failure

摘要： Multi-session transarterial chemoembolization(TACE)is usually needed for the treatment of intermediate-stage hepatocellular carcinoma(HCC),but it may not always have a positive influence on prognosis due to high heterogeneity of HCC.To avoid ineffective repeated TACE,the concept of TACE failure/refractoriness has been proposed by several organizations and is being addressed using tyrosine kinase inhibitors.The concept of TACE failure/refractoriness is controversial due to ambiguous definitions and low evidence-based data.To date,only a few studies have examined the rationality concerning the definition of TACE failure/refractoriness,although the concept has been introduced and applied in many TACE-related clinical trials.This review focuses on some of the issues related to different versions of TACE failure/refractoriness,the rationality of related definitions,and the feasibility of continuing TACE after so-called failure/refractoriness based on published evidence.A suggestion to re-define TAEC failure/refractoriness is also put forward.

摘要： Introduction: Cataract surgery has undergone many changes with the size of incision progressively decreasing over time with an incision of 12.0 mm for intracapsular cataract extraction to 2.2 - 2.8 mm in phacoemulsification. However, phacoemulsification due to high cost and equipment maintenance cannot be employed widely in developing countries. The phacoalternative or Manual small-incision cataract surgery (MSICS) offers similar advantages with the merits of wider applicability, less time consuming, a shorter learning curve, and lower cost. Haven’t not being without complications like any other surgery We have identified the factors influencing the outcome of phacoalternative cataract surgery in order to improve our quality of care for our patients suffering from blindness induced by the world’s first leading cause of legal blindness. We have identified the factors influencing the outcome of cataract surgery. Patients and Methods: This was a prospective observational study of the descriptive type lasting six (6) months from March 1 to August 30, 2020 including all patients operated on for cataracts and having lower visual acuity at 3/10. The operating form included demographic data, the patient’s personal ophthalmological history, postoperative visual acuity, per and postoperative complications and the type of pathology involved. The analysis was carried out using epi-info 7.2.0.1 software. Results: During this study period, we collected 61 cases of failure of cataract surgery out of a total of 1182 operated eyes, i.e. a frequency of 5.16%. Women represented more than half of the sample with 74%. Almost all of our patients, i.e. 96.72%, were over the age of 60. Loss of visual acuity was the main complaint in all our patients, i.e. 100% followed by photophobia with 24.4% of cases. Arterial hypertension present in 8.20% of patients was the most common comorbidity in our series followed by diabetes with 4.92%. 18 patients (29.5%) presented early postoperative complications such as corneal edema in 15 patients (24.6%) and hyphema in 3 patients (4.9%). Late postoperative complications were dominated by capsular fibrosis encountered in 42.89% of our patients. The causes of failure after cataract surgery were dominated by selection errors which accounted for 36.06% followed by late postoperative complications 34.43%. Conclusion: Like any surgery, cataract surgery can often be marred by various complications often occurring during the intraoperative or postoperative period. These complications in addition to negligence and/or non-deep analysis of certain cases (selection) are often associated with poor functional recovery.

摘要： Low dose rate brachytherapy(LDR)is an accepted,effective treatment with few local side effects,used as monotherapy in patients with low-risk prostate cancer(PC).The aim of this paper is to analyse 245 patients treated with LDR in the Radiation Oncology Department of the Hospital Gómez Ulla,from 2004 to 2016,evaluating the relationship of dosimetric parameters with biochemical and local recurrence as well as genitourinary and gastrointestinal toxicity derived from the technique.The results obtained show a clear relationship between the dose used and biochemical and local failure.

摘要： Purpose–This study aims to propose a vertical coupling dynamic analysis method of vehicle–track–substructure based on forced vibration and use this method to analyze the influence on the dynamic response of track and vehicle caused by local fastener failure.Design/methodology/approach–The track and substructure are decomposed into the rail subsystem and substructure subsystem,in which the rail subsystem is composed of two layers of nodes corresponding to the upper rail and the lower fastener.The rail is treated as a continuous beam with elastic discrete point supports,and spring-damping elements are used to simulate the constraints between rail and fastener.Forced displacement and forced velocity are used to deal with the effect of the substructure on the rail system,while the external load is used to deal with the reverse effect.The fastener failure is simulated with the methods that cancel the forced vibration transmission,namely take no account of the substructure–rail interaction at that position.Findings–The dynamic characteristics of the infrastructure with local diseases can be accurately calculated by using the proposed method.Local fastener failure will slightly affect the vibration of substructure and carbody,but it will significantly intensify the vibration response between wheel and rail.The maximum vertical displacement and the maximum vertical vibration acceleration of rail is 2.94 times and 2.97 times the normal value,respectively,under the train speed of 350 km$h
1.At the same time,the maximum wheel–rail force and wheel load reduction rate increase by 22.0 and 50.2%,respectively,from the normal value.Originality/value–This method can better reveal the local vibration conditions of the rail and easily simulate the influence of various defects on the dynamic response of the coupling system.

摘要： BACKGROUND Transcrestal sinus floor elevation(TSFE)has been widely used in the oral clinic when the residual bone height(RBH)exceeds 5 mm.However,when there is insufficient RBH in the posterior maxilla,two-stage TSFE may be an option.CASE SUMMARY This article introduces the concept of two-stage TSFE.Six patients had osseointegration failure after TSFE.For the first-stage surgery,we restricted the vertical bone augmentation as much as possible.At the second-stage surgery,the increased RBH was 3.28±1.55 mm,which was beneficial for surgery.Five implants functioned successfully on schedule,but one implant failed again during the healing period.A third surgery was performed,and the implant functioned successfully.CONCLUSION When RBH was less than 5 mm,two or more procedures of TSFE might result in a higher RBH.

摘要： "我其实很少说impossible,几乎不太会有人从我的口中听到‘做不到’三个字。"奥美中国广告总裁薄荣蓉(Melinda Po)说。恰如她非常喜欢的保罗·柯艾略(Paulo Coelho)的一本书《牧羊少年的奇幻之旅》(The Alchemist)中所言,"There is only one thing that makes a dream impossible to achieve:the fear of failure."

摘要： Pipeline transportation is an economical, safe, and efficient transportation method for transporting oil, natural gas, mineral slurry, and other fluids.Welding is the most critical construction process in pipeline engineering and is crucial in the safe operation and service of an entire pipeline system.Theoretically, the girth welded joint is the weakest link in a pipeline system.The unevenness of the structure and performance of the joint caused by welding frequently results in the failure of the welded joint before the failure of the base material of the pipe body, causing the pipeline to leak or even break.For steel pipes used in an acidic corrosive medium environment, the integration of the corrosive medium and mechanical load will accelerate the failure of the welded joint.This article reviews the failure modes of pipeline welded joints in acidic corrosive media, including stress corrosion cracking, hydrogen-induced cracking, and corrosion fracture, and corrosion fatigue considering the diffusion and accumulation of H;at the crack tip.It also reviews service pipelines in acidic corrosive media.The general processing technology of pipe joint engineering critical assessment(ECA) is investigated to provide a reference for the future development of technology in this field.

摘要： BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative residual liver function are not sufficiently accurate.AIM To determine a radiomics model based on preoperative gadoxetic acid-enhanced magnetic resonance imaging for predicting liver failure in cirrhotic patients with HCC after major hepatectomy.METHODS For this retrospective study, a radiomics-based model was developed based on preoperative hepatobiliary phase gadoxetic acid-enhanced magnetic resonance images in 101 patients with HCC between June 2012 and June 2018. Sixty-one radiomic features were extracted from hepatobiliary phase images and selected by the least absolute shrinkage and selection operator method to construct a radiomics signature. A clinical prediction model, and radiomics-based model incorporating significant clinical indexes and radiomics signature were built using multivariable logistic regression analysis. The integrated radiomics-based model was presented as a radiomics nomogram. The performances of clinical prediction model, radiomics signature, and radiomics-based model for predicting post-operative liver failure were determined using receiver operating characteristics curve, calibration curve, and decision curve analyses.RESULTS Five radiomics features from hepatobiliary phase images were selected to construct the radiomics signature. The clinical prediction model, radiomics signature, and radiomics-based model incorporating indocyanine green clearance rate at 15 min and radiomics signature showed favorable performance for predicting postoperative liver failure(area under the curve: 0.809-0.894). The radiomics-based model achieved the highest performance for predicting liver failure(area under the curve: 0.894;95%CI: 0.823-0.964). The integrated discrimination improvement analysis showed a significant improvement in the accuracy of liver failure prediction when radiomics signature was added to the clinical prediction model(integrated discrimination improvement = 0.117, P =0.002). The calibration curve and an insignificant Hosmer-Lemeshow test statistic(P = 0.841) demonstrated good calibration of the radiomics-based model. The decision curve analysis showed that patients would benefit more from a radiomics-based prediction model than from a clinical prediction model and radiomics signature alone.CONCLUSION A radiomics-based model of preoperative gadoxetic acid–enhanced MRI can be used to predict liver failure in cirrhotic patients with HCC after major hepatectomy.

摘要： Drug induced liver injury(DILI)is a common cause of acute liver injury.Paracetamol,also known as acetaminophen,is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic levels.Hepatotoxicity from paracetamol overdose,whether intentional or nonintentional,is the most common cause of DILI in the United States and remains a global issue.Given the increased prevalence of combination medications in the form of pain relievers and antihistamines,paracetamol can be difficult to identify and remains a significant cause of acute hepatotoxicity,as evidenced by its contribution to over half of all acute liver failure cases in the United States.This is especially concerning given that,when co-ingested with other medications,the rise in serum paracetamol levels may be delayed past the 4-hour post-ingestion mark that is currently used to determine patients that require medical therapy.This review serves to describe the clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol and provide an update on current available knowledge and treatment options.

摘要： BACKGROUND Premature ovarian insufficiency(POI)and premature ovarian failure(POF)have become one of the major problems threatening women of childbearing age.Studies have shown that stem cells transplanted from bone marrow,umbilical cord,peripheral blood and amniotic fluid can migrate and proliferate to the ovary,promote ovarian function repair,increase the number of follicles and granulosa cells at all levels of ovary,improve endocrine function,and can differentiate into oocytes in specific ovarian environment to restore fertility to some extent.AIM To study the ability of human umbilical cord mesenchymal stem cells(hUCMSCs)to repair ovarian injury after chemotherapy.METHODS A total of 110 female BALB/c mice(aged 7-8 wk old)with body masses of 16.0-20.0 g were selected.The mice were fed until 12 wk of age,and cyclophosphamide was administered by intraperitoneal injection for 14 consecutive days to induce premature ovarian failure in mice.Seventy-five mice with estrous cycle disorder were screened and randomly divided into 3 groups according to their body weight:model group,positive control group and hUCMSC group,and each group had 25 mice.Another 25 mice were used as negative controls.The mice in the hUCMSC group were injected with hUCMSCs in the tail vein,and the mice in the positive control group were given an oestradiol valerate solution and a medroxyprogesterone acetate solution in the tail vein.On the 1^st,15^th,30^th,45^th,and 60^th days after intravenous administration,vaginal smears were made to monitor the estrous cycles of the mice.The ovaries were weighed,and pathological sections were made to observe the morphology of the follicles;blood samples were collected to monitor the concentration of sex hormones(oestradiol and follicle-stimulating hormone).RESULTS The estrous cycles of the model group mice were disrupted throughout the experiment.Mice in the hUCMSC group and the positive control group resumed normal estrous cycles.The ovarian weight of the model group mice continued to decline.The ovarian weight of the hUCMSC group mice and the positive control group mice decreased first and then gradually increased,and the ovarian weight of the hUCMSC group mice was heavier than that of the positive control group mice.The difference was statistically significant(P<0.05).Compared with the negative control group,the model group experienced a decrease in oestradiol and an increase in follicle-stimulating hormone,and the difference was statistically significant(P<0.05).Compared with the model group,the hUCMSC and positive control groups experienced a slight increase in oestradiol and a decrease in follicle-stimulating hormone;the difference was statistically significant(P<0.05).The pathological examination revealed that the mouse ovaries from the model group were atrophied,the volume was reduced,the cortical and medullary structures were disordered,the number of follicles at all stages was significantly reduced,the number of atretic follicles increased,the number of primordial follicles and corpus luteum significantly decreased,and the corpus luteum had an irregular shape.Compared with those of the model group,the lesions of the hUCMSC and positive control groups significantly improved.CONCLUSION hUCMSCs can repair ovarian tissue damaged by chemotherapy to a certain extent,can improve the degree of apoptosis in ovarian tissue,and can improve the endocrine function of mouse ovaries.

摘要： 本发明实施例提供了一种辅小区组失败SCG Failure处理方法及装置。所述方法应用于主基站，所述方法包括：检测到终端在辅基站发生SCGFailure，且连续第一预设时间内，所述终端仍未接入所述辅基站的小区；将所述终端加入禁止切换至双连接的禁止名单，删除所述终端的双连接链路。通过强制终端驻留在主基站的小区，限制终端通过双连接切换至辅基站的小区，避免主基站与辅基站之间频繁地进行EN‑DC链路的删建，减少了网络侧的信令开销，避免了无线资源的浪费；同时降低UE侧的压力，节约UE的电量。本发明实施例解决了现有技术中，UE发生SCG Failure，NSA系统会不断地进行EN‑DC链路的删建的问题。

摘要： 本发明公开了一种SCG Failure的处理方法及设备，所述方法包括辅基站SN接收用于指示用户设备UE发生辅小区组失败SCG Failure的第一消息，其中，所述第一消息为主基站MN接收到所述UE上报的SCG Failure之后产生的信息，所述第一消息携带UE在发生SCG Failure时获得的测量结果；所述SN中UE的服务小区根据所述测量结果，确定进行主辅小区PSCELL切换，以使得所述UE接入切换后的目标PSCELL，或者，所述SN根据所述测量结果，确定进行SN切换，以使得所述UE接入切换后的目标SN。

摘要： 本发明实施例提供了一种辅小区组失败SCG Failure处理方法及装置。所述方法应用于主基站，所述方法包括：检测到终端在辅基站发生SCGFailure，且连续第一预设时间内，所述终端仍未接入所述辅基站的小区；将所述终端加入禁止切换至双连接的禁止名单，删除所述终端的双连接链路。通过强制终端驻留在主基站的小区，限制终端通过双连接切换至辅基站的小区，避免主基站与辅基站之间频繁地进行EN‑DC链路的删建，减少了网络侧的信令开销，避免了无线资源的浪费；同时降低UE侧的压力，节约UE的电量。本发明实施例解决了现有技术中，UE发生SCG Failure，NSA系统会不断地进行EN‑DC链路的删建的问题。

摘要： 本发明公开了一种SCG Failure的处理方法及设备，所述方法包括辅基站SN接收用于指示用户设备UE发生辅小区组失败SCG Failure的第一消息，其中，所述第一消息为主基站MN接收到所述UE上报的SCG Failure之后产生的信息，所述第一消息携带UE在发生SCG Failure时获得的测量结果；所述SN中UE的服务小区根据所述测量结果，确定进行主辅小区PSCELL切换，以使得所述UE接入切换后的目标PSCELL，或者，所述SN根据所述测量结果，确定进行SN切换，以使得所述UE接入切换后的目标SN。