您现在的位置: 首页> 研究主题> 谷峰比值

谷峰比值

谷峰比值的相关文献在1996年到2016年内共计79篇,主要集中在内科学、药学、临床医学 等领域,其中期刊论文78篇、会议论文1篇、专利文献723篇;相关期刊60种,包括现代中西医结合杂志、实用医院临床杂志、中华综合临床医学等; 相关会议1种,包括全国中西医结合防治心脑血管疾病学术大会等;谷峰比值的相关文献由213位作者贡献,包括孙宁玲、柯元南、陈源源等。

谷峰比值—发文量

期刊论文>

论文:78 占比:9.73%

会议论文>

论文:1 占比:0.12%

专利文献>

论文:723 占比:90.15%

总计:802篇

谷峰比值—发文趋势图

谷峰比值

-研究学者

  • 孙宁玲
  • 柯元南
  • 陈源源
  • 刘勇
  • 卢熙宁
  • 吴波
  • 吴海松
  • 周晓芳
  • 张丽杰
  • 张小艳
  • 期刊论文
  • 会议论文
  • 专利文献

搜索

排序:

学科

年份

    • 李振华; 刘小玲; 李卫国; 张萍; 热依拉
    • 摘要: 目的:探讨苯磺酸氨氯地平(络活喜)对中国部分少数民族与汉族高血压患者谷峰比值( T/P)和平滑指数( SI)的影响。方法对120例高血压患者分为少数民族组(维吾尔族、柯尔克孜族、塔吉克族)和汉族组,每组60例,用络活喜,每日晨起1片,服药6 w,并在治疗前后进行24 h动态血压监测(24 h ABPM),计算血压水平、T/P和SI。结果治疗6 w后两组24 h收缩压(SBP)和舒张压(DBP);白昼 SBP和DBP;夜间SBP和DBP与治疗前相比有显著差异(P<0.05),少数民族组T/P为SBP 68%,DBP 65%,SI为SBP(1.52±0.61),DBP(1.25±0.46);汉族组 T/P为SBP 69%;DBP 67%,SI为SBP(1.48±0.65),DBP(1.35±0.51);而两组间T/P和SI治疗后相比较无统计学差异(P>0.05)。结论络活喜治疗部分少数民族高血压和汉族高血压T/P比值与SI均效果良好。
    • 龙华晴; 吴人照; 何晓艳; 杨兵勋; 楼正家; 杨芳亮; 陈宇
    • 摘要: 目的:观察铁皮石斛花水提物对SHR大鼠的降压平稳性和量效关系.方法:自发性高血压大鼠(SHR)32只随机分为四组:模型组,铁皮石斛花高、中、低剂量组(4.5g/kg、1.5g/kg、0.5g/kg).另正常Wistar大鼠16只随机分为正常对照组、正常中剂量组(1.5g/kg)两组.连续灌胃8周,每周测量一次血压.8周后停药1周进入第二阶段,连续倍量灌胃7周,即模型组,铁皮石斛花高、中、低剂量组(9.0g/kg、3.0g/kg、1.0g/kg),正常对照组和正常中剂量组(3.0g/kg)6组,每周测量血压当天均测量给药前(相当于给药24小时水平)、给药1小时和2小时血压,计算降压谷峰比值.结果:16周观察期间血压呈剂量相关性降低.高剂量组SBP给药后1小时较模型组下降44.78mmHg,给药24小时较模型组下降31.54mmHg,降压谷峰比为70.43%,DBP给药后1小时较模型组下降30.73mmHg,给药24小时较模型组下降26.79mmHg,降压谷峰比为87.18%.结论:铁皮石斛花水提物有平稳的降压效果,降压谷峰比值大于50%.连续灌胃可以抑制SHR血压随年龄增长而增加的趋势.
    • 荆珊; 陈源源; 孙宁玲; 柯元南; 羊镇宇
    • 摘要: Objective To evaluate the efficacy of Nebivolol on patients with mild or moderate essential hypertension(EH) using different methods of ambulatory blood pressure monitoring.Methods Forty-seven patients with mild or moderate EH were enrolled as our subjects after a 2-week administration of placebo.They were administrated Nebivolol (5 mg) once daily for 12 weeks.All the patients completed ambulatory blood pressure monitoring before and after taking Nebivolol for 12 weeks.The overall and individual methods were used to calculate the trough-to-peak ratio (T/P ratio) and smooth index (SI).Results (1) For all of 42 patients treated with Nebivolol (5 mg) for 12 weeks,the systolic blood pressure(SBP),diastolic blood pressure(DBP) of the whole-day,daytime and nighttime after treatment were decreased compared to before treatment (the whole day:(144.1 ± 9.8),(124.4 ± 10.4) mmHg vs.(93.2 ± 6.3),(79.2 ± 7.2) mmHg;daytime:(148.9 ± 9.7),(128.3 ± 10.5) mmHg vs.(96.8 ±6.1),(82.2 ±7.5) mmHg;nighttime:(133.9 ± 11.9),(115.9 ± 12.0) mmHg vs.(85.7 ± 8.0),(72.5 ± 7.5) mmHg),and there was significant difference (t =8.06,8.74,8.00,8.82,5.75,and 6.57 respectively; P < 0.01).T/P ratios of SBP/DBP calculated by overall method were 78.4% (17.4/22.2) and 61.2% (9.0/14.7),but it were (79.3 ±0.4) % and (58.5 ±0.5) % by individual calculation method.(2) Among 30 patients with better effect,the SBP,DBP of the whole-day,daytime and nighttime after treatment were decreased compared to before treatment (the whole day:(143.4 ± 9.1),(127.5 ±10.7) mmHgvs.(92.6 ±6.2),(81.6±7.6) mmHg;daytime:(147.8 ±9.1),(131.0 ±10.5)mmHg vs.(95.8 ± 6.4),(84.1 ± 7.5) mmHg; nighttime:(134.7 ± 11.6),(119.6 ± 13.2) mmHg vs.(86.2 ± 7.4),(75.2 ± 8.5) mmHg),and there was significant difference(t =11.18,12.77,11.14,12.85,7.37,and 8.74 respectively,P <0.01).T/P ratios of SBP/DBP were 78.9% (18.3/23.2),75.3% (11.6/15.4) and SIof SBP/DBP were 7.4(19.5/2.6),7.1 (14.2/2.0) calculated by overall method,but T/P ratios of SBP/DBPwere (78.4 ± 0.4) %,(74.6 ± 0.4) % and SI were (1.35 ± 0.73),(1.34 ± 0.54) calculated by individualmethod.Conclusion Nebivolol (5 mg once daily) can significantly reduce ambulatory blood pressure.Overall calculation method is better than individual method in terms of assessing the time of durative action and smooth effect by trough peak ratio and smooth index.%目的 应用动态血压监测不同方法评价盐酸奈必洛尔治疗轻、中度原发性高血压(EH)的有效性.方法 经过2周安慰剂导入期,47例轻、中度EH受试者进入开放动态血压研究.受试者接受盐酸奈必洛尔片5 mg/d口服,共12周.清洗期末和12周治疗期末进行24 h动态血压测量,对可评估疗效受试者和治疗有效受试者应用整体法和个体法计算谷峰比值和平滑指数.结果 (1)可评估疗效的受试者42例,全天收缩压、舒张压分别为(144.1±9.8)、(124.4±10.4) mmHg,(93.2±6.3)、(79.2±7.2) mmHg;白天收缩压、舒张压分别为(148.9 ±9.7)、(128.3±10.5) mmHg,(96.8±6.1)、(82.2±7.5) mmHg;夜间收缩压、舒张压分别为(133.9±11.9)、(115.9±12.0) mmHg,(85.7±8.0)、(72.5±7.5) mmHg,治疗前后比较差异均有统计学意义(t值分别为8.06、8.74,8.00、8.82,5.75、6.57,P均<0.01);整体法计算收缩压、舒张压的谷峰比值为78.4%(17.4/22.2)、61.2% (9.0/14.7),个体法计算收缩压、舒张压的谷峰比值为(79.3±0.4)%、(58.5±0.5)%.(2)治疗有效的受试者30例,全天收缩压、舒张压分别为(143.4±9.1)、(127.5±10.7) mmHg,(92.6±6.2)、(81.6±7.6) mmHg;白天收缩压、舒张压分别为(147.8±9.1)、(131.0±10.5) mmHg,(95.8±6.4)、(84.1±7.5) mmHg;夜间收缩压、舒张压分别为(134.7±11.6)、(119.6±13.2) mmHg,(86.2±7.4)、(75.2±8.5) mmHg,治疗前后比较差异均有统计学意义(t值分别为11.18、12.77,11.14、12.85,7.37、8.74,P均<0.01);整体法计算收缩压、舒张压的谷峰比值为78.9%(18.3/23.2)、75.3% (11.6/15.4),收缩压、舒张压的平滑指数为7.4 (19.5/2.6)、7.1(14.2/2.0);个体法计算收缩压、舒张压的谷峰比值为(78.4±0.4)%、(74.6±0.4)%,收缩压、舒张压的平滑指数为1.35±0.73、1.34±0.54.结论 盐酸奈必洛尔5 mg每天1次服用能显著降低全天收缩压和舒张压.应用整体法计算治疗有效受试者的谷峰比值和平滑指数比个体法可更合理地评价药物降压作用的维持时间和平稳性.
    • 毛洪宾
    • 摘要: 目的:探讨非洛地平缓释片治疗老年原发性高血压的临床疗效。方法对31例老年轻-中度高血压患者口服非洛地平缓释片5mg/d,疗程8w,行治疗前、后24h动态血压监测(APBM)并计算药物的谷峰比值(T/P)。结果用药1疗程后APBM的24h平均血压、昼间平均血压、夜间平均血压与治疗前相比的差异均有统计学意义(P<0.05),收缩压T/P值为0.72,舒张压T/P值为0.74。未见严重药物不良反应。结论非洛地平缓释片治疗老年轻-中度高血压的效果较好,药效平稳,用药安全。
    • 卢进
    • 摘要: 目的:探究福辛普利对高血压病临床治疗效果。方法选取我部2012年6月到2013年5月诊治的高血压(轻、中度)病例56例,随机将其分为观察和对照组,对观察组的28例患者使用福辛普利,而对照组28例患者则给予硝苯地平缓释片治疗。观察对比分析两组的血压变化和治疗效果。结果治疗后,对照组和观察组病例的收缩压和舒张压均有较明显的降低,两组的临床总有效率相差不大,不存在统计学意义(P>0.05);但是两者的谷峰比差异较大,具有统计学意义(P<0.05)。结论福辛普利治疗高血压病与硝苯地平缓释片对比,在谷峰比值、降压作用平稳持久、用药便捷、副作用少等方面优势明显。
    • 李静; 费心学; 林文波; 夏鹏飞; 胡倩倩; 高壬奎
    • 摘要: OBJECTIVE To investigate the treatment of senile hypertension trough to peak ratio and smoothness index with aspritic acid amlodipin.METHODS 83 cases of senile hypertension patients,oral administration of aspritic acid amlodipin 5-10 mg,once a day,treatment 8 weeks,24 h ambulatory blood pressure monitoring (ABPM) in before and after treatment and calculate T/P ratio and smoothness index.RESULTS After 8 weeks,24 h SBP,dSBP,nSBP and dSBPload,and nSBPload all have significant difference (P<0.05),T/P rates were 74% ;24 h DBP,dDBP,and nDBP comparisons do not obvious differences,there are no statistically significant (P>0.05),DBP after treatment (T/P) were 21%,smoothness index:1.43 ± 0.77systolic blood pressure,diastolic pressure of 1.28 ± 0.54.CONCLUSION Aspritic acid amlodipin treatment of elderly hypertensive trough to peak ratio (T/P) and smoothness index is good on hypertension in the elderly with good effect.%目的:探讨门冬氨酸氨氯地平治疗老年高血压的谷峰比值和平滑指数.方法:对83例老年高血压患者,口服门冬氨酸氨氯地平5~10 mg,每天1次,疗程8周,于治疗前、后进行24 h动态血压监测,计算其谷峰比值(T/P)和平滑指数.结果:治疗8周后,24 h SBP、dSBP、nSBP和dSBPload以及nSBPload的比较均有显著性差异(P<0.05),T/P为74%;24 hDBP、dDBP、和nDBP的比较均无明显差异,没有统计学意义(P>0.05),治疗后DBP的T/P为21%,平滑指数为:收缩压1.43±0.77,舒张压1.28±0.54.结论:门冬氨酸氨氯地平治疗老年高血压谷峰比值及平滑指数均良好,对老年高血压具有良好的降压效果.
    • 荆珊; 陈源源; 孙宁玲; 柯元南; 赵秀丽; 羊镇宇; 华琦; 张国刚; 赵水平
    • 摘要: 目的 评价盐酸奈必洛尔片治疗轻、中度原发性高血压的有效性和安全性,同时评价奈必洛尔的降压平稳性.方法 用多中心、随机、双盲、阳性药物平行对照设计.经过2周安慰剂导入期,入选315例轻中度高血压受试者,随机分为盐酸奈必洛尔片5 mg ·d-1组(试验组)和富马酸比索洛尔片5mg· d-1组(对照组).47例受试者进入开放动态血压研究,服用盐酸奈必洛尔片5 mg·d-1,用药前和用药12周后分别行24 h动态血压监测,计算用药前后24 h收缩压和舒张压的谷峰比值.结果 治疗12周后,2组受试者的平均坐位舒张压及收缩压较基线有显著下降,2组降压有效率分别为73.4%和69.7% (P >0.05).动态血压监测治疗后24 h平均收缩压/舒张压、白天及夜间平均收缩压/舒张压与治疗前比较均显著降低,差异有统计学意义(P<0.01);整体法收缩压谷/峰比为78.9%,舒张压谷/峰比为75.3%.2组间不良事件发生率差异无统计学意义(P>0.05).结论 盐酸奈必洛尔能显著降低舒张压和收缩压,其降压作用持续、平稳,其安全性和耐受性良好.%Objective To evaluate the efficacy, safety and the smooth control effect of nebivolol in mild to moderate essential hypertensive patients. Methods A multicenter, randomized, double - blind, active parallel control design study enrolled 315 subjects with mild to moderate essential hypertension. After 2 weeks of placebo run - in period, subjects were randomized to nebivolol 5 mg daily or bisoprolol 5 mg daily, who were treated with for 12 weeks. 24 h ambulatory blood pressure monitoring after and before treatment were taken and T/P radio were counted with 47 subjects. Results Compared with baseline, mean sitting dias-tolic blood pressure ( MSDBP) and systolic blood pressure ( MSSBP) of the two groups were reduced significantly after 12 weeks. The total efficacy rate of nebivolol group was 73. 4% and the total efficacy rate of bisoprolol group was 69. 7%. There were no differences on the decrease of blood pressure and the total efficacy rate between two groups. The rate of drug related adverse event was similar between two groups (P > 0. 05). Twelve weeks after treatment, compared with baseline, 24 hours systolic/ diastolic blood pressure, day systolic/ diastolic blood pressure and night systolic/ diastolic blood pressure have very significantly differences (P < 0. 01 ) , T/P of systolic blood pressure was 78. 9% , T/P of diastolic blood pressure was 75. 3%. Conclusion Nebivolol can reduce systolic and diastolic blood pressure effectively and has smoothly control effect. Nebivolol is well tolerated and has better safety.
    • 姜红; 王晓莉; 秦廷莉; 柯元南
    • 摘要: 目的:应用动态血压监测进行轻、中度原发性高血压患者每日口服盐酸贝尼地平2~4mg的持续性降压疗效研究.方法:20例轻、中度原发性高血压患者经安慰剂1片/d洗脱2周,若诊室舒张压95~109mmHg且24h平均舒张压≥85mmHg,患者接受贝尼地平2mg/d治疗,如舒张压90mmHg或下降>20 mmHg,则维持原剂量不变,否则递增剂量至4mg/d,治疗8周后进行动态血压监测.另选36例治疗8周且降压有效的患者继续维持原剂量治疗24周.结果:20例患者贝尼地平2~4mg/d治疗后动态血压监测表明,24h动态收缩压/舒张压均值由135.67±6.52/87.30±5.81 mmHg降至126.24±7.34/83.35±5.59mmHg,24h、日间和夜间治疗前后差异显著(P<0.01和P<0.05).36例患者治疗24周,诊室收缩压/舒张压由153.06±13.09/98.89±3.65mmHg降低至133.27±12.70/83.69±6.0mmHg(P<0.01),降压总有效率为88.9%.贝尼地平片主要不良反应有轻度头痛、心慌、浮肿、瘙痒等.结论:每日口服贝尼地平2~4mg可持久、平稳地降低轻、中度原发性高血压患者的血压水平.
    • 陈艳梅; 武云涛; 曹丹阳; 裴志勇; 冬兰; 姚依群
    • 摘要: 目的 探讨老年患者动态血压变化与左心室舒张功能的关系.方法 选择2010年1月至2012年10月在北京军区总医院住院体检的患者586例.所有患者进行24 h动态血压监测,记录血压测定值,并计算平均收缩压、舒张压及谷峰比值.心脏彩色多普勒超声检测心脏收缩和舒张功能.测量二尖瓣舒张早期血流峰值速度(E峰)、舒张晚期血流峰值速度(A峰),并计算E/A比值,分为心功能正常组(n=200):E/A≥1;舒张性心力衰竭组(n=386),E/A<1;分析患者血压及相关指标与左心室舒张功能的关系.结果 舒张性心力衰竭组有78.8%患者发生高血压病、65.3%发生冠状动脉粥样硬化性心脏病(冠心病)、48.7%发生脑梗死,发病率分别高于舒张功能正常组的70%、39%、57.4%,差异均有统计学意义(P<0.05);糖尿病的发生无明显差异.多重线性回归分析显示,舒张功能与年龄(β=0.861)负相关,与收缩压谷峰比值(β=0.200)正相关与平均舒张压(β=-0.411)负相关(均P<0.05).结论 舒张性心力衰竭与高血压病、冠心病、脑梗死密切相关,与血压谷峰比值、低舒张压密切相关,对老年这一特殊人群的高血压,控制高血压预防靶器官损伤应重视血压的总体波动水平及关注低舒张压.
    • 李云逸; 陈维生; 于锋
    • 摘要: 目的比较阿折地平片与苯磺酸氨氯地平片治疗轻、中度原发性高血压的临床疗效。方法随机双盲将64例轻、中度高血压患者分为苯磺酸氨氯地平片组(A组)和阿折地平片组(B组),经过2周清洗期后,分别给予苯磺酸氨氯地平片5mg、阿折地平片8mg口服治疗,每天1次,疗程均为8周。在用药前和用药8周时进行24h动态血压监测,比较2组的动态血压变化和谷峰比值。结果 2组患者用药8周后24h平均收缩压和舒张压(24hSBP/DBP)、日间平均收缩压和舒张压(dSBP/DBP)、夜间平均收缩压和舒张压(nSBP/DBP)较用药前显著降低,差异均有统计学意义(P0.05)。2组的降压谷峰比值均>50%。结论阿折地平片与苯磺酸氨氯地平片对轻、中度高血压均有良好的疗效,且均具有持续、稳定的降压效果。
  • 查看更多

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号