Digital

摘要： Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic agents.However,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel processing.Here,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug development.Up to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick response.Our platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo study.In addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/mL.The successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer.

摘要： Teleradiology plays a vital role in the medical field,which permits transmitting medical and imaging data over a communication network.It ensures data reliability and provides convenient communication for clinical interpretation and diagnostic purposes.The transmission of this medical data over a network raises the problems of legal,ethical issues,privacy,and copyright authenticity.The copyright protection of medical images is a significant issue in the medical field.Watermarking schemes are used to address these issues.A gray-level or binary image is used as a watermark frequently in color image watermarking schemes.In this paper,the authors propose a novel non-blind medical image watermarking scheme based on 2-D LiftingWavelet Transform(LWT),Multiresolution Singular Value Decomposition(MSVD),and LU factorization to improve the robustness and authenticity of medical images.In this scheme,multiple color watermarks are embedded into the colored DICOM(Digital Imaging and Communications inMedicine)images obtained from Color Doppler images(DICOM format),and the average results achieved by our proposed scheme is 46.84 db for Peak Signal-to-Noise Ratio(PSNR),37.46 db for Signal-to-Noise Ratio(SNR),0.99 for Quality of Image and 0.998 for Normalized Correlation for various image processing attacks.These results make our watermarking technique an ideal candidate for medical image watermarking.

摘要： BACKGROUND An extra tooth in the normal tooth sequence in any region of the dental arch is regarded as a supernumerary tooth(SNT).Due to the large variation in location and morphology,the extraction of impacted SNTs is an extensive and complex procedure with high risks of several complications.This report presents a rare case of seven impacted SNTs in the bilateral upper and lower arch that were successfully extracted with the use of digital positioning guide plates.CASE SUMMARY In January 2022,a 21-year-old male was referred to our department with a chief complaint of pain in relation to tooth#36.Clinical examination showed a deep carious lesion with pulpal involvement in tooth#36 and lingual swelling of the bilateral mandibular posterior area.Radiographic examination revealed seven deeply impacted SNTs in the bilateral posterior area and bilateral impacted mandibular third molars.Based on these findings,the patient was diagnosed with bilateral,multiple impacted SNTs and tooth#36 chronic pulpitis.A root canal treatment and an all-ceramic crown restoration for tooth#36 were performed.An individualized digital positioning guide plate was designed by computer-aided design/computer-aided manufacturing technology and cone-beam computed tomography for extraction of the impacted SNTs.During the operation,the digital positioning guide plate allowed rapid positioning and exposure of the SNTs while avoiding adjacent important anatomical structures.At 3-month follow-up,regeneration of bone and soft tissues was visible.CONCLUSION The application of digital positioning guide plates is useful for the individualized and minimalized extraction of impacted supernumerary teeth.

摘要： Dear editor,Metasurfaces have been proposed and investigated in the past years owing to their unique advantages in controlling electromagnetic(EM)waves.By adjusting the phase and amplitude of EM waves,we can achieve the desired functions based on metasurfaces[1].In 2014,the digital coding metasurfaces were proposed by Cui et al.[2].

摘要： The usage of full-color imaging in digital pathology produces significant results.Compared with a grayscale image or a pseudocolor image containing contrast information,a full-color image can identify and detect the target object better with color texture information.Fourier ptychographic microscopy(FPM)is a high-throughput computational imaging technique that breaks the tradeoff between high resolution(HR)and a large field of view.It also eliminates the artifacts of scanning and stitching in digital pathology and improves its imaging efficiency.However,the conventional full-color digital pathology based on FPM is still time-consuming because of the repeated experiments with tri-wavelengths.A color transfer FPM approach termed“CFPM”was reported.The color texture information of a low-resolution full-color pathologic image is directly transferred to the HR grayscale FPM image captured by only a single wavelength.Both of the color space of FPM based on the standard CIE-XYZ color model and the display based on the standard RGB color space were established.Different FPM colorization schemes were analyzed and compared with 30 biological samples.Three types of evaluation approaches were provided,including the root-mean-square error(RMSE),the difference maps,and the image histogram cosine similarity.The average RMSE values of the conventional method and CFPM compared with the ground truth were 5.3%and 5.7%,respectively.Therefore,the reconstruction time is significantly reduced by 2/3 with the sacrifice of precision of only 0.4%.The CFPM method is also compatible with advanced fast FPM approaches to further reduce computation time.

摘要： Several capture techniques are used in intraoral optical scanners in the dental market,such as Triangulation(Cerec Omnicam,Dentsply Sirona),Activewave front sampling(3M ESPE)and confocal technology(iTero,Align).The accuracy of intraoral scanners is the most significant focal point for developers to research.This in-vitro study studied the accuracy of confocal scanners launched from 2015-2020(Trios 3,Trios 4,iTero Element;3Shape Trios A/S,Copenhagen,Denmark,and iTero Element2,and iTero Element5D;Align Technologies,San Jose,CA,USA).A 3D printing model modified from the American National Standard No.132 was scanned five times each scanner.Both Trios3 and Trios4 were scanned using regular scan mode(N)and high-resolution mode(HR).All scanning methods followed the recommendations from the manufacturers.Then the digital models were exported and saved as STL files.Various measurements were determined in the digital model from each scan using Rhinoceros 3D Software(Rhino,Robert McNeel&Associates for Windows,Washington DC,USA).Measurements from the 3D printed model were used as control.All data were recorded in Microsoft Excel and then transferred to SPSS.Descriptive statistics were recorded.Multiple comparisons of various measurements were made among the different scanners and with the control using One-way ANOVA and post hoc using Sheffe(p<0.01).The surface area in the X and Y axis ranged from 2–60 mm,while the depth(Z-axis)ranged from 2–8 mm.The Trios and iTero families showed similar accuracy.However,for the diagonal,the Trios series showed better results compared with the iTero series.Within the same brand,different versions showed no significant change regarding accuracy.

摘要： Dear editor,With the rapid development of digital currencies and blockchain technologies,an increasing number of countries are planning to launch or have already launched their own central bank-issued digital currency(CBDC).

摘要： Since opening of the Korean high-speed railway in 2004,the rate of electrification has been increasing rapidly,and safety of the supply of AC railways has become very important.And the digital protection relays in railway feeding system need more attention with the expansion of unmanned SSs(substations)and digital SSs.For accident prevention,it is necessary to develop accurate modeling and simulation technology for railway feeding devices of electric railway.And it is also important to continuously improve test methods and develop excellent relay algorithms and apply them to the protection system to prepare for unexpected accidents.In this study,after reduced modeling the AC railway power supply system using PSCAD/EMTDC(Power Systems Computer Aided Design/Electromagnetic Transient DC Analysis),the results were compared and verified with the numerical calculation using the symmetric coordinate method.It also presents a method of using the verified results for simulation and education for various railway accidents.This study result will be used for the construction of new lines as well as existing lines in the future railway business.

摘要： Artificial intelligence(AI)has grown tremendously in the last decades and is undoubtedly the future era in medicine.Concerning digestive diseases,applications of AI include clinical gastroenterology,gastrointestinal endoscopy and imaging,and not least pathological diagnosis.Several gastrointestinal pathologies require histological confirmation for a positive diagnosis.Among them,celiac disease(CD)diagnosis has been in the spotlight over time,but controversy is still ongoing with regard to the so-called celiac-type histology.Despite efforts to improve histological diagnosis in CD,there are still several issues and pitfalls associated with duodenal histology reading.Several papers have assessed the accuracy of AI techniques in detecting CD on duodenal biopsy images and have shown high diagnostic performance over standard histology reading.We discuss the role of computer-assisted histology in improving the assessment of mucosal architectural injury and inflammation in CD patients,both for diagnosis and follow-up.

摘要： 本发明涉及一种新型的汽车音频Digital Chime播放器，属于汽车电子技术领域，包括MCU、DSP、第一Flash、第二Flash，MCU接DSP、第一Flash，DSP接第一、第二Flash；初始化时，DSP为主机，第二Flash为从机，第二Flash的HiFi处理程序加载入DSP的HiFi内核中，初始化后，切断DSP和第二Flash之间的通信，DSP将SPI数据通道挂载到MCU和第一Flash之间的SPI数据通道上，MCU为主机，第一Flash为从机，DSP从主机切换为从机，实现双从机数据传输。本播放器可有效提高Chime的音质，可自由定制多样化音效，克服了对特定DSP芯片模块的依赖。

摘要： 本发明属于检验检疫技术领域，具体涉及一种检测非洲猪瘟病毒的引物探针组合及基于微流控芯片Digital PCR的检测方法。所述引物探针组合中引物对的核酸序列如SEQ ID NO.1~2所示，所述引物探针组合中探针的核酸序列如SEQ ID NO.3所示。所述引物探针组合用于扩增非洲猪瘟病毒的B646L基因的保守序列，所述保守序列具体如SEQ ID NO.4所示。当利用该引物探针组合进行基于微流控芯片Digital PCR时，对非洲猪瘟病毒的最低检测限可以低至每微升模板30.1995 copies，且Digital PCR具有很好的重复性，其平均CV值为9.56%。

摘要： 本发明涉及一种新型的汽车音频Digital Chime播放器，属于汽车电子技术领域，包括MCU、DSP、第一Flash、第二Flash，MCU接DSP、第一Flash，DSP接第一、第二Flash；初始化时，DSP为主机，第二Flash为从机，第二Flash的HiFi处理程序加载入DSP的HiFi内核中，初始化后，切断DSP和第二Flash之间的通信，DSP将SPI数据通道挂载到MCU和第一Flash之间的SPI数据通道上，MCU为主机，第一Flash为从机，DSP从主机切换为从机，实现双从机数据传输。本播放器可有效提高Chime的音质，可自由定制多样化音效，克服了对特定DSP芯片模块的依赖。

摘要： 本发明涉及数字孪生技术领域，且公开了meta‑digital数字孪生存储云发布平台，包括中央处理器，所述中央处理器的内部包括有录入单元、辅助单元、发布单元，所述录入单元包括输入模块、识别模块一、检测模块，所述输入模块的信号输出端与识别模块一的信号接收端连接，所述识别模块一的信号输出端与检测模块的信号接收端连接通过设置中央处理器，使得在进行刻画物理实体过程中的各个步骤能够得到有效统筹，使得刻画过程更加流畅，从而提高刻画的速度，通过设置录入单元，通过输入模块对物品进行三维数据测量之后，对测量出的数据进行录入，通过识别模块一对录入的数据进行识别，通过检测模块对录入的数据进行拼写检查，从而保证录入数据的正确性。