摘要：
目的 探讨复方玄驹胶囊对弱精症男性不育患者精液质量、精子功能形态及精浆一氧化氮(N0)水平的影响.方法 回顾性分析2015年1月～2016年6月保定市第二中心医院收治的80例弱精症男性不育患者的临床资料,按照治疗方法分为复方玄驹组和常规治疗组,每组各40例,另选择30名精子质量正常的已婚已育男性作为健康对照组进行对比分析.常规治疗组应用抗生素、能量剂及激素类药物治疗,复方玄驹组在常规治疗组基础上给予复方玄驹胶囊治疗.比较治疗前后患者精液质量变化,同时比较三组精子顶体完整性及精浆一氧化氮水平.结果 治疗3个月后,两组患者精子密度均较治疗前明显下降(P＜0.05),但组间差异无统计学意义(P＞0.05),两组患者精子活率及精子活力a级、a+b级百分比均较治疗前明显升高,且复方玄驹组各指标明显高于常规治疗组,差异均有统计学意义(P＜ 0.05或P＜0.01).治疗后,复方玄驹组患者精子顶体完整率较治疗前明显升高(P＜0.01),而常规治疗组变化不明显(P＞ 0.05);复方玄驹组患者精子顶体完整率与健康对照组差异无统计学意义(P＞0.05),且均明显高于常规治疗组,差异均有统计学意义(P＜ 0.05或P＜0.01).治疗后,两组患者精浆NO水平均较治疗前明显降低(P＜ 0.05或P＜ 0.01),复方玄驹组患者精浆NO水平与健康对照组差异无统计学意义(P＞0.05),且均明显低于常规治疗组,差异均有统计学意义(P＜ 0.05或P＜0.01).结论 复方玄驹胶囊能明显提高弱精症男性不育患者精液质量及精子顶体完整率,降低精浆NO水平,对提高弱精症患者疗效具有重要价值,值得临床推广.%Objective To investigate the effect of sperm quality,sperm function form and seminal plasma nitric oxide level of weak sperm disease patients treating with Compound Xuanju Capsules.Methods From January 2015 to June 2016,in the Second Central Hospital of Baoding,the clinical data of 80 weak sperm male infertilitypatients were retrospective analyzed,they were divided into compound Xuanju group and convention treatment group by treatment method,with 40 cases in each group,and 30 normal sperm quality married with children men were selected as healthy control group.The convention treatment group patients were treated with antibiotic,energy agent and hormone drugs,the compound Xuanju group patients were given Compound Xuanju Capsules on the basis of convention treatment group.The sperm quality changes of patients before and after treatment were compared,and the sperm acrosome integrality and seminal plasma nitric oxide level detection of three groups were compared.Results After 3 months treatment,the sperm density of patients in two groups were significantly decreased than before the treatment (P ＜ 0.05),but there was no statistical significance between the two groups (P ＞ 0.05);the live sperm rate and sperm vitality grade a,a+b level percents of patients in two groups were significantly increased than before the treatment,and the indexes of compound Xuanju group were obviously higher than that of convention treatment group,the differences were statistical significance (P ＜ 0.05 or P ＜ 0.01).After the treatment,the sperm acrosome integrality rate of compound Xuanju group significantly increased than before the treatment (P ＜ 0.01),and the changes of the conventional treatment were not obvious (P ＞ 0.05);the sperm acrosome integrality rate had no statistical significance between the compound Xuanju group and healthy control group (P ＞ 0.05),and these were significantly higher than that in the convention treatment group,the differences were statistical significant (P ＜ 0.05 or P ＜ 0.01).After the treatment,the seminal plasma NO levels of patients in two groups were significantly lower than those before the treatment (P ＜ 0.05 or P ＜ 0.01),the seminal plasma NO levels had no statistical significance between compound Xuanju group and healthy control group (P ＞ 0.05),and these were significantly lower than that in the convention treatment group,the differences were statistical significant (P ＜ 0.05 or P ＜ 0.01).Conclusion Compound Xuanju Capsules can obviously improve the sperm quality and the sperm acrosome integrality rate of the weak sperm male infertility patients,reduce the seminal plasma NO levels,and it has important value to improve the curative effect for weak sperm disease patients,it is worth of clinical promotion.
