摘要：
Objective Uranium, as a heavy metal material, has been used in civil and military activities in China, but it has also caused environmental pollution and human injury.In order to understand and mitigate this injury, scholars studied the damage effect of uranium through building animal models, and found that when uranium enters the animal body, it will accumulate in the body and cause damage to the body, among which the main accumulation organs are kidneys, bones, reproductive organs and so on.Sensitive organs of the role of reproductive organs is uranium, which attracted the attention of the experts, and expand the uranium exposed reproductive toxicity research.They found that the degree of toxicity of uranium is related to the time, dose and mode of uranium exposure, under certain exposure conditions, by changing the sex hormone levels in vivo, the expression of genes or proteins related to the reproductive disorders and excessive produce the mechanism, such as oxidative stress on the toxicity effect, decrease of childbirth pregnant, related to germ cell pathological histology change, and produce genetic reproductive toxicity to the offspring etc., which affect the reproductive system function, damage the health of the body.%目的 铀作为一种重金属材料,虽然在民事和军事活动中得到应用,但同时也造成了环境污染和人员伤害.为了解以及减轻这种伤害,学者们通过构建动物模型,对其损伤效应进行了研究,发现铀进入动物体内后,会在体内蓄积,进而对机体产生损伤,其中主要的蓄积器官是肾、骨骼和生殖器官等.生殖器官作为铀作用的敏感器官,引起了专家们的注意,并对铀暴露的生殖毒性展开了研究,发现铀毒性作用的程度与铀暴露时间、剂量和方式有关,在一定暴露条件下,可通过改变体内性激素水平、紊乱生殖有关的基因或蛋白表达和过度产生氧化应激等机制,对机体产生毒性效应,使亲代的怀孕分娩率下降、相关生殖细胞发生病理组织学改变和对子代产生遗传生殖毒性等,进而影响其生殖系统功能,损害机体的健康.
