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分泌型IgA

分泌型IgA的相关文献在1991年到2022年内共计90篇,主要集中在基础医学、内科学、儿科学 等领域,其中期刊论文77篇、会议论文4篇、专利文献926772篇;相关期刊67种,包括大连大学学报、北华大学学报(自然科学版)、护士进修杂志等; 相关会议4种,包括第十届全国微生态学学术会议、中国环境诱变剂学会第14届学术交流会议、中国畜牧兽医学会2010学术年会暨第二届中国兽医临床大会等;分泌型IgA的相关文献由259位作者贡献,包括任杰、刘晶、刘杰等。

分泌型IgA—发文量

期刊论文>

论文:77 占比:0.01%

会议论文>

论文:4 占比:0.00%

专利文献>

论文:926772 占比:99.99%

总计:926853篇

分泌型IgA—发文趋势图

分泌型IgA

-研究学者

  • 任杰
  • 刘晶
  • 刘杰
  • 宋静慧
  • 托娅
  • 熊英
  • 谢彩霞
  • 郑晶晶
  • 金海甲
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 胡伟; 文丽; 邓小红; 许建章
    • 摘要: 本文对人源性和猪源性的冠状病毒进行综述,让养猪人足不出户了解冠状病毒以及它对我们的影响和危害,从而避免或减少冠状病毒对我们造成的损失.
    • 周会霞; 李银华
    • 摘要: 目的:分析分泌型IgA联合常规抗感染药物治疗小儿上呼吸道感染临床疗效及炎症反应.方法:选择2019年4月-2020年4月本院收治上呼吸道感染患儿66例临床资料,按随机数表分为两组,对照组33例采用常规抗感染药物治疗,研究组33例使用分泌型IgA联合常规抗感染药物治疗,对两组临床疗效及炎症反应进行比较.结果:研究组显效63.64%,对照组显效36.36%,研究组临床总有效96.97%比对照组75.76%高,差异具统计意义(P<0.05);且研究组CRP、IL-1、IL-8等指标分别是(2.99±0.37)mg/L、(5.98±0.74)pg/mL、(9.65±1.14)pg/mL,均比对照组低,差异具统计意义(P<0.05);研究组SAA、Chemerin等指标比对照组低,Leptin指标比对照组高(P<0.05);研究组IgA(6.73±0.71)、IgG(9.78±1.51)、IgM(5.29±0.61)等指标均比对照组高,差异具统计意义(P<0.05).结论:临床采用分泌型IgA联合常规抗感染药物治疗上呼吸道感染患儿,可有效抑制患儿全身的炎症反应,还能增强其免疫应答功能,临床上值得推广使用.
    • 熊英; 马宏莲
    • 摘要: 目的 探究血清白介素(interleukin,IL)-6、IL-8与宫颈分泌型免疫球蛋白A(secretory immuno-globulin A,sIgA)联合检测对女性慢性盆腔炎的诊断价值.方法 收取2014年5月—2017年12月在鄂州市中心医院经腹腔镜确诊为慢性盆腔炎的女性患者130例为病例组,与同期在该院行体检的健康女性150例为对照组,比较2组女性的血清IL-6、IL-8与宫颈sIgA水平,分析3者表达水平与慢性盆腔炎患者临床病例特征之间的关系.采用受试者工作特征曲线(receiver operating characteristic,ROC)分析血清IL-6、IL-8与宫颈sIgA对女性慢性盆腔炎的诊断价值,多元Logistic回归计算3者预测女性慢性盆腔炎发病的风险比(odds ratio,OR)及95%置信区间(confidence interval,CI).结果 与对照组比较,病例组女性的血清IL-6、IL-8与宫颈sI-gA水平升高,差异比较具有统计学意义(t=3.967,P=0.003;t=4.013,P<0.001;t=2.986,P=0.002).血清IL-6、IL-8在输卵管炎中增高最为显著,而宫颈sIgA在子宫体炎中增高最为显著.ROC结果表明,血清IL-6、IL-8与宫颈sIgA鉴别诊断女性慢性盆腔炎的灵敏度/特异性分别为84.9%/73.7%、77.5%/81.3%和38.9%/92.3%;诊断界值分别为:94.6 pg/mL、88.6 pg/mL和70.2μg/mL;联合3项指标的灵敏度为82.8%,特异度为93.6%.多元Logistic回归分析表明,高IL-6、IL-8、sIgA水平均是女性慢性盆腔炎发病的独立危险因素.结论 联合血清IL-6,IL-8与宫颈sIgA 3项指标可协助女性慢性盆腔炎的诊断,同时,3者对女性慢性盆腔炎发病风险的预测也具有潜在价值.
    • 杨琳东; 黄红艳
    • 摘要: 目的:探讨分泌型IgA应用上呼吸道感染患儿对炎症反应和免疫功能指标的影响.方法:收集在本院接受治疗的反复发作上呼吸道感染患儿80例进行回顾性分析,分为接受常规抗感染治疗的对照组43例 、接受分泌型IgA联合常规抗感染治疗的分泌型IgA组37例.对比两组治疗前 、治疗7 d后血清炎症因子 、免疫球蛋白含量及外周血Th1/Th2免疫应答指标水平的差异.结果:治疗前,两组血清炎症因子 、免疫球蛋白含量及外周血Th1/Th2免疫应答指标水平比较,差异无统计学意义(P>0.05).治疗7 d,分泌型IgA组血清中炎症因子肿瘤坏死因子 α(TNF-α)、白介素-2(IL-2)、白介素-18(IL-18)的含量低于对照组(P<0.05),血清中免疫球蛋白IgE的含量低于对照组,IgG2、IgG4的含量高于对照组(P<0.05),外周血中Th1细胞的分布比例及Th1/Th2比值高于对照组,Th2细胞分布比例低于对照组(P<0.05).结论:反复上呼吸道感染患儿在常规抗感染药物治疗同时加入分泌型IgA进行联合治疗,可进一步抑制机体炎症反应并均衡免疫应答功能.
    • 熊英; 马宏莲
    • 摘要: 目的 探究血清白介素(interleukin,IL)-6、IL-8与宫颈分泌型免疫球蛋白A(secretory immunoglobulin A,sIgA)联合检测对女性慢性盆腔炎的诊断价值.方法 收取2014年5月-2017年12月在鄂州市中心医院经腹腔镜确诊为慢性盆腔炎的女性患者130例为病例组,与同期在该院行体检的健康女性150例为对照组,比较2组女性的血清IL-6、IL-8与宫颈sIgA水平,分析3者表达水平与慢性盆腔炎患者临床病例特征之间的关系.采用受试者工作特征曲线(receiver operating characteristic,ROC)分析血清IL-6、IL-8与宫颈sIgA对女性慢性盆腔炎的诊断价值,多元Logistic回归计算3者预测女性慢性盆腔炎发病的风险比(odds ratio,OR)及95%置信区间(confidence interval,CI).结果 与对照组比较,病例组女性的血清IL-6、IL-8与宫颈sI-gA水平升高,差异比较具有统计学意义(t=3.967,P=0.003;t=4.013,P<0.001;t=2.986,P=0.002).血清IL-6、IL-8在输卵管炎中增高最为显著,而宫颈sIgA在子宫体炎中增高最为显著.ROC结果表明,血清1L-6、IL-8与宫颈sIgA鉴别诊断女性慢性盆腔炎的灵敏度/特异性分别为84.9%/73.7%、77.5%/81.3%和38.9%/92.3%;诊断界值分别为:94.6 pg/mL、88.6 pg/mL和70.2 μg/mL;联合3项指标的灵敏度为82.8%,特异度为93.6%.多元Logistic回归分析表明,高IL-6、IL-8、sIgA水平均是女性慢性盆腔炎发病的独立危险因素.结论 联合血清IL-6,IL-8与宫颈sIgA 3项指标可协助女性慢性盆腔炎的诊断,同时,3者对女性慢性盆腔炎发病风险的预测也具有潜在价值.
    • 熊英; 秦燕
    • 摘要: 收取慢性盆腔炎(PID)女性为病例组,健康女性为对照组,比较两组女性的血清长链非编码RNA(LncRNA)-ROR、微小RNA-29(miR-29)与宫颈分泌型IgA(SIgA)水平.相比于对照组,病例组血清LncRNA-ROR、miR-29与宫颈SIgA水平升高,差异具有统计学意义(P<0.05).受试者工作特征曲线(ROC)结果表明,血清Ln-cRNA-ROR、miR-29与宫颈SIgA鉴别诊断PID的灵敏度/特异性分别为74.9%/48.7%、76.5%/83.3%和78.1%/92.3%;诊断界值分别为:74.6μg/mL、34.6(-log)和16.2(-log);联合三项指标的灵敏度为88.8%,特异度为91.6%.二元Logistic回归分析表明,高LncRNA-ROR、miR-29与宫颈SIgA水平是PID发病的独立危险因素.联合血清LncRNA-ROR、miR-29与宫颈SIgA三项指标可协助PID的诊断,同时,三者对PID发病风险的预测也具有潜在价值.
    • 侯洪涛; 裘艳梅; 冯佳; 蔡聪会; 张建; 胡义亭
    • 摘要: 目的 探讨姜黄素对非酒精性脂肪肝病( NAFLD)大鼠肠道 sIgA及氧化应激的影响.方法将雄性SD大鼠30只随机分为3组:正常对照组10只、高脂组10只、高脂+姜黄素组10只.高脂组、高脂+姜黄素组给予高脂饲料喂养16周,其中高脂+姜黄素组在高脂喂养8 周后,给予姜黄素灌胃200 mg/( kg· d),1次/d.光学显微镜观察小肠黏膜及肝脏病理变化;鲎试剂测定门静脉脂多糖( LPS)水平,酶联免疫法测定肠道sIgA含量,分光光度法测定血浆二胺氧化酶( DAO)活性,羟胺法测定小肠超氧化物歧化酶( SOD)活性,比色法测小肠丙二醛(MDA)水平,全自动生化仪检测血清ALT、AST.结果 光镜下,对照组大鼠小肠黏膜及肝组织无明显异常,高脂组小肠黏膜绒毛稀疏,部分绒毛出现断裂、缺损,肝细胞内可见较多脂滴浸润,并有气球样变,高脂+姜黄素组小肠绒毛比较完整,绒毛缺失减少,肝细胞脂肪变明显减轻.与对照组比较,高脂组大鼠血AST、ALT、DAO、LPS及小肠MDA水平明显升高,小肠SOD活性及肠道sIgA下降,差异均有统计学意义(P<0.05);与高脂组比较,高脂+姜黄素组大鼠血AST、ALT、DAO、LPS及小肠MDA降低,SOD活性及肠道sIgA升高,差异均有统计学意义(P<0.05).结论 姜黄素可能通过增加肠道sIgA水平、改善肠黏膜氧化应激状态而减轻NAFLD时肠黏膜屏障损伤.%Objective To investigate the effects of curcumin (Cur) on intestinal sIgA and oxidative stress in rats with nonalcoholic fatty liver disease (NAFLD).Methods Thirty male SD rats were randomly divided into normal control group (Group NC), high fat group (Group HF) and Group HF+Cur.High fat diet were given in Group HF group and HF+Cur for 16 weeks.After 8 weeks of high fat feeding in Group HF +Cur, curcumin [200 mg/(kg· d)] were given with lavage for 8 weeks.The pathological changes of intestinal mucosa and liver were observed by optical microscope .The lipopolysaccharide (LPS) of portal vein blood was measured by limulus test .Intestinal sIgA levels were determined by en-zyme linked immunosorbent assay (ELISA).The activity of plasma diamine oxidase (DAO) was determined by spectro-photometric method.The activity of SOD in intestine was measured by hydroxylamine method , and the content of MDA in intestine was measured by colorimetry .The serum levels of alanine aminotransferase ( ALT) and aspartate aminotrans-ferase (AST) were detected by automatic biochemical analyzer .Results Under light microscope , there was no obvious abnormality in small intestinal mucosa and liver in Group NC .In Group HF, intestine mucosa villi were sparse , some of them were broken and defect ; fat droplets infiltration and balloon -like changes in hepatocyte could be seen .In Group HF+Cur, intestine villi were more complete than Group HF , the loss of villi was decreased , and hepatocellular steatosis was significantly reduced.Compared with Group NC, the blood levels of AST , ALT, DAO, and LPS and MDA contents of in-testine in HF group were obviously increased , SOD activity of intestinal and sIgA levels of intestinal were decreased (P<0.05).Compared with HF group, the blood levels of AST, ALT, DAO and LPS, and MDA content of intestine in Group HF+Cur were significantly lowered; and SOD activity and sIgA level in intestine were significantly elevated (P<0.05). Conclusion Curcumin can reduce intestinal mucosal barrier injury by increasing sIgA of intestinal mucosa and improving oxidative stress of intestinal mucosa in rats with NAFLD .
    • 李春梅
    • 摘要: 目的:探讨分泌型Ig A联合常规抗感染药物治疗对小儿上呼吸道感染炎症反应、免疫应答的影响.方法:选取2016年2月~2017年2月在本院就诊的上呼吸道感染小儿130例,经随机数表法将其分为对照组、分泌型Ig A组各65例.对照组接受常规抗感染药物治疗,分泌型Ig A组接受分泌型Ig A联合常规抗感染药物治疗,持续1周.对比两组患者治疗前后血清中常规炎症因子、脂肪炎症因子、免疫球蛋白含量的差异.结果:治疗前,两组血清中常规炎症因子、脂肪炎症因子、免疫球蛋白含量的差异无统计学意义.治疗1周后,分泌型IgA组血清中常规炎症因子CRP、IL-1、IL-8的含量低于对照组;血清中脂肪炎症因子SAA、Chemerin的含量低于对照组,Leptin的含量高于对照组;免疫球蛋白IgA、IgG、IgM的含量高于对照组.结论:小儿上呼吸道感染接受分泌型IgA联合常规抗感染药物治疗,可有效抑制全身炎症反应并增强体液免疫应答.%Objective:To investigate the effect of secretory IgA combined with conventional anti-infectious drugs on in-flammatory response and immune response in children with upper respiratory tract infection .Methods:A total of 130 children with upper respiratory tract infection who were treated in the hospital between February 2016 and February 2017 were divided into control group and secretory IgA group by random number table method ,each group with 65 cases .Control group received routine anti-infectious drug treatment ,and secretory IgA group received the secretory IgA combined with conventional anti-in-fectious drug treatment ,which lasted for 1 week .The differences in serum levels of routine inflammatory factors ,fat inflam-matory factors and immunoglobulin were compared between the two groups before and after treatment .Results:There was no statistically significant difference in serum levels of normal inflammatory factors ,fat inflammatory factors and immunoglobulin between the two groups before treatment .After 1 week of treatment ,serum conventional inflammatory factors CRP ,IL-1 and IL-8 levels of secretory IgA group were lower than those of control group ;serum fat inflammatory factors SAA and Chemerin levels were lower than those of control group whereas Leptin level was higher than that of control group ;serum immunoglobu-lin IgA ,IgG and IgM contents were higher than those of control group .Conclusions:The secretory IgA combined with conven-tional anti-infectious drugs can effectively inhibit the systemic inflammatory response and enhance the humoral immune re-sponse in children with upper respiratory tract infection .
    • 曾婉; 张军军
    • 摘要: IgA肾病(IgAN)是我国最常见的原发性肾小球疾病,多发生于呼吸道或消化道感染后.有学者推测黏膜免疫可能与IgAN的发生相关,而分泌型IgA (SIgA)在黏膜免疫中扮演着重要的角色,本文就SIgA在IgAN发病中的研究进展做一综述.%Immuno globulin A nephropathy is the most common primary glomerular disease in China.IgA nephropathy occurs frequently after respiratory or digestive tract infections.some scholars speculate that mucosal immunity is related to IgA nephropathy.Secretory IgA plays an important role in IgA nephropathy.This article reviews the progress of secretory IgA in the pathogenesis of Secretory IgA nephropathy.
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