exercise

摘要： BACKGROUND Annually,there are an estimated 1187000 new patients worldwide diagnosed with haematological malignancies.Effective strategies are needed to alleviate side effects and prevent the physical and psychosocial degeneration of patients in active treatment for haematological malignancies.AIM To explore the effects of physical exercise on quality of life(Qo L)of patients with haematological malignancies and thrombocytopenia.METHODS Cochrane Library,Pub Med and Embase were searched for all relevant articles reporting randomized controlled trials(RCTs)that were published up to 31 July 2021.Two authors independently selected articles in accordance with the inclusion criteria,evaluated their quality,and collected information.Any controversy was resolved through discussion with a third senior author.The PRISMA 2009 checklist was followed.RESULTS Seven RCTs were selected in the systematic review and three were included in the final meta-analysis.There were significant differences in Qo L between physical exercise groups[mean score difference=8.81;95%confidence interval(CI):1.81-15.81,P=0.01],especially in emotional functioning(mean score difference=12.34;95%CI:4.64-20.04,P=0.002)and pain(mean score difference=–12.77;95%CI:-3.91 to-21.63,P=0.005).CONCLUSION Physical exercise has clinical effects on Qo L and improves emotional function and pain indices of patients with haematological malignancies and thrombocytopenia.

摘要： Eccentric exercise has been associated with an increase in serial sarcomere number in some studies,1 but not in others.2 Similarly,increasing excursion of muscles resulted in sarcomerogenesis in some studies using growing animals,3 but not in others using skeletally mature animals.4 However,chronic elongation and chronic shortening appears to be a strong regulator of sarcomere number increase5,6 and decrease,5,7 respectively,in animal models.Despite an abundance of research on the regulation of sarcomerogenesis under a variety of conditions,the mechanisms underlying in series sarcomere number adaptations in skeletal muscles remain a puzzle,especially in non-invasive human studies where measurements of sarcomerogenesis following interventions have not been possible to date.

摘要： BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is associated with a sedentary lifestyle and depressive symptoms.It is also well established that physical inactivity and depressive symptoms are related.However,an investigation of the interaction between all of these factors in NAFLD has not been previously conducted.AIM To investigate the interrelationship between physical inactivity and depressive symptoms in individuals with NAFLD.METHODS Data from the Rancho Bernardo Study of Healthy Aging were utilized.589 individuals were included in the analyses(43.1%male;95.8%non-Hispanic white;aged 60.0±7.0 years).NAFLD was defined by using the hepatic steatosis index,depression using the Beck Depression Inventory,and physical activity by selfreport of number of times per week of strenuous activity.Multivariable generalized linear regression models with Gamma distribution were performed to investigate the proposed relationship.RESULTS About 40%of the sample had evidence of NAFLD,9.3%had evidence of depression,and 29%were physically inactive.Individuals with NAFLD and depression were more likely to be physically inactive(60.7%)compared to individuals with neither NAFLD nor depression(22.9%),individuals with depression without NAFLD(37.0%),and individuals with NAFLD without depression(33.3%).After accounting for various comorbidities(i.e.,age,sex,diabetes,hypertension,obesity),individuals with NAFLD and higher levels of physical activity were at a decreased odds of having depressive symptoms[16.1%reduction(95%confidence interval:-25.6 to-5.4%),P=0.004],which was not observed in those without NAFLD.CONCLUSION Individuals with NAFLD have high levels of physical inactivity,particularly those with depressive symptoms.Because this group is at high risk for poor outcomes,practitioners should screen for the coexistence of depressive symptoms and NAFLD.This group should receive appropriate interventions aimed at increasing both participation and levels of intensity of physical activity.

摘要： No definite consensus has currently been reached regarding the safety and efficacy of low-or high-frequency repetitive transcranial magnetic stimulation in the treatment of post-stroke muscle spasticity.The latest research indicates that when combined with local injections of botulinum toxin type A,it is more effective on post-stroke muscle spasticity than local injections of botulinum toxin type A alone.We designed a prospective,single-center,non-randomized,controlled clinical trial to investigate the safety and effica cy of different frequencies of repetitive transcranial magnetic stimulation combined with local injections of botulinum toxin type A in treating post-stroke lower limb muscle spasticity to determine an optimal therapeutic regimen.This trial will enroll 150 patients with post-stroke muscle spasticity admitted to the Department of Rehabilitation Medicine at the First Affiliated Hos pital of China Medical Unive rsity.All enrolled patients will undergo ro utine rehabilitation training and will be divided into five groups in-30 per group) according to the particular area of cerebral infa rction and treatment methods.G roup A:Patients with massive cerebral infarction will be given local injections of botulinum toxin type A and low-frequency(1 Hz)repetitive transcranial magnetic stimulation on the contralate ral side;G roup B:Patients with non-massive cerebral infarction will be given local injections of botulinum toxin type A and high-frequency(10-20 Hz) re petitive transcranial magnetic stimulation on the affected side;G roup C:Patients with massive/non-massive cerebral infarction will be given local injections of botulinum toxin type A;G roup D:Patients with massive cerebral infarction will be given low-frequency(1 Hz) repetitive transcranial magnetic stimulation on the contralate ral side;and G roup E:Patients with non-massive cerebral infa rction will be given high-frequency(10-20 Hz) repetitive transcranial magnetic stimulation on the affected side.The primary outcome measure of this trial is a modified Ashwo rth scale score from 1 day before treatment to 12 months after treatment.Secondary outcome measures include Fugl-M eyer Assessment of Lower Extremity,Visual Analogue Scale,modified Barthel index,and Berg Balance Scale scores for the same time as specified for primary outcome measures.The safety indicator is the incidence of adverse events at 3-12 months after treatment.We hope to draw a definite conclusion on whether there are diffe rences in the safety and efficacy of low-or high-frequency repetitive transcranial magnetic stimulation combined with botulinum toxin type A injections in the treatment of patients with post-stroke lower limb spasticity under strict grouping and standardized operation,thereby screening out the optimal therapeutic regimen.The study protocol was approved by the Medical Ethics Committee of the First Affiliated Hospital of China Medical University(approval No.[2021] 2021-333-3) on August 19,2021.The trial was registe red with the Chinese Clinical Trial Registry(Registration No.ChiCTR2100052180) on October 21,2021.The protocol version is 1.1.

摘要： Purpose This study aimed to describe the national prevalence of Chinese children and adolescents who met the World Health Organization muscle-strengthening exercise(MSE)recommendations and identify correlates of meeting the MSE recommendations.Methods Cross-sectional data from the 2019 Physical Activity and Fitness in China—The Youth Study,a nationally representative sample of Chinese children and adolescents(n=80,413;mean age=13.7 years;53.9%girls)and their parents,were analyzed.Children and adolescents who reported engaging≥3 days(up to 7 days)of MSE per week were classified as meeting the MSE recommendations.MSE,demographics,lifestyle behaviors(sport participation,moderate-to-vigorous physical activity,screen time,and sleep duration),exercise intention,peer and parental support,and parental MSE participation were assessed through self-reports.Logistic regression models were used to determine the correlates of meeting the MSE recommendations.The analyses were completed in 2020.Results Overall,39.3%of children and adolescents met the MSE recommendations.Girls,10th-12th graders,minorities,those from lower income households and those from families with lower parental education were less likely to meet the MSE recommendations.Children and adolescents who were proficient in≥2 sports were more likely to meet the MSE recommendations(adjusted odds ratio(aOR)=1.44,95%confidence interval(95%CI):1.26-1.65),as were those with more moderate-to-vigorous physical activity(aOR=1.57,95%CI:1.53-1.61).Additionally,children and adolescents with high exercise intention(aOR=1.60,95%CI:1.51-1.69),those whose parents met the adult MSE recommendations(aOR=1.46,95%CI:1.40-1.52),and those who received high peer(aOR=1.27,95%CI:1.20-1.34)and parental support(aOR=1.07,95%CI:1.04-1.12)were more likely to meet the MSE recommendations.Conclusion Less than two-fifths of Chinese children and adolescents met the World Health Organization MSE recommendations.The correlates identified in our study can help inform the development of school and community based strategies and policies to enhance participation in MSE and improve muscular fitness of all Chinese children and adolescents.

摘要： Exercise-induced changes of the microbiome in inflammatory bowel diseases(IBD)is a promising field of research with the potential for personalized exercise regimes as a promising therapeutic adjunct for restoring gut dysbiosis and additionally for regulating immunometabolic pathways in the management of IBD patients.Structured exercise programmes in IBD patients of at least of 12 wk duration are more likely to result in disease-altering changes in the gut microbiome and to harness potential anti-inflammatory effects through these changes along with immunometabolic pathways.

摘要： The magnitude of diabetes mellitus(DM)has increased in recent decades,where the number of cases and the proportion of the disease have been gradually increasing over the past few decades.The chronic complications of DM affect many organ systems and account for the majority of morbidity and mortality associated with the disease.The prevalence of type 1 DM(T1DM)is increasing globally,and it has a very significant burden on countries and at an individual level.T1DM is a chronic illness that requires ongoing medical care and patient self-management to prevent complications.This study aims to discuss the health benefits of physical activity(PA)in T1DM patients.The present review article was performed following a comprehensive literature search.The search was conducted using the following electronic databases:“Cochrane Library”,Web of Science,PubMed,HINARI,EMBASE,Google for grey literature,Scopus,African journals Online,and Google Scholar for articles published up to June 21,2021.The present review focused on the effects of PA on many outcomes such as blood glucose(BG)control,physical fitness,endothelial function,insulin sensitivity,well-being,the body defense system,blood lipid profile,insulin resistance,cardiovascular diseases(CVDs),insulin requirements,blood pressure(BP),and mortality.It was found that many studies recommended the use of PA for the effective management of T1DM.PA is a component of comprehensive lifestyle modifications,which is a significant approach for the management of T1DM.It provides several health benefits,such as improving BG control,physical fitness,endothelial function,insulin sensitivity,well-being,and the body defense system.Besides this,it reduces the blood lipid profile,insulin resistance,CVDs,insulin requirements,BP,and mortality.Overall,PA has significant and essential protective effects against the health risks associated with T1DM.Even though PA has several health benefits for patients with T1DM,these patients are not well engaged in PA due to barriers such as a fear of exercise-induced hypoglycemia in particular.However,several effective strategies have been identified to control exercise-induced hypoglycemia in these patients.Finally,the present review concludes that PA should be recommended for the management of patients with T1DM due to its significant health benefits and protective effects against associated health risks. Italso provides suggestions for the future direction of research in this field.

摘要： Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer survivors.Methods:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer survivors.Standardized mean differences(SMDs)were calculated to assess effects on physical activity and health-related outcomes.Subgroup analyses were conducted to assess whether the effects differed by interventions and cancer characteristics.Risk of bias was assessed using the Cochrane risk of bias tool.Results:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 year.Most trials(n=25,71%)involved pedometer-based physical activity interventions.Seven(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily steps.Compared to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with cancer.Identifying how these devices can be implemented for longer-term use with other intervention components remains an area for future research.

摘要： Background:Accumulating evidence suggests that sports participation promotes the development of inhibitory control,but the influences of the sports category and inhibition type still remain unclear.The categorization of sports based on the open-skill(externally paced)and closed-skill(self-paced)continuum allows for the integration of the environment as a factor contributing to sports-related benefits for inhibitory control.Methods:Cross-sectional data from different studies were combined(n=184)to examine the association between open-and closed-skill sports and cognitive control processes related to interference control and response inhibition.Participants(aged 9-14 years)filled in 7-day physical activity recall protocols and completed a Stroop Color-Word or a Go/NoGo task.The N200,N450,and P300 components of event-related potentials elicited by these tasks were recorded using electroencephalography.Results:Partial correlations supported the belief that time spent in open-skill sports was related to higher performance on inhibition trials.Additionally,path analyses revealed an association between this sports type and a greater negativity in the N200 and N450 amplitudes in both the full sample and group-level analyses.In contrast,no relation was found between sports type and P300 amplitude.Conclusion:The findings suggest that only the engagement in open-skill sports is associated with more effective conflict monitoring and higher performance on tasks demanding inhibitory control.

摘要： Background:Exercise is a promising nonpharmacological therapy for cognitive dysfunction,but it is unclear which type of exercise is most effective.The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment(MCI)or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.Methods:We searched PubMed,Web of Science,Embase,Cochrane Central Register of Controlled Trials,SPORTDiscus,and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia.Primary outcomes included global cognition,executive cognition,and memory cognition.Secondary outcomes included activities of daily living,neuropsychiatric symptoms,and quality of life.Pairwise analyses and network meta-analyses were performed using a random effects model.Results:A total of 73 articles from 71 trials with 5606 participants were included.All types of exercise were effective in increasing or maintaining global cognition,and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition(standard mean difference(SMD)=1.05,95%confidence interval(95%CI):0.56-1.54),executive function(SMD=0.85,95%CI:0.21-1.49),and memory function(SMD=0.32,95%CI:0.01-0.63)in patients with cognitive dysfunction.Subgroup analyses for patients with MCI revealed different effects,and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition(SMD=0.99,95%CI:0.44-1.54)and executive function(SMD=0.72,95%CI:0.06-1.38).However,only resistance exercise showed significant effects on memory function for patients with MCI(SMD=0.35,95%CI:0.01-0.69).Exercise interventions also showed various effects on the secondary outcomes.Conclusion:Resistance exercise has the highest probability of being the optimal exercise type for slowing cognitive declin e in patients withcognitive dysfunction,especially in patients with dementia.Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI.