摘要：
Objective To explore the correlation between the level of serum matrix metalloproteinase-9(MMP-9)and artery elasticity function in diabetic patients.Methods Thirty healthy volunteers were selected as normal control group,71 diabetic patients were enrolled and divided into two groups:31 diabetic patients with normal thickness of carotid artery intima(normal intima group),40 diabetic patients with thickened intima or atheromatous plaque formation(endometrial change group).The level of MMP-9 were measured by enzyme linked immunosorbent assay.The blood vessel elastic modulus,including carotid arterial stiffness(β),pressure-strain elastic modulus(Eρ),arterial compliance(AC),increase index(AI)and pulse wave conduction velocity(PWVβ)were calculated by echo-tracking technique(ET).Then the correlation between serum MMP-9 level and carotid artery elasticity parameters were analyzed.Results The value of Eρ,AI,PWVβ and the level of serum MMP-9 in normal intima group were higher than those in normal control group,while AC was lower than that in normal control group(all P<0.05).The value of β,Eρ,AI,PWVβ and the level of serum MMP-9 in endometrial change group were higher than those in normal control group, while AC was lower than that in normal control group(all P<0.05).The value of β,Eρ,PWVβ and the level of serum MMP-9 in endometrial change group were higher than those in normal intima group,while AC was lower than that in normal intima group(all P<0.05).The level of serum MMP-9 was related with Eρ,AC and PWVβ in normal intima group(r=0.375,-0.716,0.405,all P<0.05),and the level of serum MMP-9 was related with Eρ,β and AC in endometrial change group(r=0.616,0.381,-0.484,all P<0.05).Conclusion There is correlation between artery elasticity function and serum MMP-9 level in diabetic patients,the level of MMP-9 can be used as a sensitive index to detect the atherosclerosis in early stage.%目的 探讨糖尿病患者颈动脉弹性指标与血清基质金属蛋白酶-9(MMP-9)水平的相关性.方法 选取糖尿病颈动脉内膜未见明显改变患者31例(内膜正常组)、糖尿病颈动脉内膜增厚及斑块形成患者40例(内膜改变组)及健康志愿者30例(正常对照组),应用酶联免疫吸附试验检测各组血清MMP-9水平,血管回声跟踪(ET)技术检测并比较各组颈动脉僵硬度(β)、压力弹性应变系数(Eρ)、顺应性(AC)、增大指数(AI)及脉搏波传导速度(PWVβ),分析糖尿病患者血清MMP-9水平与颈动脉弹性指标的相关性.结果 与正常对照组比较,内膜正常组Eρ、AI、PWVβ及MMP-9水平均增高,AC降低,差异均有统计学意义(均P<0.05);内膜改变组β、Eρ、AI、PWVβ及MMP-9水平均增高,AC降低,差异均具有统计学意义(均P<0.05).与内膜正常组比较,内膜改变组β、Eρ、PWVβ及MMP-9水平均增高,AC降低,差异均有统计学意义(均P<0.05).内膜正常组血清MMP-9水平与Eρ、AC、PWVβ相关(r=0.375、-0.716、0.405,均P<0.05);内膜改变组血清MMP-9水平与Eρ、β、AC相关(r=0.616、0.381、-0.484,均P<0.05).结论 糖尿病患者颈动脉弹性指标与血清MMP-9水平相关,可作为糖尿病患者早期发现动脉粥样硬化病变的敏感指标.
