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超排卵

超排卵的相关文献在1990年到2022年内共计228篇,主要集中在妇产科学、基础医学、中国医学 等领域,其中期刊论文211篇、会议论文4篇、专利文献94710篇;相关期刊105种,包括国际生殖健康/计划生育杂志、中国计划生育学杂志、中国计划生育和妇产科等; 相关会议4种,包括中华医学会生殖医学分会第二次全国生殖临床学术研讨会、第五届中国北方实验动物科技年会、第二届全国多囊卵巢综合征及其相关疾病诊治新进展专题研讨会等;超排卵的相关文献由620位作者贡献,包括申可佳、付灵梅、周生来等。

超排卵—发文量

期刊论文>

论文:211 占比:0.22%

会议论文>

论文:4 占比:0.00%

专利文献>

论文:94710 占比:99.77%

总计:94925篇

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超排卵

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  • 申可佳
  • 付灵梅
  • 周生来
  • 尤昭玲
  • 熊桀
  • 谭丽
  • 黄荷凤
  • 李尚为
  • 杨葳
  • 郑志红
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 李文澍; 刘雪梅
    • 摘要: 促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonists,GnRHa)广泛运用于体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)垂体降调节中,并衍生出多种不同控制性促排卵方案,其中卵泡期长效长方案已应用于子宫内膜异位症、卵巢储备正常、多囊卵巢综合征和卵巢低反应等患者的促排卵中,并被证实可改善子宫内膜容受性和胚胎质量,较其他方案有更高的胚胎种植率和临床妊娠率.
    • 陈宥艺; 段海霞; 安静; 赵静
    • 摘要: 目的:探讨控制性超促排卵黄体期患者血清孕酮(P)、雌二醇(E2)及白细胞介素-1β(IL-1β)水平对胚胎着床的影响.方法:选择80例体外受精-胚胎移植(IVF-ET)患者,所有患者均采用黄体期长方案促排卵治疗,于新鲜周期移植后第7天采集静脉血检测血清P、E2及IL-1β水平,观察胚胎着床妊娠情况,对比妊娠组(n=31)与非妊娠组(n=49)血清指标的差异,通过Logistic回归分析血清P、E2及IL-1β水平对胚胎着床的影响.结果:妊娠组获卵数、受精率、优质胚胎率均高于非妊娠组(P<0.05);妊娠组血清P、IL-1β水平以及P/E2比值高于非妊娠组(P<0.05);妊娠组E2水平低于非妊娠组(P<0.05);黄体期血清P/E2值为300~400时的妊娠率62.50%,P/E2值<300时的妊娠率27.27%,P/E2值≥400时的妊娠率33.33%(P<0.05);黄体期血清IL-1β≥80 pg/ml时妊娠率达到64.52%,高于IL-1β<80 pg/ml的妊娠率22.45%(P<0.05);Logisitic回归分析显示年龄、移植胚胎级别、血清P/E2、IL-1β是着床成功的影响因素.结论:黄体期长方案超促排卵后黄体期血清P/E2比值为300~400,IL-1β水平高于80 pg/ml时着床成功的可能性更高.
    • 何岩; 于洋; 董婉维; 周生来; 王惟; 杨葳; 郑志红
    • 摘要: 目的 研究脱氢表雄酮(DHEA)对C57BL/6J雌鼠超排卵效果和卵母细胞质量的影响及其机制.方法 3周龄C57BL/6J雌鼠30只随机分为3组,分别为对照组、低剂量处理组(2 mg/kg·d-1)和高剂量处理组(5 mg/kg·d-1).用DHEA灌胃1周,再经超排卵后分别进行体外受精和收集卵丘细胞.提取卵丘细胞RNA进行qRT-PCR检测与胚胎质量相关基因Grem1、Has2、Ptgs1、Ptgs2和Vcan的mRNA水平以及凋亡相关基因Caspase3和Bcl2l10的mRNA水平.结果 经过DHEA处理的雌鼠超排卵后,体外受精(IVF)显示实验组异型卵比例下降.实验组卵丘细胞中与胚胎质量相关基因Has2,Ptsg1和Vcan转录水平与对照组相比上调,而Germ1和Ptgs2的mRNA水平下调.Caspase3的mRNA水平下调,Bcl2l10的mRNA水平上调.结论 经过DHEA处理后可以通过抑制卵丘细胞凋亡,提高卵母细胞的质量.
    • 孔慧娟; 卜志勤; 王芳; 苏迎春
    • 摘要: 目的:分析行体外受精/卵胞浆内单精子显微注射(IVF/ICSI)的25岁及以下女性的助孕特征及结局.方法:回顾性分析第一周期行IVF/ICSI助孕的12350例患者的临床资料,其中女性年龄20~岁522例,23~岁3030例,26~30岁8798例.比较3个年龄组患者的临床特征、助孕过程及妊娠结局.结果:3组不孕年限、男性因素不孕者占比、促性腺激素(Gn)用量和使用时间、HCG日雌二醇水平、ICSI占比差异均有统计学意义(P0.05).结论:IVF/ICSI助孕时,20~岁、23~岁及26~30岁女性生育能力基本相同.
    • 张祥
    • 摘要: 卵巢低反应(poor ovarian response,POR)是卵巢对促性腺激素(Gn)刺激反应不良的病理状态,患者在控制性超促排卵(COH)中效果不理想,体外受精-胚胎移植(IVF-ET)妊娠率低下.如今对于POR的常规治疗仍存在局限.针刺疗法作为祖国传统医学的重要组成部分,操作简便,经济安全.目前临床针刺治疗POR包括毫针刺法、经皮穴位电刺激(TEAS)和针药结合等方法.研究表明POR患者经针刺治疗后基础内分泌、肾虚症状和卵巢功能等有所改善,接受IVF-ET患者获卵数与妊娠率有所提高.其治疗机制可能是通过调节中枢相关神经元活性和下丘脑-垂体-卵巢轴的分泌功能,改善血清性激素水平和卵巢血液供应,提高IVF-ET妊娠率.现将针刺治疗POR的临床研究进展从治疗的机制、方法、疗效、安全性等方面进行综述.
    • 许远芳; 黄元华
    • 摘要: 近年研究发现血清抗苗勒管激素(AMH)水平作为评估卵巢储备能力及辅助生殖技术(ART)结局的指标已显示出其优越性,且AMH与多囊卵巢综合征(PCOS)的关系引起了学者们的关注.PCOS患者的卵巢储备异于同年龄非PCOS者,其实际年龄不等同于卵巢生育年龄,存在生育年龄后移情况,且在卵巢储备方面优于同年龄非PCOS者.AMH在PCOS患者的表达及变化有其特殊性,其在PCOS患者中异常升高,且随着年龄的下降速率较同年龄妇女更快.AMH水平与PCOS患者的基础窦卵泡数(AFC)及控制性超促排卵(COS)过程中的获卵数呈正相关,但与体外受精-胚胎移植(IVF-ET)妊娠结局的相关性存在争议.AMH对PCOS的诊断效能良好,但因AMH的升高与PCOS患者的具体表型及种族差异有关,故其截断值波动范围较大,目前尚无统一定论.
    • 陈艳花; 连方; 张雪洛; 柳俊珍; 崔向荣
    • 摘要: Objective:In view of GVBD and extrusion of PB1, to explore the mechanism of Er-zhi Tiangui (ETG) granule to improve the quality of oocyte, the ratio of good quality embryo in superovulation cycle. Method:165 Kunming female mice were divided into three groups randomly. The mice in treatment group and control group were given HMG and HCG for ovarian stimulation, 0.9% salt solution and ETG were respectively administered by gastric infusion to control group and treatment group on the same time schedule. The mice in blank group were given nothing. Three groups were divided into1 st group、2nd group each. All mice in 1st group were sacrificed and denuded oocytes (Dos) on germinal vesicle stage were taken out to observe extrusion of PB1. The oocytes were collected to detect expression of GDNF、GFR-1mRNA. The mice in 2nd group of treatment group and control group mated by rate of 1∶1 after the day of HCG injection, mice were retrieved to evaluate the ability of merogenesis and forming the embryo in the next day. The mice in blank group mated by rate of 1∶1on the day of estrus cycle, On the next day when vaginal suppository were found, then zygotes were retrieved to evaluate the ability of merogenesis and forming the embryo. Result:The ratio of germinal veicles breakdown and extrusion of the first polar body in treatment group was significantly higher than those of control group. The rate a of cleavage and forming the embryo in control group were lower than those of the treatment group (P<0.05). The expression of GFRa-l mRNA in the oocytes of the treatment group was higher than that of the control group (P<0.05). Conclusion:ETG can improve the embryo quality may be related to its effect on germinal veicles breakdown and extrusion of the first polar body, and can improve the expression of GFR-1 mRNA in oocytes.Then ETG can improve the ability of merogenesis and forming the embryo of fertilized ovum.%目的:从卵母细胞生殖泡裂解(GVBD)、第一极体的排出(PB1)的角度,探讨二至天癸颗粒改善卵母细胞质量及优胚率的可能机制.方法:将165只小鼠随机分为空白组、治疗组及对照组.治疗组及对照组用注射用尿促性素(HMG)和注射用绒促性素(HCG)超排卵,连续灌胃给药(治疗组用二至天癸颗粒,对照组用等量生理盐水),空白组无超排卵及灌胃给药等治疗.3组又各分为1、2两组.治疗组与对照组腹腔注射HMG 48 h后,空白组于动情周期当天,全部1组脱颈处死小鼠,取GV期DOs,观察PB1排出,收集卵母细胞,之后成熟卵母细胞行胶质细胞源性神经营养因子(GDNF)、家族特异性受体a-1(GFR-1)mRNA的表达检测.治疗组与对照组2组5只小鼠腹腔注射HCG10 IU,按雌∶雄=1∶1比例分别合笼饲养,合笼次日作为妊娠第1天.取受精卵,观察卵裂率、成胚率.空白组于确定发现阴道动情周期当天为第0天,即合笼,第2天晨发现阴道栓后,取受精卵,观察卵裂率、成胚率.结果:治疗组GV期卵母细胞GVBD率、PB1排出率均高于对照组,差异有统计学意义(P<0.05);小鼠受精卵卵裂率及成胚率,治疗组与对照组比较,差异有统计学意义(P<0.05).治疗组卵母细胞GFR-1mRNA的表达明显高于对照组(P<0.05).结论:二至天癸颗粒提高小鼠卵母细胞GFR-1mRNA的表达,促进卵母细胞GVBD和PB1的排出,改善了卵母细胞成熟度,提高卵细胞质量,从而提高胚胎质量.
    • 摘要: 抑制素是由卵巢的颗粒细胞和卵泡膜细胞以及睾丸的支持细胞产生的糖蛋白.抑制素免疫已被用于改善动物繁殖力,特别是对提高单胎动物繁殖力有重要意义.本文对抑制素免疫的作用机制和应用方面的研究进展加以阐述,并在此基础上提出了进一步的展望,旨在促进抑制素免疫在动物繁殖领域更好地应用.
    • 巩雪洁; 臧敦安; 许文豪
    • 摘要: [目的]探讨不同周龄、不同初始注射时间对小鼠超数排卵效果的影响.[方法]用10 IU PMSG+10 IU HCG 间隔48 h 处理C57BL/6J小鼠,收集并统计合子数.[结果]4周龄超排效果优于于8周龄,可达26.86枚∕只;4周龄C57BL/6J小鼠PMSG和HCG注射时间为12:00—13:00,超排后收集合子数可达30枚∕只以上,而且体外培养的发育状况良好.[结论]4周龄C57BL/6J小鼠适宜超数排卵;PMSG和HCG注射时间为12:00—13:00,超排效果相对理想.%[Objective]To discuss the influence of week-age and initial injection time on superovulation in mice.[Method]The C57BL/6J mice were treated with 10 IU PMSG+10 IU HCG interval 48h,and the number of zygotes was collected and counted.[Result]The effect of the four week age superovulation was better than that of eight weeks,and it could reach 26.86.The time of PMSG and HCG injection of C57BL/6J mice at 4 weeks old was 12-13 at noon,and the number of zygotes collected was up to 30 and in vitro culture of the fertilized ovum was in good condi-tion.[Conclusion]The 4-week old C57BL/6J mice are suitable for superovulation.When the injection time of PMSG and HCG is 12-13 at noon, the superovulation effect is relatively ideal.
    • 倪丹; 刘雨生; 吴莉; 季静娟; 童先宏
    • 摘要: 目的:了解基础黄体生成激素(LH)<2 IU/L患者行长方案体外受精/胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)的卵巢反应性及助孕结局,探讨其作为单项指标与卵巢储备功能的相关性.方法:选择2014年1月--2017年3月在安徽医科大学附属省立医院行IVF/ICSI-ET且基础卵泡刺激素(FSH)< 10 IU/L的患者.根据患者年龄和LH水平分为4组,即A组:年龄≤35岁[25~35岁,平均年龄(28.86±3.10)岁],LH<2 IU/L,88例;B组:年龄≤35岁[25~35岁,平均年龄(28.48±3.72)岁],LH 2~5 IU/L,226例;C组:年龄>35岁[36~42岁,平均年龄(38.54±2.84)岁],LH<2 IU/L,24例;D组:年龄>35岁[36~42岁,平均年龄(37.64±2.40)岁],LH 2~5 IU/L,58例.对4组的超促排卵、胚胎数量和质量以及妊娠率相关数据进行比较.结果:A组基础日、降调日和促性腺激素(Gn)启动日LH水平低于B组,差异均有统计学意义(P<0.05);A组Gn总量较B组增加但差异无统计学意义(P>0.05);人绒毛膜促性腺激素(hCG)日E2水平、直径大于14 mm的卵泡数、获卵数、2原核(PN)胚胎数、优质胚胎数均低于B组,差异有统计学意义(P<0.05).A组的FSH/LH均值为4.06.C组基础日、降调日和Gn启动日LH水平低于D组,差异均有统计学意义(P<0.05);C组Gn总量较D组增加但差异无统计学意义(P>0.05);C组hCG日E2水平、直径>14 mm的卵泡数、获卵数、2PN胚胎数、优质胚胎数与D组比较,差异无统计学意义(P>0.05).C组的FSH/LH均值为4.23.A组与B组比较、C组与D组比较,hCG日LH水平、生化妊娠率和临床妊娠率差异均无统计学意义(P>0.05).结论:年龄≤35岁且基础LH<2 IU/L,可以反映卵巢储备功能的状态并指导超排卵方案的选择.%Objective:To study the ovarian response and IVF/ICSI-ET outcome of the long GnRH-a protocol in those patients with base LH <2 IU/L,so as to explore the correlation of LH as a single index and ovarian reserve.Methods:Those patients undergoing IVF/ICSI-ET with the base FSH <10 IU/L from January 2014 to March 2017 were enrolled.According to the age and the base LH level,those patients were divided into four groups,the group A:age ≤35 years [25~35 years old,the average age (28.86±3.10)] and base LH<2 IU/L (n=88);the group B:age ≤ 35 years [25~35 years old,the average age (28.48±3.72)] and base LH 2~5 IU/L (n=226);the group C:age >35 years [36~42 years old,the average age (38.54±2.84)] and base LH<2 IU/L (n=24);the group D:age >35 years[36~42 years old,the average age (37.64±2.40)] and base LH 2~5 IU/L (n=58).The superovulation rate,the quantity and quality of embryo,and the pregnancy rate were compared.Results:The base LH level and LH levels on the down-regulated day and Gn starting day in the group A were significantly lower than those in the group B (P<0.05),while the total dose of Gn in the group A was higher than the group B (However,P>0.05).The E2 level on the day of hCG injection,the number of ≥ 14 mm follicles,the retrieved oocyte number,the number of 2PN and the number of high quality embryos in the group A were significantly lower than those in the group B (all P<0.05).The FSH/LH ratio in the group A was 4.06.The base LH level and LH levels on the down-regulated day and Gn starting day in the group C were significantly lower than those in the group D (P<0.05),while the total dose of Gn in the group C was higher (However,P>0.05).There were no significant differences in the E2 level on the day of hCG injection,the number of ≥ 14 mm follicles,the retrieved oocyte number,the number of 2PN and the number of high quality between the group A and group B (all P>0.05).The FSH/LH ratio in the group C was 4.23.Interestingly,there were no significantly differences in the LH level on the day of hCG injection,the rate of biochemical pregnancy and the rate of clinical pregnancy between the group A and group B,or between the group C and group D (both P>0.05).Conclusions:The age ≤35 and base LH <2 IU/L,as two parameters of ovarian reserve function,can be used as clinical references of ovarian stimulation protocols.
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