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辣椒辣素

辣椒辣素的相关文献在1991年到2022年内共计108篇,主要集中在外科学、中国医学、内科学 等领域,其中期刊论文104篇、会议论文3篇、专利文献112827篇;相关期刊71种,包括上海针灸杂志、现代生物医学进展、中国病理生理杂志等; 相关会议3种,包括2007年全国尿失禁与膀胱尿道功能障碍专题研讨会、中国针灸学会2005年学术年会、第三届全国中西医结合实验医学学术研讨会等;辣椒辣素的相关文献由274位作者贡献,包括关志忱、苏诚坚、董英伟等。

辣椒辣素—发文量

期刊论文>

论文:104 占比:0.09%

会议论文>

论文:3 占比:0.00%

专利文献>

论文:112827 占比:99.91%

总计:112934篇

辣椒辣素—发文趋势图

辣椒辣素

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  • 关志忱
  • 苏诚坚
  • 董英伟
  • 赵雷
  • 韩运峰
  • 何兆初
  • 区碧如
  • 吕寒静
  • 曾昭华
  • 汪新良
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 刘扣; 高翔; 陈可洋; 蒋正轩
    • 摘要: 目的 探讨辣椒辣素对糖尿病大鼠(DM)视网膜血管通透性及新生血管的影响。方法 选取8周龄雄性SD大鼠24只,随机分为4组(n=6):正常对照组(NC)、糖尿病组(DM)、糖尿病3 mg/kg辣椒辣素处理组(CAP3)、糖尿病6 mg/kg辣椒辣素处理组(CAP6)。3组糖尿病组大鼠均采用高脂饲料(HFD)+小剂量链脲佐菌素(STZ)联合诱导,建立2型糖尿病大鼠(T2DM)模型。监测4组大鼠体质量和空腹血糖。检测血清中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)浓度;伊文思蓝造影观察视网膜血管通透性改变;免疫荧光检测视网膜辣椒辣素受体1(TRPV1)分布;Western blot检测视网膜TRPV1、血管内皮生长因子(VEGF)、闭锁蛋白(occludin)水平。结果 与DM组相比,生化指标提示CAP3、CAP6组大鼠血清中TC、TG、LDL浓度降低(P<0.01);造影结果提示DM组大鼠视网膜血管通透性增高,存在多处强荧光渗漏区域,CAP3、CAP6处理组渗漏减轻;免疫荧光显示,CAP3、CAP6组视网膜神经节细胞层、内核层及外核层TRPV1激活;蛋白检测提示视网膜TRPV1升高,VEGF表达下降、occludin表达上升(P<0.01)。结论 辣椒辣素具有改善糖尿病视网膜病变作用,其机制可能是通过激活视网膜TRPV1受体,降低VEGF、升高occludin的表达。
    • 石晓志; 乔西民; 徐晓峰; 杜泉; 刘国雄
    • 摘要: 目的 评价膀胱简易水扩张对女性难治性膀胱过度活动症的治疗效果.方法 收集咸阳市中心医院2015年2月~2017年8月收治的女性难治性膀胱过度活动症患者62例,随机数字表法分为膀胱简易水扩张观察组和辣椒辣素对照组,每组各31例.观察指标:膀胱过度活动症症状评分表(OABSS)评分、日均排尿次数、夜尿次数、平均每次排尿量、初始尿意容量、最大膀胱容量.结果 两组治疗后OABSS评分、日均排尿次数、夜尿次数、每次排尿量、初始尿意容量、最大膀胱容量与治疗前比较,差异均有统计学意义(P<0.05).治疗后1周,观察组在夜尿次数、日均每次排尿量、初始尿意容积、最大膀胱容量与对照组比较,差异有统计学意义(P<0.05).治疗后3个月,两组日均排尿次数、最大膀胱容量比较,差异有统计学意义(P<0.05).观察组与对照组临床治疗有效率比较,差异无统计学意义(P> 0.05).结论 膀胱简易水扩张可以作为难治性膀胱过度活动症的一个治疗方法的补充.
    • 宋莉; 董英伟; 闫全章; 张宁宁; 陈荣权
    • 摘要: 目的:观察不同浓度辣椒辣素对小鼠慢性膝关节炎疼痛模型的治疗效果.方法:选择健康成年雄性昆明小鼠50只,通过左膝关节腔内注射0.01 mL完全性弗氏佐剂(Complete Freund's Adjuvant,CFA)建立慢性膝关节炎疼痛模型,3周后建模成功.随后,将造模成功的小鼠随机分为五组(n=10):实验一组(生理盐水组)、实验二组(辣椒辣素赋形剂组)、实验三组(0.5%的辣椒辣素组)、实验四组(3%的辣椒辣素组)、实验五组(8%的辣椒辣素组).观察注药后1、4、7小时的热缩足反射时间以及注药后60天内的热缩足反射时间.结果:①生理盐水组与辣椒辣素赋形剂组注药后1、4、7小时的热缩足反射时间以及注药后60天内的热缩足反射时间比较差异均无统计学意义(P>0.05).②实验三组注射辣椒辣素后产生的急性疼痛于注药后7小时恢复,实验四组小鼠的急性疼痛期于注药后4小时恢复,实验五组小鼠的急性疼痛期于注药后1小时恢复.③实验三组镇痛时间持续18.9±1.1天,实验四组镇痛时间持续33.7± 1.0天,实验五组镇痛时间持续58.2± 1.2天.结论:辣椒辣素对于CFA所致慢性膝关节炎疼痛模型具有镇痛作用,并且镇痛作用时间随着辣椒辣素的浓度增加而延长.%Objective:To observe the therapeutic effect ofcapsaicin at different concentrations on chronic knee arthritis pain model in mice.Methods:Choosing 50 healthy adult male Kunming mice builded chronic knee arthritis pain model by injecting 0.01 mL CFA (Complete Freund's Adjuvant,CFA) into left joint cavity.The model would be succeed in building after 3 weeks.The successful model mice were divided into five groups randomly (n=10):The first experimental group (saline group),the second experimental group (capsaicin excipient group),the third experimental group (0.5 % of capsaicin),the fourth experimental group (3 % of capsaicin) and the fifth experimental group (8 % of capsaicin).All of the mice would be observed the time of withdrawal latencies from the thermal heated surface after administration of one,four and seven hours,and thermal withdrawal time within 60 days after the injection.Results:①The physiological saline group compared with excipient group,the thermal withdrawal time had no statistically significant difference (P>0.05)after administration of one,four and seven hours,and thermal withdrawal time within 60 days.②The acute pain duration of the third group would disappear after capsaicin injection 7 hours,four hours for the fourth group,and one hour for the fifth group.③The duration of analgesia of the third group,lasted for 18.9± 1.1 days;The analgesia time of the fourth group lasted for 33.7± 1.0 days;The analgesia time of the fifth group lasted for 58.2± 1.2 days.Conclusions:Capsaicin has analgesic effects on chronic knee pain model in mice induced by CFA,and the days of analgesia increases with the concentration of capsaicin.
    • 孙玉; 刘佳; 宁波; 杨朝霞
    • 摘要: 目的 探讨辣椒素对脂肪变肝细胞内脂质沉积的影响及自噬表达情况,为脂肪性肝病防治的研究提供新的思路和靶点.方法 用油酸(40 μg/mL)诱导肝原代细胞LO2细胞株建立非酒精性脂肪性肝病(NAFLD)细胞模型.实验分为空白对照组、油酸组、辣椒素组[油酸+辣椒素(100 μmol/L)].油红O染色和三酰甘油试剂盒检测肝细胞内脂肪变程度;Western blot检测自噬体标记分子p62和LC3的表达水平并计算LC3Ⅱ/LC3 Ⅰ比值.结果 40 μg/mL油酸处理LO2细胞24h后,油红O染色观察,油酸组肝细胞中可见大小不等的橘红色脂滴.而空白对照组无明显橘红色脂滴形成,油酸在体外成功建立NAFLD模型.与油酸组相比,辣椒素组肝细胞内三酰甘油水平显著降低(P<0.05),脂滴明显减少,p62蛋白水平明显降低(P<0.05),而LC3-Ⅱ/LC3-Ⅰ比值明显上调(P<0.05).结论 在体外利用油酸诱导LO2细胞株建立NAFLD模型,辣椒素刺激NAFLD细胞,上调NAFLD细胞自噬水平,减少细胞内脂质沉积,但具体机制还需进一步研究.%Objective To observe the effect of capsaicin on lipid deposition in liver cells and the expression of autophagy,to provide new ideas and targets for the study of fatty liver disease.Methods The model of nonalcoholic fatty liver disease (NAFLD) was established by inducing LGF cell line of liver primary cells with oleic acid (40 μg/mL).The experiment was divided into blank control group,oleic acid group,capsaicin group[oleic acid--capsaicin(100 μmol/L)].The level of intracellular lipid was detected by oil red O staining and triglyceride (TG) kit.Western bolt was used to detect the expression level of autophagy marker molecule p62 and LC3,and to calculate the ratio of LC3 Ⅱ/LC3-Ⅰ.Results After treated with 40 μg/mL oleic acid for 24 h,the oil red O staining showed that orange-red lipid droplets were found in the oleic acid group,but there was no obvious orange-red lipid droplet formation in the blank group,which suggesting that the NAFLD cell model was established successfully by using 40 μg/mL oleic acid in vitro.Oil red O staining was observed,the cells in the capsaicin group were significantly less than the oleic acid group,and the content of triglyceride in the liver cells was significantly lower than that in the oleic acid group(P<0.05).Western bolt test results showed that capsaicin group p62 protein levels were significantly lower compared with the oleic acid group(P<0.05),while the LC3-Ⅱ/LC3-Ⅰ ratio was higher than that of oleic acid group(P<0.05).Conclusion NAFLD model was established by inactivating LO2 cell line with oleic acid in vitro.Capsaicin stimulated NAFLD cells,upregulated the autophagy level of NAFLD cells and reduced intracellular lipid deposition,but the specific mechanism need further study.
    • 孟颖; 李兔平; 郭政
    • 摘要: Objective To evaluate the effect of capsaicin on cardiac dysfunction in diabetic rats u-sing an in vitro experiment. Methods Healthy male Sprague-Dawley rats, weighing 240-260 g, in which type 1 diabetes mellitus was induced by intraperitoneal streptozotocin 50 mg∕kg, were studied. Eighteen di-abetic rats were selected at 8 weeks after successful establishment of the model and divided into 3 groups (n=6 each)using a random number table: diabetes mellitus group(DM group), capsaicin group(CAP group)and capsaicin plus capsazepine group(CPZ group). Another 8 rats with normal blood glucose served as control group(C group). Rat hearts were quickly removed under deep anesthesia and retrogradely perfused with an oxygen-saturated K-H solution(at 37°C)using a Langendorff apparatus. Cardiac function was maintained stable for 10 min. The hearts were continuously perfused with K-H solution for 30 min in C and DM groups. The hearts were perfused with K-H solution for 20 min, and capsaicin(1.4×10-9g∕L)was then infused for 10 min via the branch of aortic cannula using micro pump in CAP group. The hearts were perfused with K-H solution for 10 min, and capsaicin receptor-transient receptor potential vanilloid type 1 antagonist capsazepine(1.4×10-7g∕L)was then infused for 10 min followed by infusion of capsaicin(1.4× 10-9g∕L)at 0.5 ml∕min for 10 min via the branch of aortic cannula using a micro-pump in CPZ group. Left ventricular systolic pressure(LVSP), left ventricular developed pressure(LVDP), left ventricular end-di-astolic pressure(LVEDP), heart rate, the maximum rate of increase or decrease in left ventricular pres-sure(±dp∕dtmax)were recorded at 10, 20 and 30 min of continuous infusion(T1-3). Results There was no significant difference in LVEDP and ± dp∕dtmaxat each time point among the four groups(P>0.05). Compared with C group, LVSP and LVDP were significantly decreased at T1-3in DM and CPZ groups and at T1-2in CAP group, and heart rate was significantly decreased at T1-3in DM, CPZ and CAP groups(P0.05). LVSP and LVDP were significantly lower at T3in CPZ group than in CAP group(P0.05);与C组比较,DM组和CPZ组T1-3时、CAP组T1-2时LVSP和LVDP降低,DM组、CPZ组和CAP组T1-3时HR降低(P0.05);与CAP组比较,CPZ组T3时LVSP和LVDP降低(P<0.05).结论 辣椒素可减轻糖尿病大鼠离体心脏障碍功能,其机制与激活瞬时感受器电位香草酸受体1有关.
    • 李金芳; 宋百灵; 张唯; 李新霞
    • 摘要: Objective To establish a method for determination of two components in natural capsaicin by one reference substance . Methods Quantitative analysis of multi‐components was performed to determine the contents of dihydrocapsaicin and capsaicin with capsaicin as the reference substance by single‐maker(QAMS) and HPLC .Results The relative correction factor between capsaicin and dihydrocapsaicin was 1 .12 .There was no significant difference of the measured values between the external standard method and QAMS (P>0 .05) .With capsaicin retention time of 1 .00 ,the relative retention time of dihydrocapsaicin was 1 .355 and the RSD was less than 5% .Conclusion With capsaicin as a single marker and the relative correction factor of dihydrocapsai‐cin ,QAMS could be applied for the determination of the main components of natural capsaicin extract simultaneously .%目的:建立以1种对照品同时测定天然辣椒碱中2种成分的质量评价方法。方法以辣椒辣素为对照,采用一测多评法,同时测定辣椒辣素和二氢辣椒辣素的含量。结果测得辣椒辣素与二氢辣椒辣素的相对校正因子为1.12,同时采用外标法和一测多评法测定样品中二氢辣椒辣素含量,采用 t检验对二者测定值进行比较,二者之间无显著差异(P>0.05);以辣椒辣素的保留时间为1.00,计算得二氢辣椒辣素的相对保留时间为1.355,相对保留时间及保留时间差的RSD均小于5%。结论采用一测多评法,以辣椒辣素为对照,利用相对校正因子可实现同时测定辣椒辣素和二氢辣椒辣素的含量。
    • 胡容; 史孝敏; 唐川康; 彭燕; 罗旭娟
    • 摘要: 目的 研究小剂量辣椒素(Cap)在不同时期对大鼠内脏机械及化学刺激敏感性的影响.方法 SD大鼠160只,随机分为对照组(普通饲料)和观察组(Cap 1 mg· kg-1·d-1),每组80只,再各随机均分为5组,雌雄各半,分别在干预1d、3d、1周、2周和4周后,采用直肠气囊扩张法观察大鼠内脏机械刺激敏感性,腹腔注射新斯的明法观察内脏化学刺激敏感性,采用免疫组化法检测胃、十二指肠黏膜辣椒素受体(TRPV1)的表达情况.结果 在机械刺激敏感性实验中,与对照组相比较,喂食Cap 1周,观察组大鼠气囊扩张体积显著减少(P=0.002),且雌性较雄性更敏感(P=0.001);喂食Cap 4周,观察组大鼠气囊扩张体积显著增加(P=0.007).在化学刺激敏感性实验中,与对照组相比较,喂食Cap 1周,观察组大鼠腹痛相关行为的持续时间显著延长(P=0.001);而喂食Cap 4周,观察组大鼠腹痛相关行为的开始时间显著延长(P=0.02);其余各组之间差异无显著意义(P>0.05).观察组在给予Cap1 d、3d、1周后胃黏膜TRPV1的表达显著高于对照组(P<0.05),给予Cap1d、3d后十二指肠黏膜TRPV1表达显著高于对照组(P<0.05),随后观察组和对照组TRPV1的表达均无显著差异(P>0.05).结论 连续摄入小剂量Cap 1周后,大鼠对内脏机械及化学刺激的敏感性显著增加,2周后恢复正常,4周后显著降低,其中雌性对内脏机械刺激较雄性更为敏感.小剂量Cap可以调节胃、十二指肠组织TRPV1的表达.
    • 陈荣权; 刘丽娜; 董英伟
    • 摘要: 目的:探讨辣椒辣素神经周围给药对大鼠神经病理性疼痛的影响.方法:雄性Wistar大鼠48只,体重200~250 g,采用随机数字表法随机分为6组(n=8),包括正常对照组(N组),假手术组(S组),赋形剂预处理组(PV组),辣椒辣素预处理组(PC组),神经病理性疼痛+赋形剂组(LV组),神经病理性疼痛+辣椒辣素组(LC组).N组、S组、PV组和PC组分别在神经结扎前1d,术后第7、10、14 d测定机械性缩足反射阈值(mechanical withdrawal threshold,MWT)和热缩足潜伏期(thermalwithdrawal latency,TWL),其中MWT用差异性评分表示.LV组和LC组分别在神经结扎前1d,术后第7d、给药后4h(第7d)、24 h(第8d)、第9、10和14d测定MWT和TWL.结果:PC组术后各时间点MWT比PV组显著上升(P< 0.05);PC组术后各时间点TWL也比PV组明显延长(P<0.05);LC组MWT在注射辣椒辣素后4h(第7d)和24 h(第8d)比LV组明显上升(P<0.05); LC组TWL在注射辣椒辣素后4h(第7d)、24h(第8d)、第9d和第10d均比LV组明显延长(P<0.05).结论:辣椒辣素单次坐骨神经周围给药可以减轻神经松弛结扎引起的痛觉过敏.辣椒辣素预处理可以减轻神经病理性疼痛模型的疼痛程度.
    • 党军强; 陈媛; 林文; 李长彬
    • 摘要: 胰腺癌是恶性程度很高的肿瘤,5年生存率低于5%.随着诊疗技术的进步,胰腺癌患者症状得到了极大的改善,但其预后仍不乐观.近年来,来自于自然界的抗肿瘤植物得到了广泛关注.大量的实验室研究和临床试验表明姜黄素、异硫氰酸盐类、辣椒辣素、儿茶素等植物相关产品同降低肿瘤发病率之间有密切的相关性.%Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%.Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poorprognosis.Recently,compounds from naturalsources receive ample attention as anti-cancer agents.Overwhelming in vitro evidence and clinical trials suggest that curcuminn,isothiocyanate,capsaicin,catechin may reduce the incidence of cancer.
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