Memory

摘要： Icariin,a major prenylated flavonoid found in Epimedium spp.,is a bioactive constituent of Herba Epimedii and has been shown to exert neuroprotective effects in experimental models of Alzheimer’s disease.In this study,we investigated the neuroprotective mechanism of icariin in an APP/PS1/Tau triple-transgenic mouse model of Alzheimer’s disease.We performed behavioral tests,pathological examination,and western blot assay,and found that memory deficits of the model mice were obviously improved,neuronal and synaptic damage in the cerebral cortex was substantially mitigated,and amyloid-βaccumulation and tau hyperphosphorylation were considerably reduced after 5 months of intragastric administration of icariin at a dose of 60 mg/kg body weight per day.Furthermore,deficits of proteins in the insulin signaling pathway and their phosphorylation levels were significantly reversed,including the insulin receptor,insulin receptor substrate 1,phosphatidylinositol-3-kinase,protein kinase B,and glycogen synthase kinase 3β,and the levels of glucose transporter 1 and 3 were markedly increased.These findings suggest that icariin can improve learning and memory impairments in the mouse model of Alzheimer’s disease by regulating brain insulin signaling and glucose transporters,which lays the foundation for potential clinical application of icariin in the prevention and treatment of Alzheimer’s disease.

摘要： 2022年3月17日,威德福公司的Memory Raptor套管井评价系统赢得了亚洲海洋技术大会(OTC Asia)2022年亚洲OTC展会新技术奖。Memory Raptor套管井评价系统可以提供先进的油藏管理、地层评价和生产诊断,不需要实时电缆测井设备。这使得该系统在大规模作业、甚至最小的平台、远程设施和卫星井安装中都具有很极大的价值。

摘要： Chronic intake of High Fat Diet (HFD) has the potential of causing a number of metabolic disorders. It is also theorized to be involved in perturbation of gut microbiota. Cannabididol (CBD) and omega 3 are known to possess a number of medicinal usefulness. Their combined use in experimental interventions is quite limited. A total of 15 mice were used for this research divided into three groups of five animals each. Group 1 was administered water and normal chow ad libidum. Group 2 had HFD and water ad libidum. Group 3 had HFD plus CBD (10 mg/kg) and omega 3 (200 mg/kg) all for a total of 12 weeks. They were tested on the elevated plus maze (EPM) and average entry time into the closed arm was recorded. They were also tested on the Y-maze and spontaneous alternations were measured. Thereafter animals were sacrificed and faecal content in the caecum was collected in sterile bottles and cultured for E. coli count. It was found that HFD group at p value 6 ± 4.5) compared to group 1 (1.4 × 106 ± 5.6) and group 3 (1.42 × 106 ± 6.3). The findings revealed that HFD enhanced gut E. coli overgrowth which was reduced by CBD and Omega 3. The memory impairment and anxiety induction by HFD was also significantly ameliorated by CBD and omega 3. E. coli known to be implicated in dementia induction was suppressed by the interventions. Possible mechanisms proposed are actions of CBD and omega 3 on CB1, TRVP and 5HT receptors in reducing anxiety and their antioxidant/anti-inflammatory actions in mitigating the neuro-inflammatory effect of HFD and immune hyperstimulation of E. coli via the gutbrain-axis.

摘要： This paper demonstrates the existence, propagation, transmission, reflection, and interaction of deviatoric stress waves in polymeric fluids for which the mathematical models are derived using conservation and balance laws (CBL) of Classical Continuum Mechanics (CCM) and the constitutive theories are based on the entropy inequality and representation theorem. The physical mechanisms of deformation in polymeric liquids that enable the stress wave physics are identified and are demonstrated to be valid using Maxwell, Oldroyd-B, and Giesekus polymeric fluids, and are illustrated using model problem studies. We assume polymeric fluids to be isotropic and homogeneous at the macro scale so that the CBL of the CCM can be used to derive their mathematical models. For simplicity, we assume the polymeric fluids to be incompressible in the present work.

摘要： Research significance:Dance symbolizes rhythmic body movements to music intending expression of an idea or emotion that delights the performer.Bharatanatyam,an imperative form of Indian Classical dance,has therapeutic implications including enhancement of cognitive function.Neurotrophins belonging to the nerve growth factor family essentially regulate neuronal growth,development and maintenance.The Brain-Derived Neurotrophic Factor(BDNF)is a member of this family.Long-term memory and learning are vitally influenced by BDNF.In Bharatanatyam,new movements are learntand they are practiced until perfection.Every newly learntmovement initially stays in short-term memory and with practice,it reaches the long-term memory.And thus,a favorableincrease in plasma BDNF levels can be associated with Bharatanatyam.In the BDNF gene,rs6265 is a common single nucleotide polymorphism,which results in a valine(Val)being substituted with methionine(Met)in the prodomainat codon 66(Val66Met).This genetic variation affects the BDNF protein’s activity-dependent release.Research methods:With an intention to delve into the link between BDNF gene variants and Bharatanatyam,we conducted an observational research study on 93 participants with their due consent.The study group included 45 dancers and 48 non-dancers.Results anddiscussion:Genotype suggesting optimal BDNF production was proportionately higher in dancers(40%)than non-dancers.Many of the dancers with optimal BDNF genotype expressed a feeling of happiness as their mental status after one hour of dancing and also took up other exercises(like skating/badminton/basketball player etc)as well.While amongst dancers with sub-optimal BDNF genotype,most of them did not take up any other exercise(like skating/badminton/basketball player etc)andalso expressed a blank feeling as their mental status after one hour of dancing.Thus,BDNF has an evident role in the formation of new learning and memory.

摘要： Background:Learning,memory disorders,and pain,especially Alzheimer’s,are some of the factors that affect today’s societies and disrupt their lives.On the other hand,the type of diet with hot and cold temperament is associated with memory and pain;therefore,inthis study,the effect of Cinnamon extract(hot temperament)and Lentil extract(cold temperament)on pain and memory was investigated.Methods:Animals were randomly divided into three groups including the control group,a group that received Cinnamon extract,and rats who were treated with lentil extract at a dose of 260 intraperitoneally.Then,24 hours after the last injection,pain and memory tests were performed for each.Results:The results of the Passive avoidance test(PAT)(shuttle box)showed that the latency time in going to the dark chamber in the group that received Lentils compared to cinnamon was significantly reduced(P<0.01).The retention time of animals in the dark chamber was significantly increased in the group that received Lentil extract in comparison with the Cinnamon group(P<0.001).The number of visits to the dark compartment significantly decreased in the group that received Cinnamon extract compared to the Lentil group(P<0.01).Pain test results also showed that the Lentil group had significantly less pain tolerance than the Cinnamon group(P<0.001).Conclusion:In this study,Cinnamon compared to Lentil increased memory and pain tolerance;therefore,it can be said that hot and cold temperament probably affects memory and learning as well as the level of pain tolerance.

摘要： Using the conflict principle of the Stroop task, “effect of interference in color naming”, the present study proposes to create a computational version of the emotional Stroop task, called TREFACE, for its acronyms in Portuguese “Teste de Reconhecimento de Expressões Faciais com Conflito Emocional” (Facial Expression Recognition Test with Emotional Conflict). In this protocol, four fixed styles of presentation were generated according to the condition: Congruent Word Reading, Incongruent Word Reading, Congruent Recognition of Face Expression and Incongruent Recognition of Face Expression, counterbalanced in terms of each facial expression, word and gender of the photo character. Forty-two healthy volunteers completed the task. Results revealed that a task associated with word reading allows better performance than a task associated with face recognition. It was also identified that in the congruent condition, there is an advantage in terms of the correct responses. Additionally, the data regarding recognition of face expression showed greater difficulty when the image was not congruent with the word. In general, the results suggest that the emotional attribute can compromise the ability to recognize the faces, reaching the functioning of mechanisms such as cognitive control and regulation of emotions. Thus, the TREFACE paradigm can be considered a good assessment tool for monitoring emotional conflict, in addition to presenting itself as a new instrument in Portuguese language for assessing emotional working memory in healthy individuals and, eventually, in different pathologies that affect the functioning of cortical areas related to executive functions.

摘要： Aspect’s extraction is a critical task in aspect-based sentiment analysis,including explicit and implicit aspects identification.While extensive research has identified explicit aspects,little effort has been put forward on implicit aspects extraction due to the complexity of the problem.Moreover,existing research on implicit aspect identification is widely carried out on product reviews targeting specific aspects while neglecting sentences’dependency problems.Therefore,in this paper,a multi-level knowledge engineering approach for identifying implicit movie aspects is proposed.The proposed method first identifies explicit aspects using a variant of BiLSTM and CRF(Bidirectional Long Short Memory-Conditional Random Field),which serve as a memory to process dependent sentences to infer implicit aspects.It can identify implicit aspects from four types of sentences,including independent and three types of dependent sentences.The study is evaluated on a largemovie reviews dataset with 50k examples.The experimental results showed that the explicit aspect identification method achieved 89%F1-score and implicit aspect extraction methods achieved 76%F1-score.In addition,the proposed approach also performs better than the state-of-the-art techniques(NMFIAD andML-KB+)on the product review dataset,where it achieved 93%precision,92%recall,and 93%F1-score.

摘要： The human visual system,dependent on retinal cells,can be regarded as a complex combination of optical system and nervous system.Artificial retinal system could mimic the sensing and processing function of human eyes.Optically stimu-lated synaptic devices could serve as the building blocks for artificial retinas and subsequent information transmission system to brain.Herein,photonic synaptic transistors based on polycrystalline MoS_(2),which could simulate human visual perception and brain storage,are presented.Moreover,the photodetection range from visible light to near-infrared light of MoS_(2)multilayer could extend human eyes’vision limitation to near-infrared light.Additionally,the photonic synaptic transistor shows an ultrafast speed within 5μs and ultralow power consumption under optical stimuli about 40 aJ,sever-al orders of magnitude lower than biological synapses(50 ms and 10 fJ).Furthermore,the backgate control could act as emotional modulation of the artificial brain to enhance or suppress memory function,i.e.the intensity of photoresponse.The proposed carrier trapping/detrapping as the main working mechanism is presented for the device.In addition,syn-aptic functionalities including short synaptic plasticity,long synaptic plasticity and paired-pulse facilitation could be suc-cessfully simulated based on the prepared device.Furthermore,the large difference between short synaptic plasticity and long synaptic plasticity reveals the better image pre-processing function of the prepared photonic synapses.The classical Pavlovian conditioning associated with the associative learning is successfully implemented as well.Therefore,the efficient and rich functionalities demonstrate the potential of the MoS_(2)synaptic device that integrates sensing-memory-preprocessing capabilities for realizing artificial neural networks with different emotions that mimic human retina and brain.

摘要： Effective vaccination in duces memory T cells,which protect the host against pathogen re-infecti ons.Therefore,detection of memory T cells is essential for evaluating vaccine efficacy,which was originally dependent on cytokine induction assays.Currently,two isoforms of CD45 tyrosine phosphatase,CD45RO expression and CD45RA exclusion(CD45RO^(+)/CD45RA^(-)) are used extensively for detecting memory T cells in cattle.The CD45RO^(+)/CD45RA^(-) markers were first established in humans around three decades ago,and were adopted in cattle soon after.However,in the last two decades,some published data in humans have challenged the initial paradigm,and required multiple markers for identifying memoryT cells.On the contrary,memoryT cell detection in cattle still mostly relies on CD45RO^(+)/CD45RA^(-)despite some con troversial evidence.In this review,we summarized the current literature to exami ne if CD45RO^(+)/CD45RA^(-)are valid markers for detecting memoryT cells in cattle.It seems CD45RA and CD45RO(CD45RA/RO)as markers for identifyi ng bovine memoryT cells are questi on able.

摘要： 本申请公开了一种用于Memory VRTT动态响应测试的上位机系统及其工作方法，该上位机系统包括：上位机、待测板卡、逻辑开关接线模块、数字万用表、示波器、VRTT Tool和数据处理模块。待测板卡、逻辑开关接线模块、数字万用表和示波器构成自校正实现区，待测板卡、示波器和VRTT Tool构成数据采集区，数据处理模块构成数据处理区。该方法包括：搭建测试环境；按照Memory VRTT标准进行上电；进行探棒自校正和探棒精度自校正；启动初始测试；判断初始测试结果是否符合SPEC标准；如果是，利用数据处理模块生成测试报告；否则进行调试；调试完毕重新进行探棒自校正和探棒精度自校正，直到获取测试报告；按照Memory VRTT标准下电。通过本申请，能有效提高测试效率和测试结果的准确性。

摘要： 本发明公开了一种Memory芯片封装方法及结构，通过在长条形芯片宽度方向延伸生成无功能结构层，在无功能结构层的底部阵列支撑凸点，阵列形成的支撑凸点与长条形芯片底部的功能凸点高度一致，利用支撑凸点使长条形芯片整体通过支撑凸点配合功能凸点支撑，然后通过倒装贴片方法将延伸有无功能结构层的长条形芯片贴合到基板衬底的引脚上，采用回流焊将长条形芯片及其无功能结构层底部的支撑凸点与基板衬底的引脚同时焊接，一体封装成型，支撑凸点与引脚焊接，将封装应力分散到无功能结构层上的支撑凸点上，避免了功能凸点因应力而脱落，大大降低长条形芯片底部功能凸点受到应力的影响，提高了长条形芯片结构的安装稳定性。

摘要： 本发明提供一种新型Memory电特性测试设备自动化清洁装置，包括待机文件盒，待机文件盒进入到设备指定文件盒工位，文件盒工位通过传感器反馈信号给工控机，工控机传递电信号给继电器，继电器供电至离子风棒，离子风棒继文件盒工位工作，形成工作循环；工控机传递电信号给电磁阀，电磁阀控制吸尘装置进行作业，吸尘装置同时接受电磁阀和文件盒工位反馈信息传递进行粉尘收集；本发明通过文件盒的清洁工作在设备运行时自动进行，员工不需要额外增加计算机处理动作，避免因搬运或人员作业实物导致品质事故发生；采用软件开发将清洁装置信号与电性测试设备软件结合，同时满足不同尺寸不同型号内存及区分设备运行转态进行测试清洁。

摘要： 本发明公开了一种基于Android车机的CPU和Memory占用数据监测分析方法及系统，属于网络数据监测技术领域，通过Android调试桥(adb)命令行工具，与Android设备进行通信，再通过调用dumpsys工具来获取android设备中各个进程的CPU及Memory的占用数据信息，通过python程序对获取的数据信息进行处理，再传递至QT界面，形成一套可以实时监测分析CPU和Memory占用数据情况的系统，包括：实时监测各进程CPU和Mmeory数据信息；对CPU和Memory的数据进行文件储存；对已储存的CPU和Memory数据文件能进行导入分析；以折线图的形式在程序中进行展示；能够筛选所需要分析的进程数据。

摘要： 本发明提供了一种针对Shadow Memory内存泄漏检测机制的内存压缩方法，属于计算机应用领域。本发明方法针对对象尺寸较小带来的内存开销较大的问题，使用了对象信息模糊表示的机制——对象融合，来进行Shadow Memory内存压缩，对最小尺寸为k字节的对象，若相邻两个对象的指针相差不超过2k字节，则两对象共用一个对象标识单元；同时为了消除由此带来的对象漏报，提供了两种方案：输出补充信息，随机覆盖并结合多次运行泄漏检测的输出结果来解决对象漏报。本发明方法在泄漏检测的准确性和内存负载之间做出适当的权衡，使得泄漏检测模块的内存消耗降低一半，也减少了对泄漏对象排查的工作量，加快了泄漏检测效率。

摘要： 本实用新型公开了一种Memory测试治具，包括测试板，测试板的顶部开设有安装槽，测试板的两侧均固定连接有导向轨，导向轨的内腔滑动连接有导向块，安装槽的内腔转动连接有丝杆，丝杆的表面螺纹连接有套筒，套筒的顶端固定连接有支撑杆，支撑杆的顶端固定连接有移动板，测试板的一侧固定安装有驱动电机，测试板顶部远离驱动电机的一侧固定连接有放置板，放置板的顶部固定连接有夹持框，夹持框内腔远离驱动电机的一端固定安装有压力传感器，夹持框内腔的两侧均通过销杆转动连接有连杆，连杆远离销杆的一端固定连接有夹板，本实用新型一种Memory测试治具，实现对不同尺寸的内存进行夹持，增加设备的适应性，使得夹持更加稳定。

摘要： 本发明涉及一种多工位并发测试的memory烧写时间系统及其烧写方法，属于芯片检测技术领域。本发明的系统包括存储单元、时序发生器、数据寄存器、测试图形发生器、串行时序发生器、时间测量单元和电子管脚。本发明不需要为每个被测器件提供独立的处理器，降低了测试成本；本发明可以多工位完成烧写时间的测试；本发明通过PATTERN文件控制，编程简便。

摘要： 本发明公开一种多核CPU的memory测试方法，属于memory测试领域。多核CPU在MBIST测试状态下，当状态机FSM接收到开始指令后同时选通每个内核中第一类memory，状态机FSM控制测试向量产生电路产生针对第一类memory的测试向量，连同对应该测试向量的Address和Control信号同步送到第一类memory，再同时读取写入第一类memory的测试向量，并将读取的结果合并后送到比较器中；比较器将其和测试向量产生电路产生的期望值进行对比；如果对比结果不同，比较器输出低电平表示测试失败；如果对比结果相同，比较器输出高电平测试继续。本发明大大提高了MBIST的测试效率，解决了现有技术在测试memory时测试速度和CPU面积、功耗不能同时兼顾的问题。当CPU的内核越多这种优势越明显。

摘要： 本发明涉及微处理器技术领域，具体涉及一种memory set的优化策略的实现方法及系统，包括store_buffer模块、pipeline模块、stream_model_dector模块和WCB模块。解决了现有技术中由于Miss，需要向L2发出reload请求，然后L2返回reload数据，最后再把store的数据和reload的数据一同写入D_cache中，这样会导致latence太长；由于向L2中发出了请求，其实reload回来的数据并没有用，这样就无缘无故的加大的了L2请求的带宽；造成D_cache的污染，并且造成的污染数据会很大，对D_cache的命中率将会有大幅度的下降的问题。本发明减少了latence，同时降低了L1对L2请求的带宽，并且不会造成L1_cache的污染，不会对D_cache的命中率有负面影响，具有很强的市场应用前景。

摘要： 本发明涉及微处理器技术领域，具体涉及一种mmu和ifu读取memory中数据的实现方法及系统，所述方法将mmu和ifu读取数据的请求直接发往L2；如果在L2中发现有dirty数据在L1_cache中，则通过L2向L1发出snoop请求，获取dirty数据，进而读取memory的最新数据。本发明mmu和ifu读取数据的请求不用占用L1的pipeline资源，且mmu和ifu不会对L1_cache的污染，不会对指令操作数的命中率有影响，具有很强的创造性。