摘要：
目的 了解Eales病患者血清中PR3一ANCA和MPO-ANCA的含量,以及其在诊断和治疗中的意义.方法 临床对照研究.于2009～2014年在解放军总医院眼科详细记录每份血清的患者所在分期,应用间接免疫荧光(IIF)法检测ANCA总抗体,用ELISA法检测抗PR3抗体和抗MPO抗体.结果 PR3抗体指标:首发组阳性率为54.3％ (19/35),对照组阳性率为0,显著高于对照组,治愈组阳性率为11.5％ (3/26),与对照组相比无明显统计学差异,治愈组阳性率显著低于首发组.MPO抗体:首发组阳性率为22.9％ (8/35),对照组阳性率为0,显著高于对照组,治愈组阳性率为3.8％ (3/26),首发组和治愈组之间无显著性差异.在Eales病分期的四个期,抗PR3抗体阳性率分别为50％ (2/4),60％ (6/10),66.7％ (10/15)和16.7％ (1/6).结论 ANCA在Eales病的诊断中具有肯定意义,有望成为Eales病诊断以及评价治疗效果的一个血清学标志.同时检测MPO抗体和PR3抗体诊断意义更大.%Objective To learn Eales disease patients in a PR3 ANCA and MPO-ANCA of content, and its significance in the diagnosis and treatment of Eales disease.Methods Detailed records of each serum where staging, indirect immunofluorescence (IIF) assay ANCA total antibody to detect anti-PR3 antibody and anti-MPO antibodies by ELISA.Results From PR3 antibody indicators, positive first group was 54.3％, significantly higher.The positive rate of 11.5％ cure, no significant difference compared with the control group.The positive rate of cure was significantly lower than the first group.MPO antibodies from the point of view, the first group the positive rate of 22.9％, significantly higher.But there was no significant difference between the first group and the cure group.With the new staging system, four of the Eales disease was seen, anti-PR3 antibody positive rates were 50％, 60％, 66.7％ and 16.7％.Conclusions ANCA has affirmed in the diagnosis of Eales disease, there is hope to become Eales disease diagnosis as well as a serological marker to assess treatment effects.From clinical practice, detecting MPO antibodies and PR3 antibody is first choice.
