摘要：
目的 观察跑轮和跑台两种不同预运动方式对磨牙缺失大鼠学习记忆能力的影响.方法 选取32只3月龄健康雄性SD大鼠,将所有大鼠按照随机数字表法分为对照组(C组)、磨牙缺失组(ML组)、跑轮预运动磨牙缺失组(W-ML组)、跑台预运动磨牙缺失组(T-ML组),每组8只.T-ML组和W-ML组大鼠进行为期1周的预运动训练,对T-ML组大鼠进行跑台预运动干预,对W-ML组大鼠进行跑轮预运动干预.ML组和C组大鼠在正常鼠笼里自由饲养.运动结束后,T-ML、W-ML组和ML组大鼠均接受单侧磨牙拔除手术.1周后,采用被动回避反射实验来评价各组大鼠的学习记忆能力.结果 在训练阶段,C组、ML组、W-ML组、T-ML组的潜伏期Ⅰ分别为(58.00±11.41)s、(65.33±11.39)s、(64.33±14.06)s、(63.33±14.32)s.在实验阶段,C组、ML组、W-ML组、T-ML组的潜伏期Ⅱ分别为(300.00±0.00)s、(69.21±12.19)s、(300.00±0.00)s、(300.00±0.00)s.训练阶段,4组大鼠的潜伏期I间比较,差异无统计学意义(P＞0.05).实验阶段,与C组比较,ML组大鼠潜伏期Ⅱ显著降低(P＜0.05);与ML组比较,W-ML组和T-ML组潜伏期Ⅱ显著升高(P＜0.05),W-ML组与T-ML组间比较,差异无统计学意义(P＞0.05).结论 跑台和跑轮两种不同预运动方式均可改善磨牙缺失后大鼠的学习记忆能力.%Objective To observe the effect of wheel running and treadmill running on the cognitive functioning of rats after the extraction of a molar.Methods Thirty-two Sprague-Dawley rats were randomly divided into a control group (group C,n =8),a molar extraction group (ML group,n =8),a wheel running pretreatment group (W-ML group,n=8) and a treadmill running pretreatment group (T-ML group,n =8).The rats in the T-ML and W-ML groups practiced wheel running and treadmill running for 1 week,then they and the rats in the ML group received molar extraction surgery.One week later,a passive avoidance test was used to evaluate the cognitive functioning of all of the rats.Results No significant differences were found in the groups' average latency I times,but the average latency II time of the ML group was significantly shorter.There was no significant difference in the average latency II times of the T-ML and W-ML groups.Conclusion Either wheel running or treadmill running can promote learning and memory after molar loss by oral surgery,at least in rats.
