Al

摘要： Sortilin was discovered in 1997 by Petersen and his colleagues.The single transmembrane receptor was isolated as a 95 kDa membrane glycoprotein by receptor-associated protein affinity chromatography and therefore initially named gp95.The cDNA library screening revealed sequence homology between the luminal segment of gp95/sortilin and the yeast vacuolar sorting protein 10 protein(Vps10p)domain(Petersen et al.,1997).The Vps10p domain was first identified in the Saccharomyces cerevisiae protein Vps10p that directs lysosomal enzymes from the Golgi to the vacuole(Marcusson et al.,1994).

摘要： The choroid plexus(ChP)is a highly vascularized and secretory tissue in each of the brain ventricles that represents the key structure between the blood and the cerebrospinal fluid(CSF).Besides its essential role in CSF production and brain waste clearance pathways,the ChP also contributes to the regulation of central nervous system(CNS)immunosurveillance(Ghersi-Egea et al.,2018).Indeed,the ChP forming the blood-CSF barrier(BCSFB)regulates the entry of immune cells and solute molecules into the brain and vice versa.When antigen-specific,autoreactive immune activation occurs in the periphery,inflammatory cells migrate through the brain barriers towards the CNS(Strominger et al.,2018),initiating neuroinflammatory diseases such as multiple sclerosis(MS).

摘要： Retraction:Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children https://doi.org/10.4103/1673-5374.346552 The Editors of Neural Regeneration Research(NRR)h a s ret ra c te d t h e p u b l i cat i on entitled“Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children”(He et al.,2012;doi:10.3969/j.issn.1673-5374.2012.32.007)following the concerns of duplicate publication according to NRR Policy on Article Retraction(https://journals.lww.com/nrronline/Pages/instructionsforauthors.aspx).

摘要： The sense of smell supports the identification and the safety of food,warns of danger/predators,and plays a key role in mating(Croy and Hummel,2017;Kondo et al.,2020;Tzeng et al.,2021).Via connection to the limbic system,it supports behavioral adaption and emotions and can detect fear,tears,and happiness in the body odor of others(Croy and Hummel,2017;Tzeng et al.,2021).

摘要： Synaptosome:Synapses are the most critical portion of neuron connections,necessary for cellular organization of the brain.Synapse integrity is uttermost important for healthy brain functioning.Any perturbation in the synapse structure and/or function initiates neurological disorders.Synapses are the prime targets that are smashed in almost all neurodegenerative diseases.The vital components of synapse are essential for neurotransmission,synaptic plasticity and overall synapse function.Synapse dysfunctions are well studied in Alzheimer’s disease(AD)and other neurodegenerative diseases(Gowda et al.,2021).The best way to study the synapse dysfunctions in neurological diseases is the biochemical analysis of“synaptosome”.

摘要： In neuroscience research,neuronal models are crucial tools for elucidating the molecular and cellular processes involved in the disorders of the nervous system.Facilitating easily and reproducibly executable studies,in vitro models,such as the SH-SY5Y cell line culture,help us explore the pathophysiological mechanisms of neurodegenerative diseases;they are also essential for the efficient screening of drugs for treating the diseases of the nervous system(Peng et al.,2021;Strother et al.,2021).

摘要： Ketamine,a multimodal dissociative anesthetic,produces powerful analgesia at subanesthetic doses in traumatically injured patients.As ketamine does not induce respiratory depression or hemodynamic instability,the Committee on Tactical Combat Casualty Care for the US military recommends the use of subanesthetic doses of ketamine for acute pain management(Butler et al.,2014).Additionally,ketamine may have immunomodulatory effects after injury at subanesthetic doses,mediating the balance of pro-and anti-inflammatory processes(Loix et al.,2011;De Kock et al.,2013).

摘要： Ischemic retinopathy is a retinal disease caused by ischemic attacks.Ischemia is a common pathologic mechanism in various retinal disorders and diseases such as age-related macular degeneration,diabetic retinopathy,glaucoma,or vascular occlusion(Osborne et al.,2004).Although various murine models have been developed to understand a series of metabolic mechanisms induced by retinal ischemia and further used to test promising therapeutics,effective treatment in ischemic retinopathy has not been clearly suggested.This is associated with the notion that the contributing pathologic metabolic pathways might be enormously complex.

摘要： The P2X4 receptor belongs to the P2X receptor family of trimeric ligand-gated ion channels and was the first member of this family for which a crystal structure was obtained(Kawate et al.,2009).This structure confirmed the trimeric stoichiometry of P2X receptors and subsequent studies from the same group revealed the orthosteric binding site of the natural ligand adenosine 5′-triphosphate(ATP)in a cleft between each adjacent subunit(Hattori and Gouaux,2012).Now synonymous with structural descriptions of P2X receptors,these original studies described the structure of each P2X4 receptor subunit as that resembling a dolphin.

摘要： Hevin/Sparcl1(hereafter referred to as Hevin)is an extracellular matrix protein encoded by the SPARCL1 gene.Recently,it has been revealed that Hevin has various functions,such as synapse formation,neuronal migration,inflammation,and angiogenesis(Gongidi et al.,2004;Naschberger et al.,2016;Singh et al.,2016;Liu et al.,2021).In addition,genome-wide association studies uncovered de novo and familial mutations of the SPARCL1 gene associated with a risk for autism spectrum disorder(ASD)(De Rubeis et al.,2014).However,the relationship between ASD-associated Hevin mutant and cellular phenotype has not been clarified.Recently,we have reported that ASD-associated mutation in Hevin reduces secretion efficiency and induces endoplasmic reticulum(ER)stress caused by structural instability(Taketomi et al.,2022).In this perspective,we discuss the relationship between the molecular functions of Hevin and ASD risk(Figure 1A).Also,we introduce our recent findings that link ASD-associated Hevin mutant to the cellular phenotype of ASD.

摘要： 通过干湿循环加速试验模拟了Al表面沉积沙漠浮土情况下的大气腐蚀过程,利用失重分析、扫描电镜(SEM)和大气腐蚀监测仪(ACM)研究了浮土中可溶性盐对Al的大气腐蚀的影响.结果表明：浮土中的可溶性盐会使发生大气腐蚀的相对湿度范围变宽,随着可溶性盐含量的提高A1的腐蚀不断恶化.在可溶性盐成分中,MgCl2对Al的腐蚀影响最大,Nacl次之,MgSO4和Na2SO4的影响较小.

摘要： 通过干湿循环加速试验模拟了Al表面沉积沙漠浮土情况下的大气腐蚀过程,利用失重分析、扫描电镜(SEM)和大气腐蚀监测仪(ACM)研究了浮土中可溶性盐对Al的大气腐蚀的影响.结果表明：浮土中的可溶性盐会使发生大气腐蚀的相对湿度范围变宽,随着可溶性盐含量的提高A1的腐蚀不断恶化.在可溶性盐成分中,MgCl2对Al的腐蚀影响最大,Nacl次之,MgSO4和Na2SO4的影响较小.

摘要： 通过干湿循环加速试验模拟了Al表面沉积沙漠浮土情况下的大气腐蚀过程,利用失重分析、扫描电镜(SEM)和大气腐蚀监测仪(ACM)研究了浮土中可溶性盐对Al的大气腐蚀的影响.结果表明：浮土中的可溶性盐会使发生大气腐蚀的相对湿度范围变宽,随着可溶性盐含量的提高A1的腐蚀不断恶化.在可溶性盐成分中,MgCl2对Al的腐蚀影响最大,Nacl次之,MgSO4和Na2SO4的影响较小.

摘要： 通过干湿循环加速试验模拟了Al表面沉积沙漠浮土情况下的大气腐蚀过程,利用失重分析、扫描电镜(SEM)和大气腐蚀监测仪(ACM)研究了浮土中可溶性盐对Al的大气腐蚀的影响.结果表明：浮土中的可溶性盐会使发生大气腐蚀的相对湿度范围变宽,随着可溶性盐含量的提高A1的腐蚀不断恶化.在可溶性盐成分中,MgCl2对Al的腐蚀影响最大,Nacl次之,MgSO4和Na2SO4的影响较小.

摘要： 通过干湿循环加速试验模拟了Al表面沉积沙漠浮土情况下的大气腐蚀过程,利用失重分析、扫描电镜(SEM)和大气腐蚀监测仪(ACM)研究了浮土中可溶性盐对Al的大气腐蚀的影响.结果表明：浮土中的可溶性盐会使发生大气腐蚀的相对湿度范围变宽,随着可溶性盐含量的提高A1的腐蚀不断恶化.在可溶性盐成分中,MgCl2对Al的腐蚀影响最大,Nacl次之,MgSO4和Na2SO4的影响较小.

摘要： 提出氟化稀土中的铝、铁杂质元素的一种快速分析方法,采用高氯酸、盐酸分解样品,草酸将稀土沉淀分离,用ICP-AES法测定试液中的Al、Fe,加标回收率达98-103﹪,相对标准偏差<2.0﹪,此方法分析简单快速、结果准确可靠。

摘要： 提出氟化稀土中的铝、铁杂质元素的一种快速分析方法,采用高氯酸、盐酸分解样品,草酸将稀土沉淀分离,用ICP-AES法测定试液中的Al、Fe,加标回收率达98-103﹪,相对标准偏差<2.0﹪,此方法分析简单快速、结果准确可靠。

摘要： 提出氟化稀土中的铝、铁杂质元素的一种快速分析方法,采用高氯酸、盐酸分解样品,草酸将稀土沉淀分离,用ICP-AES法测定试液中的Al、Fe,加标回收率达98-103﹪,相对标准偏差<2.0﹪,此方法分析简单快速、结果准确可靠。

摘要： 提出氟化稀土中的铝、铁杂质元素的一种快速分析方法,采用高氯酸、盐酸分解样品,草酸将稀土沉淀分离,用ICP-AES法测定试液中的Al、Fe,加标回收率达98-103﹪,相对标准偏差<2.0﹪,此方法分析简单快速、结果准确可靠。

摘要： 提出氟化稀土中的铝、铁杂质元素的一种快速分析方法,采用高氯酸、盐酸分解样品,草酸将稀土沉淀分离,用ICP-AES法测定试液中的Al、Fe,加标回收率达98-103﹪,相对标准偏差<2.0﹪,此方法分析简单快速、结果准确可靠。

摘要： 提供具有高导电率和良好的加工性、且具有高强度的Al－Mg－Si系合金材料。将具有纤维组织的Al－Mg－Si系合金材料的抗拉强度设为280MPa以上，并将导电率设为54％IACS以上。

摘要： 本发明Al3Sc‑Al3Zr/Al复合材料孕育剂的制备方法，涉及铝基合金，步骤是：依据目标合金中各组分元素的质量百分比为：Sc 1.00％～2.00％、Zr 1.00％～2.00％，其余为Al进行原料配制；块状Al‑Sc‑Zr中间合金的原位合成制备和超声处理；快速凝固技术制得薄带状Al3Sc‑Al3Zr/Al复合材料孕育剂产品。本发明方法用添加廉价Zr元素替代一部分价格高昂的Sc元素，降低了产品成本，克服了现有技术中形核颗粒不能在基体上弥散分布或弥散程度还不理想、颗粒在熔体中的聚集沉淀和颗粒尺寸大，Al‑Sc合金中Al3Sc颗粒尺寸过大和数量较少缺陷。

摘要： 本发明提供一种水反应性Al复合材料，在Al中，以Al基准计，添加2.0～3.5wt％的In、0.2～0.5wt％的Si、0.13～0.25wt％的Ti而成，其在水分存在下的气氛中进行反应溶解而得到。使用该材料制造的水反应性Al喷镀膜及该Al喷镀膜的制造方法以及在表面具备该Al喷镀膜的成膜室用构成构件。

摘要： 本发明提供一种技术，在薄膜晶体管基板、反射膜、反射阳极电极、触摸屏传感器等的制造工序中，能够有效防止氯化钠溶液的浸渍下的Al合金表面的腐蚀和针孔腐蚀(黑点)等的腐蚀，耐腐蚀性优异，而且能够防止小丘的生成且耐热性也优异的Al合金膜。本发明的Al合金膜，是用于配线膜或反射膜的Al合金膜，其中，含有Ta和/或Ti：0.01～0.5原子％、稀土类元素：0.05～2.0原子％。

摘要： 本发明提供一种向熔融锌锅供给Zn-Al合金的方法，其是向热浸镀锌生产线中的收容有熔融锌液的熔融锌锅供给Zn-Al合金的方法，其中，具有从设在管状的插入导向器的下部的供给部供给所述Zn-Al合金的供给工序；所述供给部被浸渍在所述熔融锌锅在钢板的行走方向上的下游侧的内壁与设在所述熔融锌液中的前支承辊之间，且在距所述前支承辊的下端±400mm以内的深度；所述插入导向器的内部通过不活泼气体而被加压，防止所述熔融锌液侵入所述插入导向器的所述内部。

摘要： 一种Al4O4C结合Al-Al2O3复合无碳滑板及制备方法，属于耐火材料领域。该滑板原料组成为60-85%的刚玉、5-20%的活性氧化铝、2-20%的金属Al，外加上述原料总量2-6%的酚醛树脂为结合剂。生产时按配比称取各种原料，混合均匀，经混炼得到泥料，然后压制成型，在200±10°C下干燥5-10h，然后在1200-1700°C下埋炭条件下烧成。该产品具有金属-非金属结合的结构，有优良的物理性能指标：显气孔率3-10%、体积密度3.1-3.4g/cm3、常温耐压强度150-500MPa、高温抗折强度30-70Mpa。产品有优良的抗水化性；游离态的金属铝使得产品具有优良的抗热震性。产品所用原料主要成分化学稳定性高、氧位低，并且不含碳和易水化的Al4C3，用于洁净钢连铸时不会发生二次C、O、H及其它杂质的污染。

摘要： 本发明涉及金属间化合物层状复合材料技术领域，公开了一种热等静压烧结Cf/Al‑Al/Al3Ti层状复合材料的制备方法，S1.根据复合材料的面密度要求，设计编织纤维Cf/Al复合材料层中纤维布、铝箔/板的厚度和层数，设计Al/Al3Ti金属间化合物复合材料层中铝箔/板、钛箔/板的厚度和层数；S2.将步骤S1中的纤维布、铝箔/板、钛箔/板等材料均裁剪成相同的设计尺寸，然后经处理后按一定的顺序进行排列，将排列好的材料装入低碳钢包套中，然后将包套抽成高真空后将抽气管压扁并封口，最后将包套放入热等静压炉中进行热压烧结，即得Cf/Al‑Al/Al3Ti层状复合材料。可利用其高抗冲击性和低面密度等性能，作为装甲防护材料使用。

摘要： 本发明Al3Sc‑Al3Zr/Al复合材料孕育剂的制备方法，涉及铝基合金，步骤是：依据目标合金中各组分元素的质量百分比为：Sc 1.00％～2.00％、Zr 1.00％～2.00％，其余为Al进行原料配制；块状Al‑Sc‑Zr中间合金的原位合成制备和超声处理；快速凝固技术制得薄带状Al3Sc‑Al3Zr/Al复合材料孕育剂产品。本发明方法用添加廉价Zr元素替代一部分价格高昂的Sc元素，降低了产品成本，克服了现有技术中形核颗粒不能在基体上弥散分布或弥散程度还不理想、颗粒在熔体中的聚集沉淀和颗粒尺寸大，Al‑Sc合金中Al3Sc颗粒尺寸过大和数量较少缺陷。

摘要： 提供具有高导电率和良好的加工性、且具有高强度的Al－Mg－Si系合金材料。将具有纤维组织的Al－Mg－Si系合金材料的抗拉强度设为280MPa以上，并将导电率设为54％IACS以上。

摘要： 本发明公开了Ni2Al3/α‑Al2O3刻蚀制备雷尼镍(Raney‑Ni)/α‑Al2O3的方法，包括如下步骤：按以下反应式称取市售NiO粉、Al粉，混合反应3h；6NiO+13Al→3Ni2Al3+2Al2O3；将所得的混合粉末置于SP‑3型行星式球磨机中进行机械球磨，以GCr15钢球作为研磨介质，球料比为30∶1，球磨机转速为400r/min，球磨过程，每球磨1h停20min，10h后，得Ni2Al3/α‑Al2O3粉体，取出；将所得的Ni2Al3/α‑Al2O3粉体用重量百分比为20％的NaOH溶液腐蚀2h，腐蚀过程中，反应容器置于70°C水浴中。本发明通过机械球磨NiO和Al混合粉末首先制备出Ni2Al3/α‑Al2O3粉体，再利用NaOH溶液刻蚀，则可制备Raney‑Ni/α‑Al2O3，制备工艺简单。