HFMD

摘要： Enteroviruses(EVs)belong to the family Picornaviridae and are divided into 15 species:enterovirus A–L and rhinovirus A–C(http://www.picornaviridae.com).EV-C consists of 23 serotypes,including poliovirus 1-3,CVA1,CVA11,CVA13,CVA17,CVA19,CVA20,CVA21,CVA22,CVA24,EVC95,EV-C96,EV-C99,EV-C102,EV-C104,EV-C105.

摘要： 手足口病(HFMD)是由肠道病毒(EV)感染引起的主要在儿童中传播的急性传染病,HFMD发病率为37.01/10万~205.06/10万,近年报告病死率在6.46/10万~51.00/10万之间[1]。引起HFMD的肠道病毒有20多个血清型,A组柯萨奇病毒(CV-A)和肠道病毒A组71型(EV71)等新型肠道病毒是引起HFMD的主要致病病原体[2]。

摘要： 手足口病(HFMD)发病与日均气温存在密切联系,为了解2010~2015年泉州市HFMD分布特征及日均气温对HFMD发病人次的影响,本论述采用基于准泊松分布的广义线性模型(GLM)结合分布滞后非线性模型(DLNM),在控制星期几效应、长期趋势、气象要素等混杂因素后,计算相对于日均气温P50,在滞后21 d内对HFMD发病人次的影响。结果表明:2010~2015年泉州市丰泽区、鲤城区、洛江区累计报告HFMD发病人次23 960人,发病主高峰在4~7月。日均气温累积滞后21 d对HFMD发病人次的影响呈非线性(近似‘M’形),存在两个峰值,出现在32.2°C(相对危险度RR=1.848,95%CI:1.260~2.709)和12.1°C(RR=1.664,95%CI:1.105~2.507)。高温和低温均对HFMD有发病风险,且滞后效应明显.极端气温均在滞后第1 d起RR值大于1,第5百分位气温10.5°C和第90百分位气温30.5°C有较大的RR值,均在滞后第4 d达到最大,RR值分别为1.0584和1.0710,具有统计学意义。

摘要： 目的分析以家庭为中心模式(FCC)的护理干预对学龄期手足口病(HFMD)患儿康复及护理工作满意度的影响。方法选取2017年9月~2018年8月在本院接受治疗的学龄期手足口病患儿116例,按照入院时间随机分成两组,每组各58例,2017年9月~2018年2月实施常规护理干预的58例患儿为常规组,2018年3月~2018年8月在常规组基础上实施FCC模式的护理干预的58例患儿为FCC组。观察对比两组治疗效果、临床症状消退时间、住院时间、治疗依从性、家属对护理工作满意度及干预前后焦虑情绪(HAMA评分)与生活质量(GQOL-74评分)。结果 FCC组治疗总有效率高于常规组(P<0.05);干预后FCC组皮疹疱疹消退时间、退热时间及住院时间短于常规组(P<0.05);干预后FCC组抗拒行为、面部挣扎、哭闹不止、焦躁不安、语言拒绝5个维度评分小于常规组(P<0.05);干预后GQOL-74评分高于常规组,且HAMA评分小于常规组(P<0.05);干预后FCC组家长疾病知识掌握度高于常规组(P<0.05);干预后FCC组家长对护理工作满意度高于常规组(P<0.05)。结论 FCC模式的护理干预应用于学龄期HFMD患儿,家长对护理工作满意度高,可有效提高家长疾病知识掌握度及生活质量,改善治疗依从性,缓解焦虑情绪,强化治疗效果,缩短康复进程。

摘要： 目的 分析以家庭为中心模式(FCC)的护理干预对学龄期手足口病(HFMD)患儿康复及护理工作满意度的影响.方法 选取2017年9月～2018年8月在本院接受治疗的学龄期手足口病患儿116例,按照入院时间随机分成两组,每组各58例,2017年9月～2018年2月实施常规护理干预的58例患儿为常规组,2018年3月～2018年8月在常规组基础上实施FCC模式的护理干预的58例患儿为FCC组.观察对比两组治疗效果、临床症状消退时间、住院时间、治疗依从性、家属对护理工作满意度及干预前后焦虑情绪(HAMA评分)与生活质量(GQOL-74评分).结果 FCC组治疗总有效率高于常规组(P＜0.05);干预后FCC组皮疹疱疹消退时间、退热时间及住院时间短于常规组(P＜0.05);干预后FCC组抗拒行为、面部挣扎、哭闹不止、焦躁不安、语言拒绝5个维度评分小于常规组(P＜0.05);干预后GQOL-74评分高于常规组,且HAMA评分小于常规组(P＜0.05);干预后FCC组家长疾病知识掌握度高于常规组(P＜ 0.05);干预后FCC组家长对护理工作满意度高于常规组(P＜0.05).结论 FCC模式的护理干预应用于学龄期HFMD患儿,家长对护理工作满意度高,可有效提高家长疾病知识掌握度及生活质量,改善治疗依从性,缓解焦虑情绪,强化治疗效果,缩短康复进程.

摘要： 目的 探讨基于信息、动机、行为技巧(IMB)模型的手足口病(HFMD)幼托儿童健康教育模式.方法 于2016年8月,选择我街道有证的4所幼托机构872名幼托儿童父母作为研究对象,通过发放问卷进行调查,构建并分析IMB模型中预防信息、动机、行为技巧各组分间的关系,并于2016年9月至2017年8月对幼托机构的目标人群进行基于IMB模型的综合健康教育.比较干预前以及干预后幼托儿童家长手足口病预防信息知晓率、正向预防动机比例、预防行为技巧和预防行为的正确率.结果 干预后幼托儿童家长知晓率高于干预前,正向预防动机比例得分高于干预前,预防行为技巧和预防行为的正确率得分高于干预前,差异有统计学意义(P＜0.05);干预后知识来源于新闻媒体、互联网、专业书籍、专家讲座、社区宣传比例均高干预前,差异有统计学意义(P＜0.05).结论 采用基于IMB模型的HFMD健康教育利于提高HFMD信息知晓率,提升预防技巧,并有效落实预防措施.

摘要： 目的 分析不同护理方法在小儿手足口病护理期间的临床效果.方法 选取2016年9月～2017年9月收治的86例手足口病患儿临床资料进行分析,依据护理方法不同,将行常规护理患者作为对照组(43例),行重症早期预警护理患者作为研究组(43例),比较两组实验室指标、病情缓解情况.结果 研究组护理干预后CK (92.01±13.19)U/L、NSE (18.73±4.13)μ goL、CK-MB (25.14±6.46) U/L均低于对照组(P＜0.05);研究组口腔溃疡愈合、疱疹消退以及退热时间均优于对照组(P＜ 0.05).结论 小儿HFMD经重症早期预警护理干预后可显著改善患儿病情,可推广.

摘要： Most of enteroviruses which are frequently found in various waters, have beenrecognized as the common causes of human infection, such as the aseptic meningitis andhand-food-and-mouth disease (HFMD) reported to be prevalent in many regions in China. Toinvestigate the occurrence of the enteroviruses in wastewater and treated wastewater, nested-PCRand the real-time PCR methods were utilized to detect the enteroviruses in three domesticwastewater treatment plants (WWTPs) in Xi’an, China. At the same time, a semi-nested PCRusing groups of specific primers was developed to examine the occurrence of pathogenic virusesof HFMD, i.e. human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), coxsackievirusA10 (CVA10). The result showed that the positive ratios for EV71, CVA16 and CVA10 were only0.06, 0.06 and 0.23, respectively, comparing with the positive ratio of 0.96 for enteroviruses. Theconcentration of enteroviruses in influent and secondary effluent trended to be stable in the rangeof 102-103copies/mL in winter, while it fluctuated in a much wider range in the spring time. Themethodology developed in this study can provide a useful tool for further investigation of theHFMD viruses’ occurrence and their relationship with enteroviruses.

摘要： Most of enteroviruses which are frequently found in various waters, have beenrecognized as the common causes of human infection, such as the aseptic meningitis andhand-food-and-mouth disease (HFMD) reported to be prevalent in many regions in China. Toinvestigate the occurrence of the enteroviruses in wastewater and treated wastewater, nested-PCRand the real-time PCR methods were utilized to detect the enteroviruses in three domesticwastewater treatment plants (WWTPs) in Xi’an, China. At the same time, a semi-nested PCRusing groups of specific primers was developed to examine the occurrence of pathogenic virusesof HFMD, i.e. human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), coxsackievirusA10 (CVA10). The result showed that the positive ratios for EV71, CVA16 and CVA10 were only0.06, 0.06 and 0.23, respectively, comparing with the positive ratio of 0.96 for enteroviruses. Theconcentration of enteroviruses in influent and secondary effluent trended to be stable in the rangeof 102-103copies/mL in winter, while it fluctuated in a much wider range in the spring time. Themethodology developed in this study can provide a useful tool for further investigation of theHFMD viruses’ occurrence and their relationship with enteroviruses.

摘要： Most of enteroviruses which are frequently found in various waters, have beenrecognized as the common causes of human infection, such as the aseptic meningitis andhand-food-and-mouth disease (HFMD) reported to be prevalent in many regions in China. Toinvestigate the occurrence of the enteroviruses in wastewater and treated wastewater, nested-PCRand the real-time PCR methods were utilized to detect the enteroviruses in three domesticwastewater treatment plants (WWTPs) in Xi’an, China. At the same time, a semi-nested PCRusing groups of specific primers was developed to examine the occurrence of pathogenic virusesof HFMD, i.e. human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), coxsackievirusA10 (CVA10). The result showed that the positive ratios for EV71, CVA16 and CVA10 were only0.06, 0.06 and 0.23, respectively, comparing with the positive ratio of 0.96 for enteroviruses. Theconcentration of enteroviruses in influent and secondary effluent trended to be stable in the rangeof 102-103copies/mL in winter, while it fluctuated in a much wider range in the spring time. Themethodology developed in this study can provide a useful tool for further investigation of theHFMD viruses’ occurrence and their relationship with enteroviruses.

摘要： Most of enteroviruses which are frequently found in various waters, have beenrecognized as the common causes of human infection, such as the aseptic meningitis andhand-food-and-mouth disease (HFMD) reported to be prevalent in many regions in China. Toinvestigate the occurrence of the enteroviruses in wastewater and treated wastewater, nested-PCRand the real-time PCR methods were utilized to detect the enteroviruses in three domesticwastewater treatment plants (WWTPs) in Xi’an, China. At the same time, a semi-nested PCRusing groups of specific primers was developed to examine the occurrence of pathogenic virusesof HFMD, i.e. human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), coxsackievirusA10 (CVA10). The result showed that the positive ratios for EV71, CVA16 and CVA10 were only0.06, 0.06 and 0.23, respectively, comparing with the positive ratio of 0.96 for enteroviruses. Theconcentration of enteroviruses in influent and secondary effluent trended to be stable in the rangeof 102-103copies/mL in winter, while it fluctuated in a much wider range in the spring time. Themethodology developed in this study can provide a useful tool for further investigation of theHFMD viruses’ occurrence and their relationship with enteroviruses.