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蚕蚀性角膜溃疡

蚕蚀性角膜溃疡的相关文献在1990年到2021年内共计86篇,主要集中在眼科学、临床医学、预防医学、卫生学 等领域,其中期刊论文82篇、会议论文2篇、专利文献455319篇;相关期刊55种,包括世界中医药、现代中西医结合杂志、浙江中医杂志等; 相关会议2种,包括华东地区第13届实验动物科学学术交流会、第七届全国角膜病及眼表疾病学术会议等;蚕蚀性角膜溃疡的相关文献由193位作者贡献,包括陈家祺、周世有、袁进等。

蚕蚀性角膜溃疡—发文量

期刊论文>

论文:82 占比:0.02%

会议论文>

论文:2 占比:0.00%

专利文献>

论文:455319 占比:99.98%

总计:455403篇

蚕蚀性角膜溃疡—发文趋势图

蚕蚀性角膜溃疡

-研究学者

  • 陈家祺
  • 周世有
  • 袁进
  • 史伟云
  • 姜冬玲
  • 张明昌
  • 李冰
  • 李素霞
  • 王青松
  • 胡燕华
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 文丰; 许玲俐; 王骥; 裘婷婷; 施恩; 强薇
    • 摘要: 目的 探讨板层角膜移植联合角膜胶原交联治疗蚕蚀性角膜溃疡的效果.方法 收集18例19眼蚕蚀性角膜溃疡患者,按病灶的形态,用相应大小直径角膜环钻作压痕,尽可能保留视轴区透明角膜,手术切除病灶内坏死角膜组织、巩膜组织,制作植床;根据植床的大小、形态,用穿透性角膜移植术后留下的残片,制作成形态相近的植片;间断缝合植片,刮除距植床边缘约2.0 mm健康角膜上皮,0.1%核黄素滴眼12 min,平衡液冲洗,紫外线18 mW/cm2,照射5min.结果 术前最佳矫正视力(BCVA) (logMAR)为(1.095±0.149),术后6个月BCVA为(0.605±0.093),术后视力明显提高(P<0.05),溃疡复发1例(5.3%),无大泡性角膜炎,无上皮愈合迟缓.结论 板层角膜移植联合角膜胶原交联治疗蚕蚀性角膜溃疡可明显提高患者视力,复发率低,无明显手术并发症.
    • 王珂
    • 摘要: 目的通过观察比较在行板层角膜移植术治疗蚕蚀性角膜溃疡中,分别采用环形板层角膜移植术与全板层角膜移植术,在术后最佳矫正视力、散光度数的不同,探讨在手术治疗蚕蚀性角膜溃疡中,降低板层角膜移植术后散光及排斥反应的方法.方法:本选取24例(24眼)蚕蚀性角膜溃疡患者,分为实验组与对照组各12例12眼,比较两组患者术后4、8个月的最佳矫正视力,探讨在手术治疗蚕蚀性角膜溃疡中,降低板层角膜移植术后散光及排斥反应的方法.结果:(1)术后4个月:最佳矫正视力:实验组平均0.51 , 对照组平均0.39;术后8个月:最佳矫正视力:实验组平均0.52 , 对照组平均0.41.观察组均显著优于对照组(P〈0.05).(2)实验组复发1例,未出现排斥反应;对照组复发3例,出现排斥反应2例.结论:在手术治疗蚕蚀性角膜溃疡中,采用环形板层角膜移植术能够有效减少角膜的不规则散光,尤其是保证了瞳孔区角膜的透亮度,从而视力恢复较好,同时由于植片较小,减少了新生血管的生长,降低了排斥反应,并且节省了角膜植片,有很大的推广前景.
    • 胡艳珺; 林斌武; 陈家祺; 周世有
    • 摘要: 背景 蚕蚀性角膜溃疡是免疫性角膜疾病,治疗效果不佳,其发病机制尚未完全明确.研究表明,外周血CD4+淋巴细胞亚群辅助性T细胞(Th)1型和2型细胞的平衡失调在相关的自身免疫性疾病中发挥作用,但其与蚕蚀性角膜溃疡发生和发展的关系尚不清楚. 目的 比较活动期蚕蚀性角膜溃疡患者外周血Th1和Th2细胞比例的变化. 方法 纳入2012年1月至2013年7月在中山大学中山眼科中心确诊的活动期蚕蚀性角膜溃疡患者11例,同期在同一医院体检的健康职工8人作为对照.抽取受检者外周血10 ml分离外周血单核细胞(PBMCs),用流式细胞仪测定PBMCs中Th细胞亚群的比例;采用实时荧光定量PCR(RT-qPCR)法测定受检者PBMCs中T-bet、GATA-3、信号传导子及转录激活子5(Stat5) mRNA的相对表达量.结果 蚕蚀性角膜溃疡组患者PBMCs中Th1细胞所占CD4+细胞的百分比及Th1/Th2的比值分别为0.21%(0.11%,0.31%)和8.01(4.49,12.01),明显低于正常对照组的0.35% (0.22%,0.71%)和23.90(22.49,33.49),差异均有统计学意义(Z=-2.01,P=0.04;Z=-3.06,P=0.00);蚕蚀性角膜溃疡组患者PBMCs中Th2细胞所占CD4+细胞的百分比为0.02% (0.02%,0.03%),与正常对照组的0.01% (0.01%,0.02%)比较差异无统计学意义(Z=-1.98,P>0.05).与正常对照组比较,蚕蚀性角膜溃疡组患者PBMCs中T-bet mRNA、GATA-3 mRNA的相对表达量明显下降,差异均有统计学意义(Z=-3.47、-3.06,均P=0.00),两个组间Stat5mRNA的相对表达水平差异无统计学意义(Z=-1.05,P=0.33).结论 活动期蚕蚀性角膜溃疡患者外周血Th1及Th2细胞所占的CD4+细胞百分比与相关转录因子的含量均发生明显变化,提示Th1细胞及Th2细胞与蚕蚀性角膜溃疡的发病有关.
    • 胡艳珺; 林斌武; 陈家祺; 周世有
    • 摘要: 背景 蚕蚀性角膜溃疡是免疫性角膜疾病,治疗效果不佳,其发病机制尚未完全明确.研究表明,外周血CD4+淋巴细胞亚群辅助性T细胞(Th)1型和2型细胞的平衡失调在相关的自身免疫性疾病中发挥作用,但其与蚕蚀性角膜溃疡发生和发展的关系尚不清楚. 目的 比较活动期蚕蚀性角膜溃疡患者外周血Th1和Th2细胞比例的变化. 方法 纳入2012年1月至2013年7月在中山大学中山眼科中心确诊的活动期蚕蚀性角膜溃疡患者11例,同期在同一医院体检的健康职工8人作为对照.抽取受检者外周血10 ml分离外周血单核细胞(PBMCs),用流式细胞仪测定PBMCs中Th细胞亚群的比例;采用实时荧光定量PCR(RT-qPCR)法测定受检者PBMCs中T-bet、GATA-3、信号传导子及转录激活子5(Stat5) mRNA的相对表达量.结果 蚕蚀性角膜溃疡组患者PBMCs中Th1细胞所占CD4+细胞的百分比及Th1/Th2的比值分别为0.21%(0.11%,0.31%)和8.01(4.49,12.01),明显低于正常对照组的0.35% (0.22%,0.71%)和23.90(22.49,33.49),差异均有统计学意义(Z=-2.01,P=0.04;Z=-3.06,P=0.00);蚕蚀性角膜溃疡组患者PBMCs中Th2细胞所占CD4+细胞的百分比为0.02% (0.02%,0.03%),与正常对照组的0.01% (0.01%,0.02%)比较差异无统计学意义(Z=-1.98,P>0.05).与正常对照组比较,蚕蚀性角膜溃疡组患者PBMCs中T-bet mRNA、GATA-3 mRNA的相对表达量明显下降,差异均有统计学意义(Z=-3.47、-3.06,均P=0.00),两个组间Stat5mRNA的相对表达水平差异无统计学意义(Z=-1.05,P=0.33).结论 活动期蚕蚀性角膜溃疡患者外周血Th1及Th2细胞所占的CD4+细胞百分比与相关转录因子的含量均发生明显变化,提示Th1细胞及Th2细胞与蚕蚀性角膜溃疡的发病有关.%Background Mooren 's ulcer is an immune-related corneal inflammatory disease,and its pathogenesis remains below understood.Previous studies showed that the imbalance of T helper cell type 1 (Th1) and Th2 cell play important roles in the development of some autoimmune diseases.Thereby the influence of Th1/Th2 cells on the pathogenesis of Mooren's ulcer is being concerned.Objective This study was to investigate the change of Th1 and Th2 subsets in periphery blood of patients with active Mooren's ulcer.Methods Eleven consecutive patients with active Mooren's ulcer and 8 age-and gener-matched healthy controls were included in Zhongshan Ophthalmic Center,Sun Yat-sen University from January 2012 to July 2013 under the approval of Ethic Committee of this hospital and informed consent of each subject.The peripheral blood samples of all the subjects were obtained separately and periphery blood mononuclear cells (PBMCs)were isolated.The percentages of Th1 and Th2 in the PBMCs were assayed by flow cytometer.The relative expressions of T-bet mRNA,GATA-3 mRNA and signal transducer and activator of transcription 5 (Stat5) mRNA in the PBMCs were examined and compared by real-time fluorescence quantitative PCR (RT-qPCR) Results The percentage of Th1 cells in CD4+ T cells and Th1/Th2 value was 0.21% (0.11%,0.31%) and 8.01 (4.49,12.01) respectively in the Mooren's ulcer group,which were significantly lower than 0.35% (0.22%,0.71%)and 23.90 (22.49,33.49)in the normal control group,respectively (Z =-2.01,P =0.04 ; Z =-3.06,P =0.00).However,no significant difference was found in the percentage of Th2 between the two groups (Z=-1.98,P>0.05).The relative expressions of T-bet mRNA and GATA-3 mRNA in PBMCs were significantly lower in the Mooren's ulcer group than those in the normal control group (Z =-3.47,-3.06,both at P=0.00) ;While the relative expression of Stat5 mRNA in PBMCs was insignificant changed between the two groups (Z =-1.05,P =0.33).Conclusions Th1 and Th2 cells are unbalanced in the active Mooren's ulcer patients.In addition,the down-expression of relevant transcription factors in peripheral blood also is seen in these patients.It is inferred that Th1 and Th2 cells may participate in the progress of Mooren's ulcer.
    • 刘明娜; 孙秀丽; 史伟云
    • 摘要: 目的分析探讨全身应用免疫抑制剂联合手术治疗合并坏死性巩膜炎的难治性蚕蚀性角膜溃疡的疗效。方法回顾性系列病例研究。山东省眼科医院2004年1月至2011年7月诊治的伴有坏死性巩膜炎的严重蚕蚀性角膜溃疡者7例(7眼)。治疗原则:①药物治疗:口服环孢素胶囊和强的松片,根据病情减量维持半年,无复发时停用。局部应用1%环孢素滴眼液和妥布霉素地塞米松滴眼液,4次/d,逐渐减量维持。②手术治疗:巩膜坏死范围〈1/4象限者,行巩膜修补术;角膜溃疡范围≤全角膜1/2者,行部分板层角膜移植术:角膜溃疡范围〉全角膜1/2者或巩膜坏死范围〉1/2象限者均行结膜瓣遮盖术。术后3个月内每半个月复查1次,之后每个月复查1次至术后1年,1年后每2个月复查1次。结果7例中有3例行结膜瓣遮盖术,4例行部分板层角膜移植术联合巩膜修补术。行结膜瓣遮盖术的3例患者术后结膜瓣血运好,溃疡愈合,眼表稳定,随访期间未见原发病复发。行部分板层角膜移植术联合巩膜修补术的4例,随访期间3例未见原发病复发,1例因自行停药1.5个月,巩膜自溶再次人院,给予巩膜修补术联合药物治疗,随访2年未见复发。随访期内7例患者未见角膜移植术后免疫排斥反应的发生,未见因药物副作用所致停药。结论全身应用免疫抑制剂联合手术治疗伴有坏死性巩膜炎的难治性蚕蚀性角膜溃疡有效,全身和局部联合应用免疫抑制剂可以明显提高手术成功率。
    • 刘明娜; 孙秀丽; 史伟云
    • 摘要: 目的 分析探讨全身应用免疫抑制剂联合手术治疗合并坏死性巩膜炎的难治性蚕蚀性角膜溃疡的疗效.方法 回顾性系列病例研究.山东省眼科医院2004年1月至2011年7月诊治的伴有坏死性巩膜炎的严重蚕蚀性角膜溃疡者7例(7眼).治疗原则:①药物治疗:口服环孢素胶囊和强的松片,根据病情减量维持半年,无复发时停用.局部应用1%环孢素滴眼液和妥布霉素地塞米松滴眼液,4次/d,逐渐减量维持.②手术治疗:巩膜坏死范围<1/4象限者,行巩膜修补术;角膜溃疡范围≤全角膜1/2者,行部分板层角膜移植术;角膜溃疡范围>全角膜1/2者或巩膜坏死范围>1/2象限者均行结膜瓣遮盖术.术后3个月内每半个月复查1次,之后每个月复查1次至术后1年,1年后每2个月复查1次.结果 7例中有3例行结膜瓣遮盖术,4例行部分板层角膜移植术联合巩膜修补术.行结膜瓣遮盖术的3例患者术后结膜瓣血运好,溃疡愈合,眼表稳定,随访期间未见原发病复发.行部分板层角膜移植术联合巩膜修补术的4例,随访期间3例未见原发病复发,1例因自行停药1.5个月,巩膜自溶再次入院,给予巩膜修补术联合药物治疗,随访2年未见复发.随访期内7例患者未见角膜移植术后免疫排斥反应的发生,未见因药物副作用所致停药.结论 全身应用免疫抑制剂联合手术治疗伴有坏死性巩膜炎的难治性蚕蚀性角膜溃疡有效,全身和局部联合应用免疫抑制剂可以明显提高手术成功率.%Objective To evaluate the efficacy of using immunosuppressive agents and surgery for refractory Mooren's ulcer combined with necroscleritis.Methods In a retrospective study,7 patients who were diagnosed with refractory Mooren's ulcer combined with necroscleritis between January 2004 and July 2011 at Shandong Eye Hospital were included.The treatment for the patients was determined by the following principles:first,oral cyclosporin A and prednisone were administered for half a year based on the condition,glucocoreicoid eye drops and cyclosporin A eye drops were used four times daily and reduced according to the condition; second,when the corneal ulcer area was smaller than half the area of the cornea,lamellar keratoplasty was performed; and when the area of the scleral necrosis was less than 1/4 quadrant,scleral neoplasty was performed; the remaining patients underwent conjunctival flap surgery.Patients were followed up twice a month for 3 months,once a month for 1 year and every two months thereafter.Results Three eyes were treated with conjunctival flap,and these 3 eyes recovered ocular surface stabilization.No recurrence was observed in these 3 patients during the follow-up period.The other 4 eyes were treated by lamellar keratoplasty combined with scleral neoplasty.In these patients,recurrence was discovered in 1 patient who had stopped using the systemic drugs.Scleral neoplasty was performed again on this patient,and postoperative medications were continued.No recurrence was observed.No significant complications related to drug use were observed in any patient during the study period.Conclusion The treatment of immunosuppresive agents and surgery are effective in patients with refractory Mooren's ulcer combined with necroscleritis.Using systemic and partial immunosuppresive agents can effectively decrease the incidence of recurrence.
    • 黎明; 姚晓明; 彭云; 林宝涛; 曾爱能
    • 摘要: Objective To study the occult perforation in Mooren's ulcer by anterior segment OCT,and provide the basis for clinical diagnosis and treatment.Methods Defined the inner lesions of Mooren's ulcer as the occult perforation by anterior segment OCT,and measured the perforated inner diameter.Results The occult perforation rate of Mooren's ulcer were 8.3%,the minimum inner diameter of occult perforation was 1.8mm,the maximum inner diameter of that was 4.5mm,average of that was 3.1 ± 0.97mm.Conclusions It's helping to identify occult perforation of Mooren' s ulcer by anterior segment OCT,and has an important role for the assessment of the patient's prognosis and surgery program design.%目的 采用眼前节全景OCT研究蚕蚀性角膜溃疡发生隐匿性穿孔的情况,为临床诊治提供依据.方法 采用眼前段全景OCT观察蚕蚀性角膜溃疡,发现溃疡灶内口角膜组织缺损则定为隐匿性穿孔,并测量穿孔内径.结果 眼前节全景OCT发现蚕蚀性角膜溃疡隐匿性穿孔的发生率为8.3%,穿孔内口直径最小为1.8 mm,最大为4.5 mm,平均为(3.1±0.97) mm.结论 对蚕蚀性角膜溃疡患者进行眼前节全景OCT检查,有助于发现隐匿性穿孔的情况,对于评估患者的预后及手术方案的设计有重要作用.
    • 黄平; 王达
    • 摘要: 目的:探讨结膜后退加角膜缘血管冷冻治疗蚕蚀性角膜溃疡的临床疗效.方法:回顾性分析15例16眼蚕蚀性角膜溃疡的治疗情况.结果:13例14眼治愈,2例2眼好转.结论:结膜后退加角膜缘血管冷冻是治疗蚕蚀性角膜溃疡的有效方法.
    • 王秀先; 史伟云; 李素霞; 王婷; 高华
    • 摘要: 目的观察部分环状板层角膜移植治疗早期药物治疗无效的进展性蚕蚀性角膜溃疡的临床疗效。方法回顾性系列病例研究。10例(11眼)常规给予局部及全身免疫抑制剂和对症治疗1周及以上、病灶不断扩散的蚕蚀性角膜溃疡患者,行部分环状板层角膜移植手术,角膜供体选自部分穿透性角膜移植术后残留的环形供体角膜。手术方法:采用7.75-8.00mm的环钻在角膜中央压痕,在彻底切除病灶后,覆盖与病灶范围相同的供体角膜。随访6-36个月,观察患者的视力、角膜植片愈合时间及是否复发等。采用重复测量方差分析比较手术前后视力变化。结果患者裸眼视力术后1个月平均提高(1.36±1.21)行,术后3个月平均提高(1.72±1.47)行,术后6个月平均提高(1.86±2.04)行:最佳矫正视力术后1个月平均提高(0.46±0.93)行,术后3个月平均提高(0.73±1.10)行,术后6个月平均提高(1.55±1.75)行。手术前后裸眼视力(F=5.630,P〈0.05)与最佳矫正视力忙5.925,P〈0.05)差异均有统计学意义。术后患者角膜植片上皮平均愈合时间为(7.00±5.31)d;1例患者术后角膜植片上皮愈合不良,行羊膜移植术后20d愈合;1例患者术后19个月复发,行二次部分板层角膜移植。所有患者随访期间未发生免疫排斥反应等并发症。结论使用环形供体角膜的部分板层角膜移植能有效控制早期药物治疗无效的蚕蚀性角膜溃疡的发展,保存视轴区透明角膜,术后视觉效果良好,同时节约角膜供体材料。
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