腹血糖.结果:显效47例(61.84%),有效19例(25%),无效10例(13%),总有效率86.84%.治疗前后血糖测定结果比较,第1疗程与治疗前无显著性差异(P＞0.05),第2、3疗程与治疗前比较有显著性差异(P＜0.05、P＜0.01).结论:三消丹胶囊组方合理,疗效确切,未见不良反应,值得推广应用.

摘要： 众所周知，高血压与糖尿病都是动脉硬化的危险因素，两者共存则能导致高度危险状态。伴随年龄的增长患高血压和糖尿病的人也随之增多，当然，合并高血压糖尿病的患者也在增加。另一方面，老年高血压、糖尿病患者与其他年龄段患者相比，其病况及治疗原则也存在差异。本文就老年糖尿病患者中的高血压治疗进行阐述。

摘要： 早期Ⅱ型糖尿病（NIDDM）肾病缺乏明显临床表现，诊断比较困难，一旦发生糖尿病肾病则缺乏有效方法控制其发展，成为NIDDM晚期死亡主要原因，早期诊断、及时防治有重要临床意义。

摘要： 为了证实老年冠心病（CHD）合并2型糖尿病（NIDDM）患者体内血栓形成前状态（PIS）的存在，我们通过检测老年CHD合并NIDDM患者血液止凝血分子标记物在两种疾病并存的变化情况，并分析其影响因素，为临床早期诊断和治疗血栓性并发症奠定理论基础．

摘要： 以高血压、糖尿病大鼠作为研究对象,初步探讨针刺、艾灸的作用差异,通过对针刺、艾灸、针加灸对二肾一夹型高血压大鼠肾素—血管紧张素—醛固酮系统的影响以及针刺、艾灸、针加灸对糖尿病大鼠(NIDDM)空腹血糖、血清C肽、血清SOD、(MDA)影响的观察,结果显示针刺、艾灸均可降低高血压大鼠的血压,二者共同使用与单独针刺的治疗效果无明显差异;针刺、艾灸均可降低糖尿病大鼠的空腹血糖,并可在一定程度上改善胰岛细胞合成和分泌胰岛素的功能,并可对自由基促使产生过氧化脂质的链式反应进行阻断.提示针刺与艾灸同用时,具有一定的促进作用.

摘要： 以高血压、糖尿病大鼠作为研究对象,初步探讨针刺、艾灸的作用差异,通过对针刺、艾灸、针加灸对二肾一夹型高血压大鼠肾素—血管紧张素—醛固酮系统的影响以及针刺、艾灸、针加灸对糖尿病大鼠(NIDDM)空腹血糖、血清C肽、血清SOD、(MDA)影响的观察,结果显示针刺、艾灸均可降低高血压大鼠的血压,二者共同使用与单独针刺的治疗效果无明显差异;针刺、艾灸均可降低糖尿病大鼠的空腹血糖,并可在一定程度上改善胰岛细胞合成和分泌胰岛素的功能,并可对自由基促使产生过氧化脂质的链式反应进行阻断.提示针刺与艾灸同用时,具有一定的促进作用.

摘要： 以高血压、糖尿病大鼠作为研究对象,初步探讨针刺、艾灸的作用差异,通过对针刺、艾灸、针加灸对二肾一夹型高血压大鼠肾素—血管紧张素—醛固酮系统的影响以及针刺、艾灸、针加灸对糖尿病大鼠(NIDDM)空腹血糖、血清C肽、血清SOD、(MDA)影响的观察,结果显示针刺、艾灸均可降低高血压大鼠的血压,二者共同使用与单独针刺的治疗效果无明显差异;针刺、艾灸均可降低糖尿病大鼠的空腹血糖,并可在一定程度上改善胰岛细胞合成和分泌胰岛素的功能,并可对自由基促使产生过氧化脂质的链式反应进行阻断.提示针刺与艾灸同用时,具有一定的促进作用.

摘要： 公开了使用噻唑烷二酮衍生物及有关的抗高血糖剂治疗葡萄糖耐量降低的患者的新方法，以便防止或延缓这些患者中非胰岛素依赖性糖尿病(NIDDM)的发作。

摘要： 公开了使用噻唑烷二酮衍生物及有关的抗高血糖剂治疗葡萄糖耐量降低的患者的新方法,以便防止或延缓这些患者中非胰岛素依赖性糖尿病(NIDDM)的发作。

摘要： 公开了使用噻唑烷二酮衍生物及有关的抗高血糖剂治疗葡萄糖耐量降低的患者的新方法,以便防止或延缓这些患者中非胰岛素依赖性糖尿病(NIDDM)的发作。

摘要： 公开了使用噻唑烷二酮衍生物及有关的抗高血糖剂治疗葡萄糖耐量降低的患者的新方法，以便防止或延缓这些患者中非胰岛素依赖性糖尿病(NIDDM)的发作。