光学相干断层成像术

光学相干断层成像术的相关文献在2000年到2022年内共计121篇,主要集中在眼科学、临床医学、内科学 等领域,其中期刊论文87篇、会议论文4篇、专利文献333910篇;相关期刊47种,包括中国临床护理、中国老年学杂志、临床眼科杂志等; 相关会议4种,包括2015临床急症经验交流高峰论坛、第六届国际心血管热点论坛暨心脏交叉学科论坛、2008中国光电产业发展论坛等;光学相干断层成像术的相关文献由322位作者贡献,包括俞凌峰、任虎刚、王梅等。

光学相干断层成像术—发文量

期刊论文>

论文:87 占比:0.03%

会议论文>

论文:4 占比:0.00%

专利文献>

论文:333910 占比:99.97%

总计:334001篇

光学相干断层成像术—发文趋势图

光学相干断层成像术

-研究学者

  • 俞凌峰
  • 任虎刚
  • 王梅
  • 葛坚
  • 克劳斯·沃格勒
  • 克劳迪娅·格舍博特
  • 克里斯托夫·德尼茨基
  • 克里斯蒂安·维尔纳
  • 刘嫣芬
  • 姜荔
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 叶洪娜
    • 摘要: 目的:观察分析光学相干断层成像术(OCT)对青光眼早期诊断中的应用价值.方法:选取本院2018年2月 ~2019年10月期间收治的经确诊的早期青光眼患者60例(82眼)为观察组,选取同期进行健康体检者60例(120眼)均视力正常为对照组.两组均行OCT检测,对两组受检者各象限视神经纤维层(RNFL)厚度及视盘参数进行对比.结果:观察组各RNFL厚度明显为小于对照组,两组对比差异明显(P0.05),观察组CA、CV、C/D、水平C/D和垂直C/D值明显高于对照组(P0.05).结论:通过OCT检测可以对早期青光患者诊断具有十分重要的价值,可以直观、精确的观察视神经病变的微观层面,观察RNFL厚度与视盘参数的变化,可广泛应用.
    • 戈严
    • 摘要: · AIM:To investigate the retinal nerve fiber layer thickness (RNFL) in normal subjects and primary open angle glaucoma (POAG) patients by optical coherence tomography (OCT),and to provide a theoretical basis for the diagnosis of POAG.· METHODS:Totally 100 patients (123 eyes) with POAG treated in our hospital from November 2014 to November 2017 were selected as the observation group,and 50 cases (100 eyes) matched with age and sex were selected as the control group.Patients with POAG were divided into the early group (36 cases,44 eyes),the advanced group (40 cases,50 eyes) and the late group (24 cases,29 eyes) according to the mean defect(MD).The average RNFL and the MD of the whole visual field,temporal visual field,nasal visual field,inferior visual field,and upper visual field were measured by OCT and automatic perimetry respectively,then their corrections were analyzed.· RESULTS:The average RNFL of the whole visual field,temporal visual field,nasal visual field,inferior visual field,and superior visual field of the observation group were significantly lower than those of the control group,the difference was statistically significant (P<0.001).The MD of the whole visual field,temporal visual field,nasal visual field,inferior visual field,and superior visual field of the observation group were significantly higher than those of the control group,with a statistically significant difference (P<0.001).The mean RNFL of the early group,the advanced group and the late group were thinned successively,paired comparison showed a statistically significant difference (P< 0.001).The MD of the early group,the advanced group and the late group increased successively,paired comparison showed a statistically significant difference (P<0.001).The average RNFL of the whole visual field,temporal visual field,nasal visual field,inferior visual field,and superior visual field were negatively correlated with those fields of the MD (r =-0.675,-0.667,-0.560,-0.711,-0.660;all P<0.001).· CONCLUSION:OCT examination shows that the RNFL of POAG patients is thinner than that of the normal people,and the RNFL becomes thinner with the progression of the disease.And it has a close relationship with MD.%目的:采用光学相干断层成像术(optical coherence tomography,OCT)测量正常人与原发性开角型青光眼(primary open angle glaucoma,POAG)视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度,为POAG的诊断提供理论依据.方法:本组观察对象为2014-11/2017-11于我院就诊的POAG患者100例123眼,设为观察组,选择年龄、性别配对的正常体检人群50例100眼,设为对照组,根据视野平均缺损(mean defect,MD)将POAG患者分为早期组36例44眼、进展期组40例50眼与晚期组24例29眼;采用OCT测量视盘全周、颞侧、鼻侧、下方、上方平均RNFL厚度,各象限MD采用全自动视野计测量,并进行相关性分析.结果:观察组视盘全周、颞侧、鼻侧、下方、上方平均RNFL厚度均显著低于对照组,差异具有统计学意义(P<0.001);观察组视盘全周、颞侧、鼻侧、下方、上方MD均显著高于对照组,差异具有统计学意义(P<0.001);早期组、进展期组与晚期组平均RNFL厚度依次变薄,两两比较差异具有统计学意义(P<0.001),早期组、进展期组与晚期组MD依次变增加,两两比较差异具有统计学意义(P<0.001);视盘全周、颞侧、鼻侧、下方、上方平均RNFL厚度与MD均呈负相关(r=-0.675、-0.667、-0.560、-0.711、-0.660,均P<0.001).结论:OCT检查显示POAG患者RNFL厚度较正常人群明显变薄,且随着病情进展RNFL厚度越薄,且与患眼MD有密切联系.
    • 廖伟; 张玉明; 黄菊; 钟旭
    • 摘要: 目的 探讨选择性激光小梁成形术(SLT)治疗早期药物控制不佳的早发型房角后退性青光眼的临床疗效.方法 对26例(26眼)早期药物控制不佳的早发型房角后退性青光眼患者进行SLT治疗.记录患者术前、术后1 d、1周、1个月、3个月、6个月的眼压;于术前及术后6个月行光学相干断层成像检查视盘周围鼻侧、颞侧、上方、下方的视网膜神经纤维层(RNFC)厚度,行验光检查记录矫正视力;于术前及术后1个月、3个月、6个月检查视野平均缺损(MD);记录术后1周内并发症发生情况.结果 患者术后1 d、1周、1个月、3个月、6个月眼压均低于术前(P0.05);术前与术后1个月、3个月、6个月的视野MD比较,差异无统计学意义(P>0.05);术后1周无角膜灼伤、前房出血和严重前房反应发生.结论 SLT治疗早期药物控制不佳的早发型房角后退性青光眼具有良好的降眼压效果,术后反应轻,安全性好.
    • 周东波
    • 摘要: 目的:探讨光学相干断层成像术(OCT)对青光眼诊断的应用.方法:选取2016年1月—2017年12月期间收治的青光眼患者30例42眼为观察组,同时对照组选取30例60眼视力正常体检者.对两组患者均行OCT检测,对比两组视网膜神经纤维层(RNFL)厚度及视盘参数进行分析.结果:对照组上方、下方、颞侧、鼻侧RNFL厚度明显高于观察组差异具有统计学意义(P<0.05);视盘参数除视盘面积无明显变化,其它参数均较对照组显著增加(P<0.05).结论:光学相干断层成像术(OCT)检查有助于青光眼诊断,其RNFL厚度与视盘参数改变情况是早期诊断青光眼的敏感指标,OCT是对青光眼诊断有效的应用.
    • 李博; 章剑; 徐兴琛; 叶小桂; 方晶
    • 摘要: Objective:To study the clinical application value of optical coherence tomography(OCT)in the measurement of retinal nerve fiber layer(RNFL)thickness in myopia.Methods:73 patients(138 eyes)with myopia who were treated in the hospital from January 2016 to May 2016 were included in this study,according to the condition of myopia,the patients were divided into low myopia group(-0.30~-3.00D)of 26 cases(48 eyes),moderate myopia group(-3.01~-6.00D)of 24 cases(47 eyes)high myopia group(>-6.00D)of 23 cases(43eyes),selected 25 cases of healthy volunteers with normal eyes (45 eyes)as control group over the same period in hospital,RNFL thickness,refraction and axial length of different quadrant of each group were compared,analyzed the correlation between theRNFL thickness of each quadrant of myopia and the refractive index and the axial length of the eyes.Results:RNFL thickness of in the upper quadrant,lower quadrant and the nasal quadrant of the high myopia group were significantly lower than those of the control group and the moderate myopia group,which in lower quadrant and nasal quadrant of the moderate myopia group were significantly lower than that of the control group,and that in nasal quadrant of the low myopia group was significantly lower than that of the control group,the differences were statistically significant (P<0.05).The refractive degree and axial length of the myopia group were significantly higher than control group,and the high myopia group were significantly higher than moderate myopia group and the low myopia group,the moderate myopia group were significantly higher than low myopia group,the differences were statistically significant(P<0.05).According to the correlation analysis of the Pearson method,the RNFL thickness in upper,lower and nasal quadrant of the myopia patients were negatively correlated with the refractive degree and the axial length of the eyes.Conclusion:Using OCT technique to detect the RNFL thickness of myopia,we should consider the influence of refraction and axial length of the eye,and make a comprehensive analysis to get the best value.%目的:研究光学相干断层成像术(OCT)在近视眼视网膜神经纤维层(RNFL)厚度测量中的应用价值.方法:选择2016年1月到2016年5月在医院就诊的近视患者73例(138眼)纳入此次研究,根据近视情况将患者分为低度近视组(-0.30D~-3.00D)共26例(48眼)、中度近视组(-3.01~-6.00D)共24例(47眼)及高度近视组(>-6.00D)共23例(43眼).另选同期在医院体检(视力正常)的健康志愿者25例(45眼)作为对照组,对比各组不同象限的RNFL厚度,屈光度及眼轴长度,分析近视眼各象限的RNFL厚度与患者屈光度和眼轴长度的相关性.结果:高度近视组的上方象限、下方象限以及鼻侧象限的RNFL厚度均明显低于对照组及中度近视组,中度近视组的下方象限及鼻侧象限的RNFL厚度均明显低于对照组,低度近视组鼻侧象限的RNFL厚度明显低于对照组,差异均有统计学意义(均P<0.05).近视组的屈光度及眼轴长度均明显大于对照组,且高度近视组均明显大于中度近视组与低度近视组,中度近视组均明显大于低度近视组,差异均有统计学意义(均P<0.05).根据Pearson法分析相关性可知,近视眼患者上象限、下象限、鼻侧象限的RNFL厚度与其屈光度及眼轴长度均呈负相关.结论:利用OCT技术检测近视眼RNFL厚度时,应考虑屈光度及眼轴长度可能造成的影响,综合进行分析判断,以获得最佳检测数值.
    • 陈吉利; 曹婷怡; 许斐平; 王莎莎; 郑策
    • 摘要: Objective To evaluate low vision in age-related cataract eyes after phacoemulsification (Phaco) using optical coherence tomography (OCT).Methods In this prospective study, we consecutively recruited 72 low vision underwent uncomplicated phacoemulsification.Post-operative visits were performed at 1 month.Best corrective visual acuity (BCVA) was measured and OCT was used to evaluate the fundus.Results The mean age was 78.2 years.The ratio of low vision 1 month post operation was 5.1%.The main finding of OCT evaluation were degenerative myopia, age-related macular degeneration, diabetic retinopathy, macular oedema, epiretinal membrane, retinoschisis, macular hole,retinitis pigmentosa.Logistic regression shows the age was risk factor to cause low vision after surgery.Conclusions In this study, OCT shows great advantage in evaluating retinal disease after Phaco surgery.%目的 运用相干光断层扫描术(OCT)研究无手术并发症的白内障患者在行白内障超声乳化摘除联合人工晶状体植入术后低视力的临床情况.方法 前瞻性临床研究.共连续纳入2014年4月至2016年4月于上海市静安区市北医院白内障超声乳化摘除联合人工晶状体植入术,术中未发生手术并发症,术后1个月的最佳矫正视力<0.3的患者72例(72只眼),于术后1个月进行随访,记录最佳矫正视力(BCVA),并于术后1个月行OCT检查.结果 入选患者的平均年龄为78.2岁.患者术后1个月BCVA小于0. 3者占5.1%.OCT检查提示,导致患者术后低视力的原因有高度近视性脉络膜视网膜病变、老年性黄斑变性、糖尿病性视网膜病变、黄斑水肿、黄斑前膜、视网膜劈裂症、黄斑孔、视网膜色素变性.Logistic 回归模型提示患者年龄是照成术后1个月低视力的危险因素.结论 在本研究中,术后1个月OCT检查有助于了解患者术后低视力的原发病.
    • 熊飞; 姚燕; 姜宏钧; 郝晓琳; 叶秀玲
    • 摘要: 目的 探究在低、中信号强度条件下光学相干断层成像术(OCT)检测视网膜神经纤维层厚度(RNFL)结果的区别.方法 选择眼底像清晰、无明显眼底疾病且光学相干断层扫描图像满意的46~75岁人群400眼,根据不同年龄及不同信号强度分组.应用OCT检测全周和各象限RNFL的厚度.结果 有满意OCT图像眼中,信号强度达到4/10和7/10以上的比例分别为27%和1.5%.低、中信号强度下RNFL厚度最大值在上、下方,且以下方为最厚,而较薄区域为鼻颞侧.低、中信号强度下RNFL厚度各方向及平均厚度差异无统计学意义.结论 低、中信号强度下检测到RNFL结果是可信的.%Objective To investigate the difference of retinal nerve fiber layer thickness(RNFL)in opti-cal coherence tomography(OCT)under low and moderate signal strength. Methods Four hundred eyes of people aged 46~75 with clear fundus image,no obvious fundus diseases,and satisfactory optical coherence tomography were classified according to their ages and signal strength. The peripapillary and 4 quadrants of RNFL were detect-ed with OCT. Results In satisfactory OCT images ,the signal strength that reached 4/10 and 7/10 was 1.5% and 27% respectively. Under low and moderate signal strength ,the maximum thickness of RNFL was at the superior and inferior,and the minimum thickness of RNFL was at the nasal and temporal. There were no significant differ-ences in RNFL thickness under low or moderate signal strength. Conclusion RNFL results are reliable under low and moderate signal strength.
    • 刘健; 徐洁慧; 楼继先; 汪怿; 曹永葆
    • 摘要: 目的 观察糖尿患者白内障超声乳化吸除联合人工晶状体植入术前后黄斑部形态的变化,探讨影响术后最佳矫正视力(BCVA)的相关因素.方法 选择行白内障超声乳化吸除联合人工晶体植入术患者58例(60眼),其中糖尿病组患者29例(31眼),非糖尿病组患者29例(29眼).利用光学相干断层成像术(OCT)测量患者术前与术后不同时间点黄斑各亚区的视网膜厚度值,观察两组黄斑部视网膜厚度变化并探讨其影响因素;将患者术后1个月时logMAR BCVA与患者年龄、性别、糖尿病病程、黄斑部视网膜厚度及变化、高血压病史、HbA1c、高脂血症史及吸烟史作相关性分析,探讨影响患者术后logMAR BCVA的相关因素.结果 糖尿病组与非糖尿病组均在术后1个月时黄斑中心区厚度(CST)的改变量达到最大,之后逐渐缩小.两组术前及术后1个月时CST均与患者的糖尿病病程呈正相关(术前:r=0.53,P<0.01;术后1个月:r=0.69,P<0.05).术后1个月时logMAR BCVA与糖尿病病程(r=0.47,P<0.01)、HbA1c(r=0.38,P<0.01)、术前CST(r=0.61,P<0.01)及吸烟史(r=0.28,P<0.05)相关.通过多元线性回归,确定术前CST为术后logMAR BCVA的独立危险因素(P<0.05).结论 糖尿病患者白内障超声乳化术后1个月时CST改变量达到最大;术前CST与糖尿病病程相关,并影响术后BCVA.%Objective To observe the macular morphology changes before and after phacoemulsification and IOL implantation in diabetic patients by spectral-domain optical coherence tomography (SD-OCT).Methods Fifty eight patients (60 eyes) received phacoemulsification and IOL implantation for cataract,including 29 diabetics (31 eyes) and 29 non-diabetics(29 eyes).Macular SD-OCT scans were performed on all patients before and 1 month after operation.The changes of macular and related influence factors,including age,sex,smoking history,hypertension,hyperlipidemia,HbA1c and diabetes were analyzed.Results The most obvious changes of macular thickness in two groups were observed at 1 month after the surgery.The central subfield thickness (CST) was positively correlated with diabetic duration (before surgery:r =0.53,P<0.01,1 month after surgery:r=0.69,P=0.04).The IogMAR best corrected visual acuity (BCVA) 1 month after surgery was positively correlated with diabetic duration(r=0.47,P<0.01),HbA1c(r=0.38,P<0.01),CST before surgery (r=0.61,P<0.01) and smoking history(r=0.28,P<0.05).Multiple regression analysis showed that CST before surgery was independent risk factor of BCVA(P<0.05).Conclusion CST of diabetes patients after phacoemulsification will reach a peak at 1 month after surgery.CST before surgery is correlated with the diabetic duration,which is the independent risk factors of BCVA after operation.
    • 曲申; 林梦真; 荣翱; 牛耘丽; 王震; 史鑫涛
    • 摘要: 目的 观察高度近视患者晶状体超声乳化术后短期内视网膜神经纤维层(RNFL)厚度的变化.方法 2013年9月至2013年12月我院眼科施行晶状体超声乳化联合人工晶状体植入术46例(52只眼),其中单纯年龄相关性白内障24例(27只眼)(A组),高度近视伴白内障22例(25只眼)(B组).于术前,术后1d、1周、1、3及6个月以光学相干断层成像术(OCT)测量视盘周围RNFL的厚度并进行比较.结果 术前A、B两组患者RNFL平均厚度分别为(94.43±9.35)μm及(90.68±10.15) μm,两者差异有统计学意义(t=-3.653,P=0.000);术后1d两组RNFL厚度几乎无变化,分别为(94.32 ±9.15)μm及(91.32±10.06) μm.术后1周其厚度开始增加,至3个月达到最大值,分别为(100.65±10.25) μm及(98.09±7.57) μm,与术前比较两组患者RNFL厚度均有明显增加,差异均有统计学意义(t=-5.384,P=0.000;t=-4.844,P=0.000);至术后6个月,视盘周围RNFL出现变薄的趋势.结论 超声乳化手术可能对高度近视眼的视网膜神经纤维层有一定影响.%Objective To observe the change of retinal nerve fiber layer thickness of high myopia patients in short-term period after phacoemulsification.Methods Fifty-two eyes of 46 patients treated by phacoemulsification and IOL implantation from September 2013 to December 2013 in Tongji Hospital were enrolled in the study.The patients were divided into two groups,age related cataract group (group A) with 27 eyes of 24 cases and cataract combined with high myopia group (group B) with 25 eyes of 22 cases.The thickness of retinal nerve fiber layer (RNFL) in all cases were measured with optical coherence tomography (OCT),and the changes of RNFL thickness on 1 d,1 week,1 month,3 months and 6 months after surgery were compared with preoperative thickness.Results Before surgery,the mean thickness of RNFL was (94.43 ±9.35)μm in group A,compared with (90.68 ± 10.15) μm in group B.There was statistical difference in RNFL thickness between two groups (t =-3.653,P <0.001).At 1st postoperative day,there was no statistical significant change of the RNFL thickness in both groups (94.32 ±9.15 μm v.s.91.32 ± 10.06 μm).From the first postoperative week,the RNFL thickness began to thickening,the values raised to maximum of (100.65 ± 10.25) μm and (98.09 ± 7.57) μm in two groups respectively.There was statistical difference in the change of RNFL thickness in both groups between preoperatively and 3 months postoperatively (t =-5.384,P =0.000;t =-4.844,P =0.000).To the sixth postoperative month,the RNFL thickness around the optic disc became thinning.Conclusion Phacoemulsification perhaps influence the RNFL of high myopia patients.
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