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摘要： Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.

摘要： China's commitment and contribution to multilateralism is laudable.IN his Lunar New Year greetings video,United Nations Secretary-General António Guterres took the opportunity on Chinese New Year’s Eve to commend China for its commitment to multilateralism.The global battle against the COVID-19 pandemic,as well as climate change,continues in February 2022,which has also seen heated and ominous disagreements that threaten dire conflict.All present challenges unprecedented in recent history.Amid this turmoil,Guterres declared that the Olympic spirit,as represented by the Beijing 2022 Winter Olympics,“shines as a beacon of human solidarity.”Such acknowledgement and words of goodwill from the world’s top diplomat are merited in light of China’s key contributions to multilateralism over decades,most specifically during the last several years.They are evident in three distinctive examples.

摘要： Adult neurogenesis is the life-long process of neural stem cell proliferation,differentiation into neurons,migration,and incorporation into the existing neuronal circuits.After decades of research,it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult ontogeny.Cerebrospinal fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully elucidated.Proteomic studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular composition.Comparative studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in adulthood.In this review,we performed literature-based data mining in studies using liquid chromatography-tandem mass spectroscopy that analyzed cerebrospinal fluid samples from healthy adult humans(Homo sapiens);mice(Mus musculus);sheep(Ovis aries);chickens(Gallus gallus);and two parrot species,the budgerigar(Melopsittacus undulatus)and cockatiel(Nymphicus hollandicus).We identified up to 911 proteins represented in cerebrospinal fluid,involved in various pathways regulating adult neurogenesis.However,only 196 proteins were common across humans,mice,and birds.Pathway components involved in nervous system development,cell migration,and axonal guidance were commonly evident in all species investigated so far.Extensive bioinformatic analysis revealed that the universally over-represented pathways involved L1 cell adhesion molecule protein interactions,cell-adhesion molecules,signals regulating extracellular matrix remodeling,regulation of insulin growth factor signaling,axonal guidance,programmed cell death,immune signaling,and post-translational modifications.Most of the reported proteins are part of extracellular vesicles enriched in cerebrospinal fluid.However,the information presently available is still highly fragmentary,and far more questions persist than are answered.Technological advances will allow cerebrospinal fluid comparative proteomic research to delve into the fundamental processes of adult neurogenesis and eventually translate this research into any regenerative interventions.

摘要： China and the Shared Human Future:Exploring Common Values and Goals Author Martin Albrow Hardcover,445 pages Published by Global Century Press British sociologist Martin Albrow's latest book-China and the Shared Human Future:Exploring Common Values and Goals-was recently launched in Beijing,which coincided with the t hree-day Lon don Book Fair 2022.The book has much to commend.

摘要： Progesterone is an endogenous steroid hormone with an important role for the physiology of the female reproductive system and the mammary gland.It has additional significant actions in other tissues,such as the cardiovascular system,the central nervous system,and bones.The present article explores potential clinical implications from the addition of bioidentical progesterone to genderaffirming treatment of trans women.For this purpose,it provides an overview of the physiological action of progesterone in target tissues and speculates on possible benefits for gender transitioning.Progesterone is expected to exert moderate anti-androgen action through suppression of the hypothalamicpituitary-gonadal axis and inhibition of the conversion of testosterone to dihydrotestosterone.It may also contribute to breast maturation.In the long-term,progesterone could prevent bone loss and protect cardiovascular health.The potential benefits are mainly inferred by extrapolating evidence from biological actions in cisgender women and medical assumptions and hence,clinicians need to be cautious when applying these data into practice.Further research is needed to ascertain the efficacy and safety of progesterone in current hormonal regimens.

摘要： Dear Editor,This letter is concerned with human parsing based on part-wise semantic prediction.Human body can be regarded as a whole structure composed of different semantic parts,and the mainstream single human parser uses semantic segmentation pipeline to solve this problem.

摘要： Dear editor:You may have often come across with differences between Islamic and secular societies regarding euthanasia,Do Not-Resuscitation,postmortem care,abortion,and the use of artificial respiration[1-6].These differences originate from Islamic view’s human dignity.According to Islam,human beings have dignity because they were created by God[5,6].Therefore,life is trusted to us by God and humans cannot decide to keep or give it up and must safe keep it.This is in contrast with secular view,which attributes dignity to free will and hence,regards life as a right at the possession of human beings.From the viewpoint of Islam,God has trusted human being with their lives and mankind finds dignity through this trust.According to Islamic views,Muslims are not entitled to make decisions about their lives,for it belongs to God and it has merely been left to us in trust[7].

摘要： Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.Papers regarding components of food especially nutrients and non-nutrient bioactive compounds(with putative health benefits)are welcomed.FSHW aims to unveil the correlations between food science and human health through the dissemination of both fundamental and applied research outcomes worldwide.

摘要： Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.

摘要： 近年来,数字技术快速发展并得到广泛应用,在给人们带来便利的同时,也产生了流程僵化等问题,尤其在应对突发事件时,更凸显了流程僵化导致的系统的脆弱性.由此,加快从刚性自动化向柔性自主性的转变,实现以人为本的柔性设计,并构建面向未来智造的人系统集成系统成为当下的研究重点.«DesignforFlexibility:aHumanSystemsIntegrationApproach»一书阐述了柔性设计的概念、方法和过程,提出社会技术系统柔性分析框架,介绍了人系统集成(HumanGsystemintegration,HSI)这一新兴学科,为处理突发事件并提出问题解决方案提供了工具和方法,相应研究成果有望为提高设计和操作柔性、促进人机交互效率、构建可持续发展的社会技术系统提供理论支撑.HSI作为一门新学科,旨在将以人为本的设计理念融入复杂系统工程的全生命周期过程,为以人为本的柔性设计提供了方法论,同时也为人本设计、人本智造等研究提供了参考.

摘要： 本发明公开了一种Human残留DNA片段分析检测试剂盒，合成三套taqman探针针对不同长度的扩增片段(约99bp、200bp、300bp)来定量检测分析样本中Human残留DNA片段的大小分布情况，建立了针对于293T细胞DNA残留片段分布检测的方法，该检测方法的特异性强，扩增效率高，灵敏度高，可重现性好，而且其中试剂的冻融稳定性突出，与不同参比ROX协同作用，可用于多种PCR仪器，适用范围广，时限长。且该试剂盒检测快速，特异性强，性能可靠，最低检测限可以达到fg水平。此外，有效简化了qPCR反应操作的反应液配置时的操作步骤，可用于重组蛋白药、抗体药、疫苗、细胞与基因药物等领域中定量检测各种生物制品的中间品、半成品及成品中Human宿主细胞DNA残留片段大小分布及含量。

摘要： 本发明公开了一种Human DNA残留检测试剂盒，通过在常规PCR基础上加入特定荧光标记引物探针制备得到Human DNA残留检测试剂盒，实现了对Human残留DNA的定量分析。该试剂盒的扩增效率高，特异性强，精确度、灵敏度高，可重现性好，具有优异的冻融稳定性。试剂盒简化qPCR反应操作的反应液配置时的操作步骤，减少操作者的工作量，节约整个操作时间，且若是用于连续性检测，可使检测结果更具比较性。此外，该试剂盒通过两步法反应快速扩链，检测速度快，专一性强，性能可靠，最低检测限可以达到fg水平。可用于重组蛋白药、抗体药、疫苗、细胞与基因药物等领域中定量检测各种生物制品的中间品、半成品及成品中Human宿主细胞DNA。