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Depression

Depression的相关文献在1993年到2023年内共计567篇,主要集中在肿瘤学、神经病学与精神病学、内科学 等领域,其中期刊论文566篇、会议论文1篇、相关期刊140种,包括中国药理学与毒理学杂志、中国科学、世界胃肠病学杂志:英文版等; 相关会议1种,包括中华预防医学会精神卫生分会成立大会暨第一次学术交流会议等;Depression的相关文献由2462位作者贡献,包括Abdelhalem Mesfioui、Ali Ouichou、Aboubaker El Hessni等。

Depression—发文量

期刊论文>

论文:566 占比:99.82%

会议论文>

论文:1 占比:0.18%

总计:567篇

Depression—发文趋势图

Depression

-研究学者

  • Abdelhalem Mesfioui
  • Ali Ouichou
  • Aboubaker El Hessni
  • DENG Xiaolin
  • Elisabeth Severinsson
  • Gabriele Sani
  • Giuseppe Marano
  • James R. Hall
  • Lei Xu
  • Marianna Mazza
  • 期刊论文
  • 会议论文

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    • Qiang Su; Tian Li; Guo-Wei Liu; Yan-Li Zhang; Jun-Hong Guo; Zhao-Jun Wang; Mei-Na Wu; Jin-Shun Qi
    • 摘要: Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B(MT/MT)and antagonist of 5-hydroxytryptamine 2C receptors.It is used clinically to treat major depressive episodes in adults.The pro-chronobiological activity of agomelatine reconstructs sleep-wake rhythms and normalizes circadian disturbances via its agonistic effect of melatonin receptor 1A/melatonin receptor 1B,which work simultaneously to counteract depression and anxiety disorder.Moreover,by antagonizing neocortical postsynaptic 5-hydroxytryptamine 2C receptors,agomelatine enhances the release of dopamine and noradrenaline in the prefrontal cortex,increases the activity of dopamine and noradrenaline,and thereby reduces depression and anxiety disorder.The combination of these two effects means that agomelatine exhibits a unique pharmacological role in the treatment of depression,anxiety,and disturbance of the circadian rhythm.Emotion and sleep are closely related to memory and cognitive function.Memory disorder is defined as any forms of memory abnormality,which is typically evident in a broad range of neurodegenerative diseases,including Alzheimer’s disease.Memory impairment and cognitive impairment are common symptoms of neurodegenerative and psychiatric diseases.Therefore,whether agomelatine can improve memory and cognitive behaviors if used for alleviating depression and circadian-rhythm sleep disorders has become a research“hotspot”.This review presents the latest findings on the effects of agomelatine in the treatment of psychologic and circadian-rhythm sleep disorders in clinical trials and animal experiments.Our review evaluates recent studies on treatment of memory impairment and cognitive impairment in neurodegenerative and psychiatric diseases.
    • Grace A Porter; Jason C O’Connor
    • 摘要: Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction.
    • Jianbo Xiu; Lanlan Li; Qi Xu
    • 摘要: Objective To examine the neuroanatomical substrates underlying the effects of minocycline in alleviating lipopolysaccharide(LPS)-induced neuroinflammation.Methods Forty C57BL/6 male mice were randomly and equally divided into eight groups.Over three conse-cutive days,saline was administered to four groups of mice and minocycline to the other four groups.Immediately after the administration of saline or minocycline on the third day,two groups of mice were additionally injected with saline and the other two groups were injected with LPS.Six or 24 hours after the last injection,mice were sacrificed and the brains were removed.Immunohistochemical staining across the whole brain was performed to detect microglia activation via Iba1 and neuronal activation via c-Fos.Morphology of microglia and the number of c-Fo-positive neurons were analyzed by Image-Pro Premier 3D.One-way ANOVA and Fisher’s least-significant differences were employed for statistical analyses.Results Minocycline alleviated LPS-induced neuroinflammation as evidenced by reduced activation of microglia in multiple brain regions,including the shell part of the nucleus accumbens(Acbs),paraventricular nucleus(PVN)of the hypothalamus,central nucleus of the amygdala(CeA),locus coeruleus(LC),and nucleus tractus solitarius(NTS).Minocycline significantly increased the number of c-Fo-positive neurons in NTS and area postrema(AP)after LPS treatment.Furthermore,in NTS-associated brain areas,including LC,lateral parabrachial nucleus(LPB),periaqueductal gray(PAG),dorsal raphe nucleus(DR),amygdala,PVN,and bed nucleus of the stria terminali(BNST),minocycline also significantly increased the number of c-Fo-positive neurons after LPS administration.Conclusion Minocycline alleviates LPS-induced neuroinflammation in multiple brain regions,possibly due to increased activation of neurons in the NTS-associated network.
    • Si-Sheng Huang
    • 摘要: As elderly people increasingly come to represent a higher proportion of the world’s population,various forms of dementia are becoming a significant chronic disease burden.The World Health Organization emphasizes dementia care as a public health priority and calls for more support for family caregivers who commonly play a significant,central role in dementia care.Taking care of someone with dementia is a long-term responsibility that can be stressful and may lead to depression among family caregivers.Depression and related behavioral and cognitive changes among caregivers could in turn affect the status and prognosis of the dementia patient.This review article explores depression in dementia caregivers and summarizes proposed mechanisms,associated factors,management and research findings,and proposes future research directions.
    • Jingxia Lin; Tianhao Chen; Jiali He; Raymond CK Chung; Haixia Ma; HWH Tsang
    • 摘要: BACKGROUND Depression is recognized as a major public health problem with a substantial impact on individuals and society.Complementary therapies such as acupressure may be considered a safe and cost-effective treatment for people with depression.An increasing body of research has been undertaken to assess the effectiveness of acupressure in various populations with depression,but the evidence thus far is inconclusive.AIM To examine the efficacy of acupressure on depression.METHODS A systematic literature search was performed on PubMed,PsycINFO,Scopus,Embase,MEDLINE,and China National Knowledge(CNKI).Randomized clinical trials(RCTs)or single-group trials in which acupressure was compared with control methods or baseline in people with depression were included.Data were synthesized using a random-effects or a fixed-effects model to analyze the impacts of acupressure treatment on depression and anxiety in people with depression.The primary outcome measures were set for depression symptoms.Subgroups were created,and meta-regression analyses were performed to explore which factors are relevant to the greater or lesser effects of treating symptoms.RESULTS A total of 14 RCTs(1439 participants)were identified.Analysis of the betweengroup showed that acupressure was effective in reducing depression[Standardized mean differences(SMDs)=-0.58,95%CI:-0.85 to-0.32,P<0.0001]and anxiety(SMD=-0.67,95%Cl:-0.99 to-0.36,P<0.0001)in participants with mildto-moderate primary and secondary depression.Subgroup analyses suggested that acupressure significantly reduced depressive symptoms compared with different controlled conditions and in participants with different ages,clinical conditions,and duration of intervention.Adverse events,including hypotension,dizziness,palpitation,and headache,were reported in one study.CONCLUSION The evidence of acupressure for mild-to-moderate depressive symptoms was significant.Importantly,the findings should be interpreted with caution due to study limitations.Future research with a well-designed mixed method is required to consolidate the conclusion and provide an in-depth understanding of potential mechanisms underlying the effects.
    • James M. Gregory
    • 摘要: A mathematical model has been developed to numerically model the risk of developing Alzheimer’s disease and Chronic Traumatic Encephalopathy (CTE) as a person ages. The model was programmed in Excel to provide a working prototype computer simulation model. The model provides estimates of the cumulative risk of developing Alzheimer’s disease and CTE as age increases. A one-year step size was used. The model has two major parts: one predicts changes in slow-wave sleep as a person ages and the second component adjusts the flushing efficiency of waste products from the brain. The two components work together and interact to lower the flushing of waste components as age increases. The development of the model provides an overview of how the various factors work together that lead to the onset of Alzheimer’s disease and the associated CTE. Calibration of the coefficients in the model is based on published data sets presented in the literature. Further research and refinement of calibration coefficients should be explored.
    • Yaxin WANG; Shanshan GUO; Yingjie GAO; Ya TU; Xiaolan CUI
    • 摘要: [Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.
    • Xue-E Fang; Dan-Ping Chen; Ling-Ling Tang; Yan-Jun Mao
    • 摘要: BACKGROUND Depression has been reported to be prevalent in patients with pulmonary tuberculosis(PTB).Moreover,several clinical symptoms of PTB and depression overlap,such as loss of appetite and malnutrition.However,the association between depression and malnutrition in TB patients has not been fully elucidated.AIM To explore the association between depression and malnutrition in patients with PTB.METHODS This hospital-based cross-sectional study included patients with PTB in Shanghai Pulmonary Hospital Affiliated to Tongji University from April 2019 to July 2019.The Patient Health Questionnaire-9(PHQ-9)scale was used to evaluate depression.The cut-off value was set at 10,and the nutritional state was determined by the body mass index(BMI).In addition,the Quality of Life Instruments for Chronic Diseases was employed to establish the quality of life(QOL).Univariable analysis and multivariable analysis(forward mode)were implemented to identify the independent factors associated with depression.RESULTS A total of 328 PTB patients were screened for analysis.Eight were excluded for missing demographic data,four excluded for missing nutrition status,and sixteen for missing QOL data.Finally,300 PTB patients were subjected to analysis.We found that depressive state was present in 225 PTB patients(75%).The ratio of malnutrition in the depressive PTB patients was 45.33%.Our results revealed significantly lower BMI,hemoglobin,and prealbumin in the depression group than in the control group(P<0.05).Moreover,the social status differed significantly(P<0.05)between the groups.In addition,glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in the depression group were significantly higher than those in the control group(P<0.05).Multivariable logistic regression analysis showed that BMI[odds ratio(OR)=1.21,95%confidence interval(CI):1.163-1.257,P<0.001]and poor social function(OR=0.95,95%CI:0.926-0.974,P=0.038)were independently associated with depression.CONCLUSION Malnutrition and poor social function are significantly associated with depressive symptoms in PTB patients.A prospective large-scale study is needed to confirm these findings.
    • Shu Wang; Yu-Guang Guan; Yan-Hua Zhu; Min-Zhong Wang
    • 摘要: As a common and serious psychiatric disorder,depression significantly affects psychosocial functioning and quality of life.However,the mechanism of depression is still enigmatic and perplexing,which limits its precise and effective therapeutic methods.Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression.In this respect,high mobility group box 1(HMGB1)may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for depression.Herein,we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic.
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